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Creatine kinases are important in maintaining cellular-energy homeostasis, and neuroprotective effects have been attributed to the administration of creatine and creatine-like compounds. Herein we examine whether ablation of the cytosolic brain-type creatine kinase (B-CK) in mice has detrimental effects on brain development, physiological integrity or task performance. Mice deficient in B-CK (B-CK

Fuel-cycle emissions of carbon dioxide (CO2) carbon oxide (CO), nitrogen oxides (NOx), sulphur dioxide (SO2), hydrocarbons (HC), methane (CH4), and particles are analysed from a life-cycle perspective for different biogas systems based oil six different raw materials. The gas is produced in large- or farm-scale biogas plants, and is used in boilers for heat production, in turbines for co-generatio

Lactic acid bacteria constitute a diverse group of industrially significant, safe microorganisms that are primarily used as starter cultures and probiotics, and are also being developed as production systems in industrial biotechnology for biocatalysis and transformation of renewable feedstocks to commodity- and high-value chemicals, and health products. Development of strains, which was initially

The production and use of transportation fuels can lead to sustainability impacts. Assessing them simultaneously in a holistic way is a challenge. This paper examines methodology for assessing the sustainability performance of products in a more integrated way, including a broad range of social impacts. Life Cycle Sustainability Assessment (LCSA) methodology is applied for this assessment. LSCA of

Accurate prediction on the pressurized discharge performance is significant to the safety operation of cryogenic propellant system. In the present study, a two-dimensional numerical model is established to simulate the fuel outflow with high-temperature gas injection. Both the environmental heat invasion and interfacial phase change are detailedly considered. The volume of fluid method is used to

Wind energy is a rapidly growing field of renewable energy, and as such, intensive scientific and societal interest has been already attracted. Research on wind turbine structures has been mostly focused on the structural analysis, design and/or assessment of wind turbines mainly against normal (environmental) exposures while, so far, only marginal attention has been spent on considering extreme n

Photoinduced phase separation, which limits the available band gap energies for photovoltaic applications, was reported for a range of mixed-halide perovskites. A microscopic understanding of the phase separation mechanism is still lacking but may be beneficial to rationalize limitations as well as enable the design of phase-stable perovskite semiconductors. In this letter, electron-beam-induced p

The built environment accounts for approximately 32 % of the global final energy use but also holds great potential for energy efficiency still to be harnessed (Lucon et al., 2014). To develop innovative policies for energy efficiency that are capable of realizing transformative changes, we argue that there is an urgent need for new systemic evaluation frameworks that provide learning and knowledg

CONTEXT: Fear of pain resonates with most people, in particular, in relation to dying. Despite this, there are still people dying with unrelieved pain.OBJECTIVES: We quantified the risk, and investigated risk factors, for dying with unrelieved pain in a nationwide observational cohort study.METHODS: Using data from Swedish Register of Palliative Care, we analyzed 161,762 expected deaths during 201

Renewable energies can play an important role to provide electricity to rural communities. This work-study the optimum design of a hybrid hydro-wind, micro-power system in rural area. Six case studies, including the impact of hydro head, flow rate, efficiency, and head loss for micro hydropower with wind turbine hub height were implemented based on HOMER software. The simulation results show the i

The fate options of hematopoietic stem cells (HSCs) include self-renewal, differentiation, migration, and apoptosis. HSCs self-renewal divisions in stem cells are required for rapid regeneration during tissue damage and stress, but how precisely intracellular calcium signals are regulated to maintain fate options in normal hematopoiesis is unclear. S100A6 knockout (KO) HSCs have reduced total cell

Energy-efficient building designs, notably through adding insulation, can reduce energy consumption and greenhouse gas emissions by over 40 %, but may also increase risk of condensation. Therefore, a comprehensive decision analysis approach is essential for selecting optimal building envelope assemblies while considering their hygrothermal, economic, and environmental implications. This study intr

This paper investigates the dynamics surrounding energy efficiency measures in building renovation projects to understand how energy issues are dealt with at planning and design meetings for building renovations. Through a comparative analysis of case studies of residential building renovation projects in Sweden and Denmark, document studies, observations, and interviews were conducted. The study

Youth are official stakeholders of global environmental politics (GEP) since 1992, and several youth platforms have been created within the framework of the United Nations since the 2000s. However, recently, the oppositional voice of youth, through climate protests, has increased worldwide. While official youth platforms have been active over the years, this article asks to which extent they mitig

The C programming language, while offering high performance and low-level control, is memory-unsafe. This makes it prone to programming errors that can result in serious software vulnerabilities and system instability. In this paper, we investigate the feasibility of transitioning a large code base from C to a memory-safe alternative, specifically Rust, in the context of a large company in telecom

Fires involving electric vehicles have attracted considerable attention in the media. In particular, the toxic gases released upon combustion of electric vehicles and lithium-ion batteries has been a major concern. In this study, the results of six large-scale vehicle fire tests are presented including three electric vehicles, two internal combustion engine vehicles, and one electric vehicle with

The rising awareness of climate challenges and resource constraints has strengthened interest in the circular economy (CE), characterized as an economic system aimed to minimize the depletion of the world’s natural resources through processes of value retention and value regeneration. Because CE research originated in the engineering field, studies to date have mostly focused on technical and mana

The key message is the importance of a systemic approach to handling water and energy together, both in design and in oper-ation. The paper demonstrates how renewable energy, solar photovoltaic (PV) and solar thermal, in combination with a small nutrient removal plant, provides a reliable solution for small-scale decentralized water recovery operations. The system is automated and can operate outs

Hybrid ventilation systems have become increasingly attractive, because they are considered to provide good indoor air quality (IAQ) with low energy consumption. In this study, we evaluate the performance of a hybrid ventilation system (operating on both mechanical and natural ventilation mode) by monitoring the IAQ (e.g. temperature, humidity, CO2 levels) and the energy consumption of a multifami