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The meiotic functions of Emi2, an inhibitor of the APC/C complex, have been best characterized in oocytes where it mediates metaphase II arrest as a component of the cytostatic factor. We generated knockout mice to determine the in vivo functions of Emi2—in particular, its functions in the testis, where Emi2 is expressed at high levels. Male and female Emi2 knockout mice are viable but sterile, in

Perlecan is a heparansulfate proteoglycan found in basement membranes, cartilage, and several mesenchymal tissues that form during development, tumour growth, and tissue repair. Loss-of-function mutations in the perlecan gene in mice are associated with embryonic lethality caused primarily by cardiac abnormalities probably due to hemopericards. The aim of the present study was to investigate the m

Neurocan is a component of the extracellular matrix in brain. Due to its inhibition of neuronal adhesion and outgrowth in vitro and its expression pattern in vivo it was suggested to play an important role in axon guidance and neurite growth. To study the role of neurocan in brain development we generated neurocan-deficient mice by targeted disruption of the neurocan gene. These mice are viable an

Understreckare om den yazidiska tragedin

It is obviously expected that sustainable development is the primary target to raise prosperity and life standards of nations. It is necessary to ensure social, political, and economic stability. But what about the stimulus factors that motivate sustainable development? Can income inequality be one of them? Some literature has examined the role of income distribution on economic growth, but to te

Water is a necessity for human survival, and a lack of sufficient clean water can have severe negative impacts on human health, economic activity, food security and societal relations. Increasing demand on water resources around the globe often leads to conflicts between different water users who compete for available supplies. The Murray Darling Basin (MDB) in Australia is an area that faces many

The transmembrane protein Dystroglycan is a central element of the dystrophin-associated glycoprotein complex, which is involved in the pathogenesis of many forms of muscular dystrophy. Dystroglycan is a receptor for multiple extracellular matrix (ECM) molecules such as Laminin, agrin and perlecan, and plays a role in linking the ECM to the actin cytoskeleton; however, how these interactions are r

Paper presented at Swedish Anthropological Association Annual Meeting, Lund, April 2015, panel on Business ethics. Abstract: Under the influence of U.S. government regulations, new anti-bribery laws and embarrassing corruption scandals, major global corporations have realized that unethical conduct may affect their reputations and ultimately, their profits. This development has given rise to a new

Aquaporins (AQPs) are membrane channel proteins that transport water and uncharged solutes across different membranes in organisms in all kingdoms of life. In plants, the AQPs can be divided into seven different subfamilies and five of these are present in higher plants. The most recently characterized of these subfamilies is the XIP subfamily, which is found in most dicots but not in monocots. In

Avdelningen för klinisk genetik består av flera forskargrupper. Vår forskning är inriktad mot olika aspekter av tumörgenetik och tumörbiologi samt genetiska orsaker till ärftliga sjukdomar. Dessa studier syftar till att förbättra diagnostik, behandling och uppföljning av patienter med tumörsjukdom samt till att förbättra utredning och behandling av ärftliga sjukdomar för såväl patienterna som deraThe Division of Clinical Genetics consists of several research teams. Our research is focused on different aspects of cancer genetics and cancer biology as well as genetics of heritable rare diseases. This includes the identification and characterization of genetic aberrations, investigations of the functional outcome of somatic and constitutional genetic variants, and the development of novel tar

Avdelningen för högskolepedagogisk utveckling (AHU) ingår i Institutionen för utbildningsvetenskap. AHU ersätter från 2016 CED (Centre for Educational Development). AHU:s huvuduppgift är att bedriva högskolepedagogisk utveckling i form av praxisnära utvecklingsarbete, högskolepedagogisk utbildning för lärare och doktorander samt forskning inom området. Avdelningen samarbetar med fakulteterna och öAHU, short for the Division for Higher Education Development at Lund University, was founded in 2016. It is included in the department for Educational Sciences at the Joint Faculties of Humanities and Theology. AHU replaces CED, Centre for Educational Development. The main task for AHU is to support academic development at the university by offering pedagogical courses to academic teachers and doc

Huvudområden: Ingenjörsgeologi, tillämpad geofysik, förundersökningsmetodik samt hydrogeologi och geotermisk energi. Tillämpad geofysik inom områdena seismoakustik, marin mätteknik, geoelektrik, seismik, loggingteknik och radarmätteknik. För- och fältundersökningsmetodik med avseende på geofysiska och geologiska metoders integration i geotekniska, bergmekaniska och hydrogeologiska problemställning