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Purpose: Previous studies have shown that at a similar body mass index, Middle Eastern immigrants are more insulin resistant and at higher risk for type 2 diabetes (T2D) than native Europeans. Insulin resistance is strongly associated with disturbed fat metabolism and cardiovascular disease (CVD). However, fat metabolism is poorly investigated comparing Middle Eastern and European ethnicities. Met
OBJECTIVE: To compare experts' perceived usefulness of audit filters from Ghana, Cameroon, WHO and those locally developed; generate context-appropriate audit filters for trauma care in selected hospitals in urban India; and explore characteristics of audit filters that correlate to perceived usefulness.DESIGN: A mixed-methods approach using a multicentre online Delphi technique.SETTING: Two large
Hybridization can result in novel allelic combinations which can impact the hybrid phenotype through changes in gene expression. While misexpression in F1 hybrids is well documented, how gene expression evolves in stabilized hybrid taxa remains an open question. As gene expression evolves in a stabilizing manner, break-up of co-evolved cis- and trans-regulatory elements could lead to transgressive
BACKGROUND: Twin studies have been criticized for upwardly biased estimates that might contribute to the missing heritability problem.METHOD: We identified, from the general Swedish population born 1960-1990, informative sibships containing a proband, one reared-together full- or half-sibling and a full-, step- or half-sibling with varying degrees of childhood cohabitation with the proband. Estima
Popular Abstract in English Alcohols and aldehydes are used in the chemical industry largely as a starting material for the manufacture of a wide range of products. They are also used as such in various industrial applications. The flexibility is due mainly to the functionalities of the alcohols and aldehydes being hydroxylic and carbonylic, respectively. Much interest is directed nowadays at convNowadays, transition metal oxide catalysts are employed to a large extent in many chemical processes for the selective production of chemicals and intermediates. Although metal oxides are mostly known as oxidation catalysts, they can successfully catalyze a wide range of reactions, such as dehydration. Two different processes have been studied in the present work: the selective oxidation of methan
DNA is presently at the centre of a storm. On the one hand, the breathtaking development of DNA related sciences during the last decades led to a technological and medical revolution. Due to the far reaching possibilities connected to this technology, it is the focus of many people’s interest and one source of the hope that one day we will find cures for terrible illnesses. Unsurprisingly, DNA re
The influential scholar Ulrich Luz rejects the view of the Gospel of Matthew as an ancient biography, since he does not find any information about the education or the development of Jesus in the narrative from chapter 3. This conclusion does not give a fair description of neither ancient biographies in general nor the Gospel of Matthew in particular. Matthew actually picks up important themes in
High-grade serous ovarian cancer (HGSOC) is the most lethal subtype of ovarian cancer and remains a major clinical challenge due to frequent late diagnosis and limited treatment options. This study investigates the therapeutic potential of targeting the oncogenic interaction between metadherin (MTDH) and staphylococcal nuclease domain-containing 1 (SND1) which are proteins known to promote tumor p
High grade serous ovarian cancer (HGSOC) is accompanied by an immune-rich but heterogenous tumor microenvironment. Although tumor associated tertiary lymphoid structures (TLS) are linked to favourable antitumor immunity, B cells may also adopt spatial distribution patterns favourable for immune suppression. This study evaluated whether the abundance and spatial distribution patterns of CD20+ B cel
BackgroundPreliminary results from the SNAP trial presented at ESCMID Global 2025 reported a high incidence (19.8%) of acute kidney injury (AKI) in patients treated with (flu)cloxacillin for Staphylococcus aureus bacteraemia (SAB).ObjectiveIn Sweden, cloxacillin is used at lower daily doses, and the risk of nephrotoxicity has not been assessed in this setting.MethodsWe retrospectively evaluated re
Background: The Peritoneal Cancer Index recorded at laparotomy is based on visual and palpable inspection of peritoneal surfaces for disease. This study aimed to analyze interobserver variation in assigning the lesion score (LS) and morphologic term (MT) to characterize peritoneal lesions (PL) and predict the probability of malignancy (POM) among surgeons with expertise in cytoreductive surgery (C
Background The aim of this systematic review and meta-analysis was to examine autoantibody positive individuals and define: (a) the relative risk of rheumatoid arthritis (RA) compared with autoantibody negative individuals and (b) the cumulative incidence of RA over time, in different populations. Methods A systematic literature search was performed in August 2025. Retrospective case control studi
Background Multimorbidity, the co-occurrence of two or more non-communicable diseases (NCDs), is common and has been linked to venous thromboembolism (VTE). Whether multimorbidity diagnosed in primary-care is associated with incident VTE remains unclear. We aimed to examine this association. Methods Multimorbidity was defined using Swedish primary-care data. Individuals without prior VTE were incl
Purpose: This paper aims to explore Swedish municipalities’ adoption of politically decided goals and targets, within the budget document, that are formulated for the accounting unit of the municipal group. Design/methodology/approach: A regression analysis of the adoption of financial and non-financial performance measurement by 289 Swedish municipalities was performed, including eight independen
Permanent ponds are key landscape units that supply various ecosystem services. Notably, the export of aquatic subsidies to land via emerging insects may significantly influence terrestrial food webs. Polyunsaturated fatty acids (PUFA), which enhance consumer fitness, are among the essential exported components. The patterns and drivers of dietary exports from ponds via insects remain poorly known
Study region: The Brazilian wooded Cerrado biome is a tropical savanna, over 50 % of which has been converted to agricultural land. Study focus: We evaluated changes in water balance variables (surface flux, evaporation, soil-water storage, infiltration, groundwater recharge, and root uptake) due to climate change. The study included (i) calibration and validation of the Hydrus model through obser
In order to elucidate the multidimensional response mechanism for migration of antibiotics and spread of resistome in riverbed driven by river water level fluctuations, dynamic reactors were set up to simulate the variation of sulfamethazine vertical migration, biotransformation and resistance genes expression according to fluctuation direction and magnitude. The upward fluctuation of water level
