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On the mechanisms that limit oxygen uptake during exercise in acute and chronic hypoxia: role of muscle mass

Peak aerobic power in humans ((V) over dot(O2), peak) is markedly affected by inspired O-2 tension (F-IO2). The question to be answered in this study is what factor plays a major role in the limitation of muscle peak. (V) over dot(O2) in hypoxia: arterial O-2 partial pressure (P-a,(O2)) or O-2 content (C-a,C-O2)? Thus, cardiac output (dye dilution with Cardio-green), leg blood flow (thermodilution

Alpha-1-microglobulin, heme-binding protein, reductase and antioxidant

Popular Abstract in Swedish Alla levande organismer består av celler som tillsammans med molekyler generellt kallade extracellulär matrix bildar en vävnad. Celler innehåller fyra huvudgrupper av byggstenar: socker, fettsyror, aminosyror och nukleotider, vilka i tur och ordning bildar kolhydrater, fetter, proteiner och nukleinsyror. I vävnaderna pågår en ständig omsättning av byggstenarna och molek

Achievment of sustainable solid waste management in developing countries

With an increasingly population and urbanization, the solid waste management have become a major challenge for local authorities in developing countries all over the world. The local authorities must improve their waste management in order to minimize the negative effects of solid waste and to avoid future land use conflicts. At the same time the economical resources are limited and solid waste ma

Advanced decision support methods for solving diffuse water pollution problems

Dealing with water diffuse pollution is a major problem for watershed managers. This problem raises many complicated questions, which are important to answer in order to reach water environment protection goals. This study suggested some possible answers for the country of Lithuania. Among them were the identification of critical source areas, the identification of sensitive areas and the applicat

Gemensam bostad ur ett företagsperspektiv

De flesta makar och sambor bor tillsammans i en fastighet eller i en lägenhet som de vanligtvis betraktar som deras gemensamma bostad. Inte ovanligt är att fastigheten utgör en lantbruksfastighet eller att någon av parterna bedriver näringsverksamhet i bostaden. För makar och sambor finns i äktenskapsbalken respektive sambolagen ett par skydds¬regler som kan bli tillämpliga vid en separation mellaThe majority of married couples and co-habitants live together in rented or owned accommodation which they usually consider to be their joint property. It is not unusual that the property is an agricultural property or that one half of the couple use the property for business purposes. There are protective provisions in The Marriage Code and also in The Cohabitees Act which are relevant in case of

Comparative heat stress study of acorn barnacles Tetraclita japonica and Tetraclita squamosa of Cape D’aguilar, Hong Kong

Abstract: The physiological responses of two Hong Kong acorn barnacles, Tetraclita japonica and T. squamosa differed under identical heat stress conditions. Both species experienced increased body temperature and mantle water osmolality with higher temperatures and prolonged emersion time. Species comparisons however, showed that T. japonica had warmer body temperatures and more concentrated osm

Nairobi city journey planner : an online and a mobile application

Popular science: Public transport plays an important role in enabling people to move from one place to another. The provision of information related to public transportation enables travelers to pre-plan their journeys and even save time that would have been spent asking around or looking for this information from other sources. The city of Nairobi has a population of about four million people, mo

Feasibility of an evidence-based educational intervention in screening immigrant mothers for postpartum depression : A pretest-posttest experimental design

BACKGROUND: Screening immigrant mothers for postpartum depression has been shown to be challenging for health care professionals in handling cultural implications of postpartum depression, communicating through interpreter and applying translated versions of the screening scale.AIM: The aim of the study was to test the feasibility of an evidence-based educational intervention for Child Health Serv

Early Ezetimibe Initiation After Myocardial Infarction Protects Against Later Cardiovascular Outcomes in the SWEDEHEART Registry

Background: Combination lipid-lowering therapy (LLT) after myocardial infarction (MI) achieves lower low-density lipoprotein cholesterol (LDL-C) levels and better cardiovascular outcomes vs statin monotherapy. As a result, global guidelines recommend lower LDL-C but, paradoxically, advise treatment through a stepwise approach. Yet the need for combination therapy is inevitable as <20% of patients

Björnkram eller björntjänst? Möjligheter för personer med neuropsykiatriska funktionshinder att känna och uttrycka inflytande i insatser med avsikt att bidra till deras delaktighet i samhället.

