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Group A streptococcus (GAS) is a major bacterial pathogen responsible for both local and systemic infections in humans. The molecular mechanisms that contribute to disease heterogeneity remain poorly understood. Here we show that the transition from a local to a systemic GAS infection is paralleled by pathogen-driven alterations in IgG homeostasis. Using animal models and a combination of sensitiv

Background and Aims: The triggering factors of sepsis-induced myocardial dysfunction (SIMD) are poorly understood and are not addressed by current treatments. S100A8/A9 is a pro-inflammatory alarmin abundantly secreted by activated neutrophils during infection and inflammation. We investigated the efficacy of S100A8/A9 blockade as a potential new treatment in SIMD. Methods: The relationship betwee

To meet the ever-increasing user demand, eleven of the fifteen European Spallation Source (ESS) instruments under construction aim to offer polarised neutrons for user experiments. They include an imaging instrument, a SANS instruments, two reflectometers, three diffractometers, and four spectrometers. In conjunction with in-kind contributions and instrumentation grants, the ESS Polarisation Proje

Solid fuel fired fluidized bed (FB) boilers are common in combined heat and power (CHP) plants in district heating- and process industry. In this study, utilization of such FB boilers for production of syngas in dual fluidized bed gasifiers and subsequent catalytic biofuel production to substitute natural gas (SNG), methanol (MeOH) and Fischer-Tropsch fuel (FT) has been examined. Based on the hypo

Because incubation by birds is energetically costly, parents frequently trade off investment in incubation against self-maintenance. This can be manifested by a reduction in incubation temperature, which comes at high somatic costs for nestlings. The extent to which these costs constrain fitness is poorly understood. We incubated wild blue tit clutches at three biologically relevant temperatures a

Integration of Infant Metabolite, Genetic, and Islet Autoimmunity Signatures to Predict Type 1 Diabetes by Age 6 Years The Journal of Clinical Endocrinology & Metabolism, 2022, XX, 1–10 https://doi.org/10.1210/clinem/dgac225 Advance access publication 25 April 2022 Clinical Research Article Received: 4 June 2021. Editorial Decision: 5 April 2022. Corrected and Typeset: 7 May 2022 © The Author(s) 2

https://www.teddy.lu.se/sites/teddy.lu.se/files/2023-02/141%20Webb-Robertson_JCEM_2022.pdf - 2026-06-07

Here, you can find courses that are open for incoming exchange students at the Faculty of Social Sciences. Semesters and periodsThe official academic year at Lund University is divided into two semesters (autumn and spring), each lasting 20 weeks.Autumn semester 2026Semester dates: 31 August 2026 – 17 January 2027Study period 1: 31 August – 1 NovemberStudy period 2: 2 November – 17 JanuarySpring s

https://www.sam.lu.se/en/education/exchange-studies/incoming-exchange-students/faculty-courses-exchange-students - 2026-06-05

Dean Contact details Email: henrik [dot] wenander [at] jur [dot] lu [dot] se Phone: +46 46 222 11 13Organisation Faculty of Law Room number: 511 Service point: 56 WebpageHenrik Wenanders profile in Lund University research portalOther affiliations Chair Faculty Board of Law Research coordinator Public Law Professor Department of Law Publications Displaying of publications. Sorted by year, then tit

https://www.law.lu.se/henrik-wenander - 2026-06-06

Head of department Contact details Email: anna [dot] lundberg [at] soclaw [dot] lu [dot] se Mobile: +46 70 946 62 30Organisation Sociology of Law Department Service point: 31 WebpageAnna Lundbergs profile in Lund University research portalOther affiliations Professor Sociology of Law Department Profile area member LU Profile Area: Human rightsResearch AreasCollective rights mobilisation and migrat

https://www.soclaw.lu.se/en/anna-lundberg - 2026-06-06

In this study of human carotid endarterectomy plaques (using 1128 regions of interest in a total of 10 plaques), we found that photon counting computed tomography (PCCT) can differentiate between attenuation and the spectral patterns of calcium, intra-plaque haemorrhage, thrombus, fibrosis, necrosis and lipid core. This is the first study to show the potential of PCCT in living patients using clin

Purpose: To investigate if hip and knee alignment assessed 2 years after anterior cruciate ligament (ACL) injury is associated with compartment-specific radiographic knee osteoarthritis (OA) 3 years later. Methods: An exploratory analysis was conducted in the knee ACL, nonsurgical versus surgical treatment (KANON) trial (ISRCTN84752559); 115 subjects with acute ACL injury were assessed at the 2-ye

AIMS: Vascular atherosclerotic calcification is a pathological process marked by the abnormal deposition of calcium minerals in the intima. Asporin (ASPN) is a small leucine-rich proteoglycan which interacts with collagen and calcium. Due to its role in matrix mineralization, we hypothesized that ASPN might act as a regulator of vascular calcification, thereby promoting atherosclerotic plaque stab

Dominant-inactivating mutations in the colony stimulating factor-1 receptor (CSF1R) cause CSF-1R related leukoencephalopathy (CRL), an adult-onset neurodegenerative disease that is modeled in the Csf1r+/– mouse. CRL is caused by microglial dysfunction. However, the primary microglial deficit, is unknown. To address this question, we employed single-nucleus RNA sequencing of brains from young Csf1r

Atrial fibrillation (AF) is the most common heart rhythm abnormality and is a leading cause of heart failure and stroke. This large-scale meta-analysis of genome-wide association studies increased the power to detect single-nucleotide variant associations and found more than 350 AF-associated genetic loci. We identified candidate genes related to muscle contractility, cardiac muscle development an

Housing preferences in later life vary, and housing decisions are complex. While much attention has been paid to health and accessibility, less is known about how financial factors influence housing decisions among older homeowners. This qualitative study aimed to deepen understanding of how single-family homeowners aged 55 and older reason about their housing situation. We conducted focus groups

Objectives: – To quantify the risk of incident psychiatric morbidity after community-acquired sepsis and assess whether new chronic diseases mediate the association. Design: – Nationwide, population-based matched register cohort; hazards estimated with weighted Cox regression. Setting: – Sweden, linking the National Quality Sepsis Registry, National Patient Register, Prescribed Drug Register, and

Immune checkpoint inhibitors (ICIs), targeting checkpoint receptors such as programmed cell death protein 1 (PD-1), are associated with increased risk of cardiovascular events, but the underlying mechanisms remain poorly understood. Here we show that PD-1 + T cells from murine atherosclerotic aortas mainly display a progenitor exhausted phenotype (PD-1 intSlamf6 +Tim3 -), produce IFNγ in vivo, exh

Knowledge about food structures at different length scales is key for the continued development of sustainable, tasty and healthy foods. It is critical to control, model and predict the supramolecular architecture of foods along the whole value chain: from raw materials, to their changes during processing, all the way to how products form structures during consumption and digestion. Today, advance