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With the development of ultrafast laser technology, time-resolved spectroscopy has become an essential tool to study the microscopic photophysical mechanisms on ultrafast time scales in the field of solar energy conversion and utilization. Transient absorption spectroscopy (TAS), as an essential technology for studying photoinduced ultrafast electron transfer and photo-induced carrier dynamics, ha
Background. Post-traumatic chondral and osteochondral lesions can be treated with autologous chondrocyte implantation (ACI), but the high cost of autologous cell expansion under strict Good Manufacturing Practice (GMP) regulations limits patient access. Stem cell–based advanced therapy medicinal products (ATMPs) offer more cost-effective alternatives, with human induced pluripotent stem cells (iPS
Polyamines are regulatory metabolites with key roles in transcription, translation, cell signalling and autophagy1. They are implicated in multiple neurological disorders, including stroke, epilepsy and neurodegeneration, and can regulate neuronal excitability through interactions with ion channels2. Polyamines have been linked to pain, showing altered levels in human persistent pain states and mo
Solar-driven hydrogen production stores renewable energy chemically but suffers from efficiency limitations due to the slow hole transport-dominated recombination, which caused by high valence band degeneracy and hole effective mass. Targeted hole trap regulation is essential to minimize these losses and enhance photocatalytic H2 evolution performance for practical applications. This study address
Background: The eco-corona, consisting of environmental biomolecules formed around engineered nanomaterials (ENMs) when released to the environment, has gained increasing focus in the scientific literature and its role for ENM fate and toxicity is now widely acknowledged. The European chemicals legislation, REACH, entails reporting requirements when it comes to the transformation of nanoforms. Gui
Perovskites have attracted widespread attention for laser applications due to their excellent optoelectronic properties. However, perovskite lasers typically exhibit a wavelength shift as pump density increases. Here, we report a pump-induced wavelength shift-free laser achieved using a perovskite nanoplatelet with mixed orthorhombic and tetragonal phase. At 293 K, the tetragonal-phase perovskite
Mononuclear iron(iv)-oxo, iron(iv)-imido and iron(iv)-nitrido complexes are common catalytic cycle intermediates in enzymes, where the metal is typically linked to the protein through cysteinate or histidine sidechains. Enzymatic high-valent iron(iv)-imido and -nitrido intermediates have never been trapped and characterized; hence, there is uncertainty regarding their structure and function. Using
The birth prevalence of cleft lip and/or palate (CL/P) varies globally, and regional differences have previously been observed within Sweden. Updated data on CL/P birth prevalence is needed and has been requested nationally and internationally. This study investigated regional differences and temporal trends in the birth prevalences of CL/P and specific cleft subtypes across Sweden’s six health ca
Near infrared (NIR) fluorescence imaging has received significant attention. However, it remains challenging to develop NIR emitters with a high brightness. Herein, we report a supramolecular approach to formulate NIR fluorescent molecular nanoparticles from cationic NIR fluorophores and cyanostar receptors using their charge-by-charge packing in small-molecule ionic isolation lattices (SMILES). F
Background: Gaming disorder is a recently recognized psychiatric condition and a growing public health concern, particularly among adolescents. Despite this, there is limited research on what kind of treatment they need. Existing studies are mostly quantitative and offer limited insight into adolescents' lived experiences.Aim: The aim of this qualitative study is to explore how adolescent patientsBackground: Gaming disorder is a recently recognized psychiatric condition and a growing public health concern, particularly among adolescents. Despite this, there is limited research on what kind of treatment they need. Existing studies are mostly quantitative and offer limited insight into adolescents’ lived experiences. Aim: The aim of this qualitative study is to explore how adolescent patient
Knee osteoarthritis is a highly prevalent whole-joint disease that is associated with substantial morbidity. If step changes are to be made in the management of knee osteoarthritis, novel patient stratification approaches are needed to identify the most effective treatment for individual patients. Numerous methods for stratifying patients with knee osteoarthritis can be employed; clinical presenta
Biogenic ice-nucleating particles (INPs) can significantly impact mixed-phase clouds by enhancing precipitation and reducing albedo. As Arctic sea ice diminishes, the exposure of open ocean may increase aerosolization rates of marine bioaerosols and INPs. We investigated INP concentrations and microbial communities in ambient marine air, sea bulk water (SBW), and sea surface microlayer (SML) along
BackgroundPatients with advanced ovarian cancer (AOC) who undergo primary and interval debulking surgery are often anemic at diagnosis, with iron deficiency being the most common cause. The aim was to investigate whether preoperative anemia and iron deficiency impact short-term recovery.MethodsThis retrospective cohort study included 262 patients with AOC who underwent surgery at Skane University
The transition to smart, wearable, and flexible optoelectronic devices that communicate with each other and perform neuromorphic computing at the edge, is a major goal in next-generation optoelectronics. These devices are expected to carry out their regular tasks while being supported by energy-efficient, in-memory computations. In this study, a lateral flexible device based on cesium lead tribrom
Epitaxially grown nanowires have shown promise for photovoltaic applications due to their nanophotonic properties. Moreover, the mechanical properties of nanowires can reduce crystallographic defect formation at interfaces to help enable new material combinations for photovoltaics. One material that stands to benefit from the nanowire morphology is zinc phosphide (Zn3P2), which, despite promising
Background: Medial plica is a structure with limited understanding of its pathology, but it may be related to the development of medial knee osteoarthritis (OA). We examined the association between medial plica and medial meniscus extrusion (MME), progression of MME, and the risk of early-stage knee OA development in middle-aged persons. Methods: A total of 340 subjects with tibiofemoral Kellgren–
AimTo understand service users' experiences of their current mental health services and explore reflections on the Flexible Assertive Community Treatment (FACT) model and its role in future practice.MethodsA total of 17 experts participated in individual and dyadic in-depth interviews. A reflexive thematic analysis was performed on the participants' experiences of current mental health services anBackground: A person-centred and recovery-oriented approach is an integral part of modern mental health services founded on the experiential knowledge of service users. Their reflections as experts, grounded in their unique experience as service users, play a significant role in developing and improving the existing care. Experiential knowledge is therefore a means to enhance the relevance of rese
Aims Aortic valve calcification (AVC) is an underlying pathophysiological mechanism for aortic stenosis that is common in the elderly, but less is known in younger individuals. The aim was to study the prevalence and associated characteristics of AVC in a middle-aged general population. Methods and results Data were obtained from the Swedish CArdioPulmonary bioImage Study (SCAPIS) comprising 30 15
Rare earth elements (lanthanides) are critical materials for many applications, particularly those involved in new energy. Extracting these elements economically from low-concentration sources may be challenging. This study investigates the interaction of Ce and Gd with microalgae that have been triggered to form phosphate-rich granules. Lanthanides usually occur in nature as phosphates, and there
When exposed to high levels of phosphate after experiencing phosphate deficiency, microalgae can synthesize granules rich in intracellular phosphate. The understanding of the mechanism of production and nature of these granules remains incomplete. Here we studied phosphate distribution and chemistry in Chlamydomonas reinhardtii and Desmodesmus armatus using scanning transmission X-ray microscopy (