In Sweden there are laws and recommendations from The National Board of Health and Welfare about the importance of a user's involvement in and possibility of influencing services directed at them. Even with such good intentions the same board reports that it is hard to know if people experience that they do. The purpose of my study was to examine how professionals can use their knowledge to he

Surgical outcomes of gallbladder cancer: the OMEGA retrospective, multicentre, international cohort study

Background: Gallbladder cancer (GBC) is rare but aggressive. The extent of surgical intervention for different GBC stages is non-uniform, ranging from cholecystectomy alone to extended resections including major hepatectomy, resection of adjacent organs and routine extrahepatic bile duct resection (EBDR). Robust evidence here is lacking, however, and survival benefit poorly defined. This study ass

Deregulation and editing of microRNAs in metastatic prostate cancer

Prostate cancer bone metastasis is still not fully understood, and increased knowledge could aid in the development of better treatment options for patients in the future. This thesis focuses on microRNAs (miRNAs), which modulate gene expression in healthy and tumour cells. Using cell culture, animal and patient studies, we investigated the biological role of microRNA-96 (miR-96) and microRNA-379

Prevalence, Disease-free, and Overall Survival of Contemporary Patients With Renal Cell Carcinoma Eligible for Adjuvant Checkpoint Inhibitor Trials

Introduction: Designing adjuvant trials is challenging because of uncertainties of prevalence and outcome of high-risk renal cell cancer (RCC) despite use of validated risk scores. Our objective is to investigate how differences in eligibility criteria may impact on potential study results in RCC adjuvant trials. Patients and Methods: RECUR is a multicenter European database capturing patient and

Intracavitary Electron FLASH Radiotherapy in a Canine Cancer Patient With Oral Malignant Melanoma

PURPOSE/OBJECTIVE(S): Studies of electron FLASH radiotherapy (FLASH-RT) in companion animals are being conducted at several institutions. High energy electron beams are generally suitable for treatment of superficial cancers, but of limited use for deep-seated tumors. In this case report, the feasibility of intracavitary electron FLASH-RT is demonstrated.MATERIALS/METHODS: A canine cancer patient

On norovirus outbreaks and transmission in hospitals

Abstract Noroviruses are now the leading cause of gastroenteritis worldwide. Noroviruses are effectively transmitted due to a low infectious dose, viral shedding in high concentrations, environmental stability, and they induce only a limited immunity after infection. Especially, the norovirus variants of genotype II.4 (GII.4) have seemed greatly adapted for pandemic spread. The high infectivity of

Empowerment and enablement and their associations with change in health-related quality of life after a supported osteoarthritis self-management programme - a prospective observational study

BACKGROUND: Osteoarthritis is a leading cause of disability worldwide. Current treatment supports coping strategies to improve health-related quality of life (HRQoL). The need to predict response to treatment has been raised to personalise care. This study aims to examine change in HRQoL from baseline to three and nine months follow-up after participating in a Supported Osteoarthritis Self-Managem

Neuropsychological outcome after cardiac arrest : results from a sub-study of the targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (TTM2) trial

Background: Cognitive impairment is common following out-of-hospital cardiac arrest (OHCA), but the nature of the impairment is poorly understood. Our objective was to describe cognitive impairment in OHCA survivors, with the hypothesis that OHCA survivors would perform significantly worse on neuropsychological tests of cognition than controls with acute myocardial infarction (MI). Another aim was

Retained Metabolic Flexibility of the Failing Human Heart

Background: The failing heart is traditionally described as metabolically inflexible and oxygen starved, causing energetic deficit and contractile dysfunction. Current metabolic modulator therapies aim to increase glucose oxidation to increase oxygen efficiency of adenosine triphosphate production, with mixed results. Methods: To investigate metabolic flexibility and oxygen delivery in the failing

A preanalytic validation study of automated bone scan index : Effect on accuracy and reproducibility due to the procedural variabilities in bone scan image acquisition

The effect of the procedural variability in image acquisition on the quantitative assessment of bone scan is unknown. Here, we have developed and performed preanalytical studies to assess the impact of the variability in scanning speed and in vendor-specific γ-camera on reproducibility and accuracy of the automated bone scan index (BSI). Methods: Two separate preanalytical studies were performed: