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Popular Abstract in Swedish Traditionellt har effekten av behandling inom kärlkirurgi främst utvärderats med objektiva mått, som till exempel beräkning av ankelindex och gångsträcka. Dessa data ger värdefull information men de återger inte hur patientens klarar sitt dagliga liv eller hur behandling återverkar på deras livskvalitet. Detta styrks i tidigare forskning som visar att korrelationen mellThe aim of this thesis was to assess quality of life in patients with varying degrees of lower limb ischaemia before and after revascularisation, to assess quality of life in relation to the degree of ischaemia and the respondents’ sense of coherence (SOC) and in comparison with a healthy control group, and to compare two different quality of life instruments regarding their usefulness as outcome

Popular Abstract in Swedish Huden och slemhinnor (mukosa) fungerar som kroppens skyddsbarriärer mot yttre angrepp av mikrober, makromolekyler och toxiner och förhindrar dessa att nå inre organ. Trots ett massivt immunskydd sker de flesta infektioner på slemhinnornas ytor. I blodcirkulationen förekommer fem olika typer av vita blodkroppar, alla med olika roller i immunförsvaret. I varje blod finns Mucosal infections trigger an inflammatory response that includes the secretion of cytokines and the recruitment of neutrophils to the infected site. This thesis describes studies examining the molecular mechanisms of neutrophil migration to sites of mucosal bacterial infection. Escherichia coli (E. coli) infection of epithelial cell layers stimulates chemokine secretion and chemokine receptor ex

Recent studies have identified a number of transcriptional regulators, including E2A, early B-cell factor 1 (EBF1), FOXO1, and paired box gene 5 (PAX5), that promote early B-cell development. However, how this ensemble of regulators mechanistically promotes B-cell fate remains poorly understood. Here we demonstrate that B-cell development in FOXO1-deficient mice is arrested in the common lymphoid

Popular Abstract in Swedish Streptococcus pyogenes (GAS) är en viktig sjukdomsframkallande bakterie som orsakar alltifrån lindriga infektioner som halsfluss (tonsillit) och svinkoppar (impetigo) till livshotande djupa infektioner som nekrotiserande fasceit eller ”Toxic shock syndrom”. På grund av det snabba sjukdomsförloppet i de livshotande infektionerna har streptokockerna fått beteckningen ”mörA distinguishing feature of Streptococcus pyogenes (GAS) is their ability to resist phagocytosis in whole human blood in the absence of type-specific antibodies, a property that is dependent on the expression of the surface associated M proteins. A common characteristic of M proteins is their interaction with a variety of host proteins including the complement regulatory protein factor H (FH) and

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Hereditary complete deficiency of complement component C1q is associated with a high prevalence of systemic lupus erythematosus and increased susceptibility to severe recurrent infections. An 11-year-old girl was screened for immunodeficiency due to a history of recurrent meningitis and pneumonia. Immunologic studies revealed absence of classic pathway hemolytic activity and undetectable levels of

This paper provides a systematic review of scholarly literature concerning the enforcement of children’s rights in the classroom context and school management. The literature review is based on a systematic review methodology the authors developed drawing on the methods and guidelines used in the medical sciences over the last 15 years. Forty-two articles published between 1990 and 2014 were selec

Aging of the hematopoietic stem cell compartment is believed to contribute to the onset of a variety of age-dependent blood cell pathophysiologies. Mechanistic drivers of hematopoietic stem cell (HSC) aging include DNA damage accumulation and induction of tumor suppressor pathways that combine to reduce the regenerative capacity of aged HSCs. Such mechanisms do not however account for the change i

The diagnosis of pulmonary tuberculosis (TB) relies on the bacteriological examination of sputum. However, microscopy of smears made directly from sputum has a low sensitivity and there is an urgent need for improved methods. We have compared microscopy of smears made directly from sputum with microscopy after liquefaction of sputum with household bleach (NaOCl) and concentration of bacteria by ce

The lack of human resources is one of the main bottlenecks to achieving the Millennium Development Goals on maternal and child health. A coherent national policy, recognized across government, needs to be in place to overcome this especially in countries severely affected by HIV/AIDS. Such a policy should cover selection of pre-service students, the qualifications of trainers and training sites, s

Insulin sensitivity and secretion are related in a curvilinear inverse asymptotic function. However, the signaling factors mediating this relation are not known. In this study, we explored whether circulating glucose, lipids or two adipocyte-derived hormones, leptin and adiponectin, are related to the curvilinear function between insulin sensitivity and secretion in subjects with normal glucose to

Two series of C3-benzamido and O2-anion-substituted galactopyranosides were synthesized and studied as binders to arginine-rich proteins galectin-1, -3, -7, -8N (N-terminal domain), and -9N (N-terminal domain). The first series had a 4-methylbenzamide at C3 and the anionic O2-substituent was varied. The second series varied the 4-substituent of the C3-benzamide, whereas the anionic O2 substituent

Streptococcus pyogenes is an important human pathogen frequently colonizing the throat and skin of humans. To facilitate colonization and spread and to avoid the host immune defence, streptococci are endowed with a variety of virulence factors, two of which are investigated in this thesis namely streptolysin O (SLO) and M protein. SLO is a secreted cytolysin that forms pores in eukaryotic membran

Energy consumption reduction is today an important design issue for all kinds of digital systems. Offering both flexibility and efficient energy management, variable speed processor architectures are prefered for low energy consumption even in hard real-time systems. For this type of systems, the main approach consists in trading speed for lower energy while meeting all deadlines. For tasks with v

In our research we investigate rational agent which consciously balances deliberation and acting, and uses learning to augment its reasoning. It creates several partial plans, uses past experience to choose the best one and, by executing it, gains new knowledge about the world. We analyse a possible application of Inductive Logic Programming to learn how to evaluate partial plans in a resource-con