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Myocardial infarction (MI) leads to irreversible ischemic damage of the heart muscle and is the leading cause of heart failure. The ischemic cardiac injury triggers a potent local and systemic immune response. In the acute phase post-MI, neutrophils infiltrate the myocardium in large numbers and induce further cardiomyocyte death, expanding the infarcted area. The alarmin S100A8/A9 is a proinflamm

The first measurements of elliptic flow of π ±, K ±, p + p ¯ , KS0 , Λ + Λ ¯ , ϕ, Ξ −+ Ξ ¯ + , and Ω −+ Ω ¯ + using multiparticle cumulants in Pb–Pb collisions at sNN = 5.02 TeV are resented. Results obtained with two- (v 2{2}) and four-particle cumulants (v 2{4}) are shown as a function of transverse momentum, p T, for various collision centrality intervals. Combining the data for both v 2{2} an

The addition of metal intercalants into the van der Waals gaps of transition metal dichalcogenides has shown great promise as a method for controlling their functional properties. For example, chiral helimagnetic states, current-induced magnetization switching, and a giant valley-Zeeman effect have all been demonstrated, generating significant renewed interest in this materials family. Here, we pr

Acoustic streaming shows great potential in applications such as bubble dynamics, cell aggregation, and nanosized particle isolation in the biomedical and drug industries. As the acoustic shock distance decreases with the increase of incident frequency, the nonlinear propagation effect will play a role in acoustic streaming, e.g., Eckart (bulk) streaming at a few gigahertz. However, the theory of

Escape from cytotoxic T lymphocyte (CTL) responses toward HIV-1 Gag and Nef has been associated with reduced control of HIV-1 replication in adults. However, less is known about CTL-driven immune selection in infants as longitudinal studies of infants are limited. Here, 1,210 gag and 1,264 nef sequences longitudinally collected within 15 months after birth from 14 HIV-1 perinatally infected infant

It is increasingly important to rapidly receive information on the antimicrobial susceptibility of bacteria due to the rise in antimicrobial resistance worldwide. However, traditional phenotypic methods are time-consuming. Thus, the objective of this study was to develop a rapid assay that can detect antibiotic-resistant bacterial isolates phenotypically in less than 2 h. The microplate assay used

Introduction: This article contributes to the discussion on digital transformation and welfare technology in municipal eldercare. The aim of welfare technology solutions is to exceed the current welfare system and to meet the challenges of an ageing population through technological innovations and applications that help people to better cope with health issues and strengthen their participation, a

Local genetic correlation analysis is an important tool for identifying genetic loci with shared biology across traits. Recently, Border et al. have shown that the results of these analyses are confounded by cross-trait assortative mating (xAM), leading to many false-positive findings. Here, we describe LAVA-Knock, a local genetic correlation method that builds off an existing genetic correlation

Antimicrobial resistance (AMR) is a fast-growing threat to global health. The genes conferring AMR to bacteria are often located on plasmids, circular extrachromosomal DNA molecules that can be transferred between bacterial strains and species. Therefore, effective methods to characterize bacterial plasmids and detect the presence of resistance genes can assist in managing AMR, for example, during

Tumor growth rate estimations can provide useful information about tumor progression and aggressiveness. Understanding the breast cancer progression and aggressiveness could aid with personalized screening/follow-up, treatment options, and prognosis. This paper reports a preliminary estimation of the tumor volume doubling time (TVDT) for cancers detected during the Malmö Breast Tomosynthesis Scree

Software reliability is an important characteristic for most systems, but due to its dynamic properties it is hard to assess until very late in the development. Nevertheless, the testing must be planned to meet the reliability requirements. In test planning, the notion of usage coverage may be used as an indicator of reliability as they are correlated with each other. When the testing is planned,