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Early kidney function decline may be associated with reduced filtration of middle-sized molecules, currently defined as selective glomerular hypofiltration syndrome (SGHS), and driven by the accumulation of atherosclerosis-promoting proteins. We aimed to investigate whether SGHS and other markers of kidney function are associated with subclinical atherosclerosis as evaluated by intima-media thickn
Background: Women who have undergone cervical conization may still experience subsequent pregnancies and delivery. However, it remains unknown whether pregnancy, associated with immune tolerance, might increase the risk of subsequent cervical lesions. This study aims to address this knowledge gap by utilizing the nationwide Swedish registers. Methods: A total of 60,895 women diagnosed with cervica
Background: Low-cost particulate matter sensors have enabled new opportunities for exposure monitoring but require evaluation before application in epidemiological studies. This study assessed the performance of the SPS30 sensor integrated into the ARMIE portable monitoring sensor-node under controlled laboratory conditions. Methods: Sensors were co-located with two comparison instruments—the opti
COSM10 course schedule 2020 Centre for East and South-East Asian Studies COSM10 Asian Studies: Asian Studies, 6 credits Autumn semester 2020, 31 August – 23 September Course schedule Course information The course offers an introduction to critical, interdisciplinary Asian Studies, its historical origin, research history, and some cross-cutting issues in contemporary research. Included are also int
https://www.ace.lu.se/sites/ace.lu.se/files/cosm10_course_schedule_2020.pdf - 2026-05-16
Background: We have previously reported quantitative exposure-response relationships between physical exposures recorded by technical methods, and complaints and diagnoses in the neck/shoulders, and the elbows/hands, based on group data. In the present study the number of workers was doubled, and information on individual factors, and psychosocial working conditions was used. Relationships between
Background Breathlessness is prevalent in the general population and may be associated with adverse health outcomes. This study aimed to evaluate the association of breathlessness with Chronic Obstructive Pulmonary Disease (COPD) events, cardiac events and all-cause mortality from middle-age throughout life. Methods Breathlessness was measured in 699, 55-year old men residing in Malmö, Sweden usin
AIMS: Despite vast clinical experience linking diabetes and atherosclerosis, the molecular mechanisms leading to accelerated vascular damage are still unclear. Here, we investigated the effects of nuclear factor of activated T-cells inhibition on plaque burden in a novel mouse model of type 2 diabetes that better replicates human disease.METHODS & RESULTS: IGF-II/LDLR-/-ApoB100/100mice were ge
Background: Soft-tissue sarcomas (STSs) are a group of rare, heterogeneous, and aggressive tumors, with high metastatic risk and relatively few efficient systemic therapies. We hypothesized that the Genomic Grade Index (GGI), a 108-gene signature previously developed in early-stage breast cancer, might improve the prognostic assessment of patients with early-stage STS. Patients and methods: We col
BACKGROUND: Previous results from Scandinavian cohorts have shown that obesity accentuates the effects of common genetic susceptibility variants on increased triglycerides (TG). Whether such interactions are present in the US population and further selective for particular TG-rich lipoprotein subfractions is unknown. METHODS: We examined these questions using body mass index (BMI) and waist circum
OBJECTIVE Meat intake has been consistently shown to be positively associated with incident type 2 diabetes. Part of that association may be mediated by body iron status, which is influenced by genetic factors. We aimed to test for interactions of genetic and dietary factors influencing body iron status in relation to the risk of incident type 2 diabetes. RESEARCH DESIGN AND METHODS The case-cohor
Background and Aims: The risk of synchronous and metachronous colorectal cancer is influenced by heritable and environmental factors. As a basis for comparative studies, we provide population-based estimates of synchronous and metachronous colorectal cancer with a focus on non-heritable cases. Material and Methods: Based on data from national Danish cancer registers, we estimated the proportion of
Aims: Maintainance of glucagon response to hypoglycaemia is important as a safeguard against hypoglycaemia during glucose-lowering therapy in type 2 diabetes. During recent years, DPP-4 (dipeptidyl peptidase-4) inhibition has become more commonly used in elderly patients. However, whether DPP-4 inhibition affects the glucagon response to hypoglycaemia in the elderly is not known and was the aim of
Background: Abdominal obesity is linked to cardiovascular diseases in type 1 diabetes (T1D). The primary aim was to explore associations between abdominal obesity and cardiovascular complications, metabolic and inflammatory factors. The secondary aim was to explore whether achieved recommended treatment targets differed between the obese and non-obese participants. Methods: Cross sectional study o
Observational studies suggest that higher birth weight (BW) is associated with increased risk of breast cancer in adult life. We conducted a two-sample Mendelian randomisation (MR) study to assess whether this association is causal. Sixty independent single nucleotide polymorphisms (SNPs) known to be associated at P < 5 × 10 −8 with BW were used to construct (1) a 41-SNP instrumental variable (IV
A limitation of current LoRa networks is their single-hop nature. This causes difficulties in areas with poor Internet access, such as remote rural areas, or challenging radio environments, for example in metropolitan areas, as the LoRa gateway must be placed at a location with backhaul access to the network server, but must nonetheless be reachable by all end devices. To facilitate these applicat
Adverse weather conditions can cause deterioration of wireless channels, leading to reduced link capacities. Unlike in other types of networks, in radio-based wireless mesh networks, the link capacities depend not only on the prevailing conditions, but also on interfering transmissions, as well as the transmission power and modulation and coding schemes used. This leads to increased difficulty in Adverse weather conditions can cause deterioration of wireless channels, leading to reduced link capacities. Unlike in other types of networks, in radio-based wireless mesh networks, the link capacities depend not only on the prevailing conditions, but also on interfering transmissions, as well as the transmission power and modulation and coding schemes used. This leads to increased difficulty in
Background: The characteristics and prognosis of healthy obesity (HO) still remain unclear. We aimed to examine the characteristics of healthy severe obesity (HSO), defined by a novel approach, with a focus on self-reported physical activity (PA) and a genetic risk score for type 2 diabetes (GRS DM2). Methods: A cross-sectional analysis was carried out in a subsample of severly obese subjects (BMI
Angiopoietin-like 4 (ANGPTL4) is an endogenous inhibitor of lipoprotein lipase that modulates lipid levels, coronary atherosclerosis risk, and nutrient partitioning. We hypothesize that loss of ANGPTL4 function might improve glucose homeostasis and decrease risk of type 2 diabetes (T2D). We investigate protein-altering variants in ANGPTL4 among 58,124 participants in the DiscovEHR human genetics s
