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The fate options of hematopoietic stem cells (HSCs) include self-renewal, differentiation, migration, and apoptosis. HSCs self-renewal divisions in stem cells are required for rapid regeneration during tissue damage and stress, but how precisely intracellular calcium signals are regulated to maintain fate options in normal hematopoiesis is unclear. S100A6 knockout (KO) HSCs have reduced total cell
CONTEXT: Fear of pain resonates with most people, in particular, in relation to dying. Despite this, there are still people dying with unrelieved pain.OBJECTIVES: We quantified the risk, and investigated risk factors, for dying with unrelieved pain in a nationwide observational cohort study.METHODS: Using data from Swedish Register of Palliative Care, we analyzed 161,762 expected deaths during 201
Josefin GoochProtecting Ecological Integrity in Transboundary Watercourses:An Intergrational Approach towards Implementing Environmental FlowsDatum för disputation: måndagen den 14 november 2016Fakultetsopponent: professor Dan Tarlock, Chicago-Kent College of Law, Illinois Institution of Technology, ChicagoÄmne: internationell miljörättAbstractThe thesis explores the obligation in international la
https://www.jur.lu.se/forskning/disputationer/disputationer-2016 - 2026-06-29
PURPOSE: Irradiation inflicts acute injuries to the intestinal mucosa with rapid apoptosis induction and subsequent reduction in epithelial surface area. It may therefore be assumed that the intestinal barrier function is affected. The aim of this study was to compare the mucosal permeability in irradiated rectum and nonirradiated sigmoid colon from patients subjected to radiation therapy before s
We report the discovery that V2331 Cygni is not an L star but an eclipsing variable with deep minima, and present a determination of the elements of the star: Epoch = HJD 2456184.296 ±0.001 and Period = 1.3886 ± 0.0001 days.
A highly active zinc glutarate-double metal cyanide (DMC) composite catalyst (ZnGA/Zn-CrDMC) was designed for the carbon dioxide (CO2) and propylene oxide (PO) copolymerization reaction. The composite catalyst was synthesized in a rheological phase reaction and characterized using Fourier transform infrared spectroscopy (FT-IR), powder X-ray diffraction (PXRD), and scanning electron microscopy (SE
Head and neck squamous cell carcinoma (HNSCC) is known to cause substantial immunosuppression. The present study was designed to characterize blood leukocyte activation in HNSCC and to investigate if the individual activation pattern could be related to tumor progress and survival. The leukocyte activation profile of HNSCC patients and healthy controls was assessed with flow cytometry. HNSCC patie
By building a strong brand that is favourably perceived by target customers, a firm can establish a competitive advantage that enables greater revenues and profitability. This is at least what the branding literature always has assumed, and something few marketing and brand managers seem to disagree with. When asked how exactly a brand can be charged with such great value, however, neither academi
Context: The biological mechanism for the association between sleep duration and incident diabetes mellitus (DM) is unclear. Sleep duration and Caspase-8, a marker of apoptotic activity, have both been implicated in beta cell function.Objective: To investigate the associations between sleep duration and plasma Caspase-8, and incident DM, respectively.Design: Prospective cohort study.Setting: The M
Multiple missiles were fired at Erbil on February 15, killing at least one civil contractor and injuring at least one American national. It is likely that the attack was conducted by an Iranian proxy in order to put pressure on President Biden to lift the sanctions against the country and return to the 2015 nuclear deal.
South Korea is attempting to deal with the now-universal issue of disinformation. So why did its draft bill attract such fierce criticism?
Much of the improvement in living standards in developed and developing countries is attributable to the exploitation of nonrenewable and renewable resources. The problem is to know when the exploitation occurs at rates and with technologies that are sustainable. If the technologies used are not sustainable, resource exploitation presents a serious problem for the future because welfare will decre
In the first of two essays in this Journal, I seek to unify the historical geography of early modern 'European expansion' (Iberia and Latin America) with the environmental history of the 'transition to capitalism' (northwestern Europe). The expansion of Europe's overseas empires and the transitions to capitalism within Europe were differentiated moments within the geographical expansion of commodi
Key design features of high performance houses are investigated for improving energy efficiency in cold climates. Reference dwellings with typical constructions and system designs are compared with high performance houses using the best technology available. The dwellings used for reference are a multi-family apartment building and a single-family detached house, designed according to a mix of Nor
This thesis studies the efforts made by society to achieve more efficient energy use in order to better utilise resources and lessen the stress on the environment. Despite the value to society promised by more efficient energy use, too few attempts are made at realising this value. One instrument available to governments in their efforts to stimulate efficiency schemes, is to encourage energy comp
Electron transporting layers facilitating electron extraction and suppressing hole recombination at the cathode are crucial components in any thin-film solar cell geometry, including that of metal–halide perovskite solar cells. Amorphous tantalum oxide (Ta2O5) deposited by spin coating was explored as an electron transport material for perovskite solar cells, achieving power conversion efficiency
The steel and chemical production industries are the largest industrial emitters of greenhouse gases in the European Union, together accounting for half of the EU’s industrial greenhouse gas (GHG) emissions. A promising strategy for achieving deep GHG emissions reductions is the electrification of these two industries, which would depend on the rapid expansion of renewable electricity supply. Such
