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Background In ST-elevation myocardial infarction (STEMI), distal embolization of thrombus material often precludes restoration of normal coronary artery flow. Small-scaled studies have demonstrated that intracoronary thrombus aspiration improves flow and myocardial perfusion, but only one larger randomized single-center study has suggested a survival benefit. Thrombus aspiration is widely used in
Weak alignment of requirements engineering (RE) with verification and validation (VV) may lead to problems in delivering the required products in time with the right quality. For example, weak communication of requirements changes to testers may result in lack of verification of new requirements and incorrect verification of old invalid requirements, leading to software quality problems, wasted ef
No consensus treatment regime exists beyond surgery for malignant peripheral nerve sheath tumours (MPNST), and the purpose of the present study was to find new approaches to stratify patients with good and poor prognosis and to better guide therapeutic intervention for this aggressive soft tissue cancer. From a total of 67 MPNSTs from Scandinavian patients with and without neurofibromatosis type 1
A new technology has emerged the last decade, based on a new group of materials; Soft Magnetic Composites (SMC), instead of laminated steel that facilitates production of products with more integrated, smaller, lighter, less costly and highly efficient electromagnetic machines. The application of this technology is a change of paradigm regarding integrated design and energy efficiency. This articl
Type 1 diabetes (T1D) is an autoimmune disease associated with the destruction of pancreatic β cells and genetically linked to human leukocyte antigen (HLA) class II DR3-DQ2 and DR4-DQ8 haplotypes. The +49A/G polymorphism of the immunoregulatory cytotoxic T-lymphocyte antigen 4 (CTLA-4) gene is also associated with T1D. Genetic and environmental risk factors precede the onset of T1D, which is char
Various studies have highlighted older persons' problems in potentially failing to keep pace with developments in information technology and the latest technologies that prevent physical and social loss. In contrast to such studies that treat users as static and technology as changing, it's important to understand the use of technology can change over time. For example, older persons have used tec
Purpose. When performing perimetry, refracting subjects with central visual field loss, and in emmetropization studies, it is important to accurately measure peripheral refractive errors. Traditional methods for foveal refraction often give uncertain results in eccentric angles as a result of the large aberrations and the reduced retinal function. The aim of this study is therefore to compare and
In response to the pressures of predation, parasitism and competition for limited resources, several groups of (mainly) tropical bees and wasps have independently evolved a nocturnal lifestyle. Like their day-active (diurnal) relatives, these insects possess apposition compound eyes, a relatively light-insensitive eye design that is best suited to vision in bright light. Despite this, nocturnal be
OBJECTIVE: To investigate differences in semen quality between samples collected by masturbation at a clinic and at home. DESIGN: Cross-sectional study. SETTING: Fertility center. PATIENT(S): Three hundred seventy-nine men assessed for infertility. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Semen was analyzed according to World Health Organization guidelines. Seminal markers of epididymal (ne
Background: In recent years an increase of the incidence of nosocomial outbreaks caused by noroviruses has been observed throughout Sweden, with high peaks noted in the winter seasons 2002/2003 and 2004/2005, respectively. Objectives: To phylogenetically characterize norovirus strains causing nosocomial outbreaks from 1997 to 2005 and estimate the impact of norovirus-like disease on the Swedish he
Accumulating evidence suggests that AIDS orphanhood status is accompanied by increased levels of psychological distress such as anxiety, depression, intense guilt, shame, and anger. However, few studies have examined the possible reduction of psychological distress in AIDS orphans through the help of interventions that promote well-being. The objective of the study was to evaluate the effects of a
Objective: Fasting insulin concentrations are often used as a surrogate measure or insulin resistance. We investigated the relative contributions Of fasting insulin and insulin resistance to cardiometabolic risk and preclinical atherosclerosis. Design and methods: The Relationship between Insulin Sensitivity and Cardiovascular disease (RISC) cohort consists of 1326 European non-diabetic. overall h
OBJECTIVE: : To report the effects of glucocorticoid treatment of acute vestibular neuronitis on recovery of vestibular function and length of hospital stay. STUDY DESIGN: : Prospective, consecutive case series compared with historic controls. SETTING: : Secondary referral academic hospital. PATIENTS: : Patients with acute vestibular neuronitis. One group treated with glucocorticoids within 3 d
Calcitonin gene-related peptide (CGRP) and nitric oxide (NO) are two molecules shown to have a role in migraine pathophysiology. Our objective was to test the hypothesis that migraine subjects are particularly sensitive to these signal molecules. The cutaneous microvascular responses to endothelial and non-endothelial dependent dilators were tested using laser Doppler flowmetry in combination with
The design of an in vitro immunization system based on a synthetic heterotope immunogen, which was a peptide containing both T- and B-cell epitopes, that elicited a neutralizing, primary human humoral immune response against the human immunodeficiency virus (HIV-1) is reported here. This heterotope construct contained the major neutralizing B-cell epitope, within the V3 region of glycoprotein 120
Sown flower strips are increasingly implemented within agri-environment schemes (AES) to increase functional biodiversity and ecosystem services such as pollination or natural pest control, but their effectiveness in achieving these goals remains poorly studied. We tested the performance of experimentally sown annual flower strips specifically designed to promote natural enemies of aphids a
Future connected vehicles will require high-performance communication technologies for advanced cooperative driving applications such as maneuvering and cooperative perception. mmWave communications can meet the bandwidth requirements of such applications, but the typically harsh propagation conditions of vehicular environments hinder the broad adoption of mmWave devices on cars. Reconfigurable in
