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Adverse conditions in childhood manifest in a risk for long-term illness and poor labour market performance in the future and add to future health problems. Children and young people in need of care are particularly vulnerable as their future depends on their parents and family and the legal system as well as on social welfare. By identifying their needs we can develop new and relevant knowledge a

Amyloid fibril formation is a hallmark of neurodegenerative disease caused by protein aggregation. Oligomeric protein states that arise during the process of fibril formation often coexist with mature fibrils and are known to cause cell death in disease model systems. Progress in this field depends critically on development of analytical methods that can provide information about the mechanisms an

The European Union (EU) annually publishes an Innovation Union Scoreboard (IUS) as a tool to measure the innovation performance of EU Member States by means of a composite index, called the Summary Innovation Index (SII). The SII is constituted by an average of 25 indicators. The SII is claimed to rank Member States according to their innovation performance. This means that the higher the average

This report presents the results of a set of verification and validation tests of a probabilistic risk assessment tool, named ARTU (Italian acronym for Risk Analysis in Tunnels), for road tunnel fire safety. This is performed along with a literature review to identify key factors that affect the tunnel fire risk along with inputs for the risk assessment tool. To perform the validation of the 1D fl

Objectives: Assess the relationship of cognitive impairment to disability, accounting for depression severity and frailty, among older adults with late-life depression (LLD). Methods: Data were analyzed from 78 community-dwelling older adults with LLD and without dementia (age M = 71.9; SD = 6.1). Cognitive functioning was assessed using a comprehensive neuropsychological battery. Depression sever

Methylation of biomolecules is a frequent biochemical reaction within the cell, and a plethora of highly specific methyltransferases (MTases) catalyse the transfer of a methyl group from S-adenosylmethionine (AdoMet) to various substrates. The posttranslational methylation of lysine residues, catalysed by numerous lysine (K)-specific protein MTases (KMTs), is a very common and important protein mo

This study investigated the effect of biogenic AgNPs on seed germination and seedling growth of Solanum lycopersicum. Treatment with silver nanoparticles (AgNPs) showed a significantly high germination rate and seedling growth compared to untreated seeds. Furthermore, its bactericidal effect against bacterial pathogen Clavibacter michiganensis subsp. michiganensis (cmm) infection in Solanum lycope

Rationale: Cerebrovascular diseases associated with pregnancy and postpartum period are uncommon; however, they can have an important impact on health of both women and foetus or newborn. Aims: To evaluate the frequency, characteristics and management of cerebrovascular events in pregnant/postpartum women, to clarify pathophysiological mechanisms underlying the occurrence of these events including

Astrocytes support normal brain function, but may also contribute to neurodegeneration when they become reactive under pathological conditions such as stroke. However, the molecular underpinnings of this context‐dependent interplay between beneficial and detrimental properties in reactive astrogliosis have remained incompletely understood. Therefore, using the RiboTag technique, we immunopurified

Background: Ketogenic diet in children with epilepsy has a considerable impact on daily life and is usually adopted for at least 3 months. Our aim was to evaluate whether the introduction of an all-liquid ketogenic diet in an outpatient setting is feasible, and if an earlier assessment of its efficacy can be achieved.Methods: The authors conducted a prospective, observational study in a consecutiv

Increased oxidative stress is implicated in the pathogenesis of Alzheimer's disease (AD). A large body of evidence suggests that mitochondrial dysfunction and increased reactive oxygen species occur prior to amyloid-β (Aβ) deposition. Coenzyme Q10 (CoQ10), a component of the mitochondrial electron transport chain, is well characterized as a neuroprotective antioxidant in animal models and human tr

Background: Today, patient self-determination has become an issue in many western countries due to the widespread availability and use of technology, which makes it possible to prolong life often in spite of severe disability and poor quality of life. Many people fear an overzealous use of modern life-saying procedures which merely serve to prolong the dying process. As a first step towards autono

In this work, the new ANO-R basis set for all elements of the first six periods is introduced. The ANO-R basis set is an all-electron basis set that was constructed including scalar-relativistic effects of the exact-two component (X2C) Hamiltonian and modeling the atomic nucleus by a Gaussian charge distribution, which makes the basis set suitable for calculations of both light and heavy elements.

Most migrating birds need to stopover in between flights in order to refuel. Lately, additional purposes of stopover have been suggested, including physiological recovery from metabolically demanding migratory flight. One apparently unavoidable, but harmful physiological effect of migratory flight is increased oxidative damage to lipids and proteins. We here, for the first time, tested whether mig

BACKGROUND: The aim of this study was to investigate the effects of a web-based treatment program with therapist guidance for adults and adolescents with regular cannabis use from the general population. METHODS: A double blinded randomized controlled trial with a parallel group design was conducted (intervention group n = 151, wait-list control group n = 152). Follow-up 12 weeks from treatment co

Stable HCCI combustion requires a proper level of fuel reactivity. This study shows that adding ethanol as a renewable fraction to low octane gasoline decreases the reactivity of the gasoline, while adding 2-ethyl hexyl nitrate (2-EHN) can enhance the reactivity of the blend and counter the effect of ethanol.The experimental apparatus consisted of a modified CFR engine for HCCI combustion equipped