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There is compelling evidence to suggest that estrogen administration to women of climacteric age reduces subsequent myocardial infarction by some 50%. Accumulating data also suggests estrogens confer substantial protection from stroke. Given this rationale, it is prudent to suggest to regulatory bodies that estrogen treatment would have this indication. Estrogens have other well-defined, and less
The glymphatic system is a highly polarized cerebrospinal fluid (CSF) transport system that facilitates the clearance of neurotoxic molecules through a brain-wide network of perivascular pathways. Herein we have mapped the development of the glymphatic system in mice. Perivascular CSF transport first emerges in hippocampus in newborn mice,
Aortoenteric fistula formation is a devastating condition regardless of whether it is primary or secondary (i.e. after previous aneurysm repair) in nature. Patients present with signs and symptoms of gastrointestinal bleeding with or without signs of systemic infection and are often in a very poor clinical condition. Conventional treatment consists of extensive open surgery (extra-anatomical bypas
Avdelningen för Teknisk Vattenresurslära bedriver utbildning och forskning inom Kusthydraulik, Urban Hydrologi, etc.The division of Water Resources Engineering work with education and research within Coastal Hydraulics, Urban Hydrology, etc.
Abstract: The FIFA World Cup, together with the Summer Olympic Games, are the two events classified as sports mega-events (SMEs), characterized by their global outreach and different types of costs. Within the SME realm, a paradoxical trend can be seen; they show stronger sustainability agendas, yet generate higher social, economic, and environmental costs. The overarching question is their legaci
Within the circular economy, alternatives to fast-fashion include second-hand clothing consumption. The narratives surrounding second-hand clothing have shifted from the stigma of old, dirty, smelly clothing to trendy, sustainable, and bargain items. The environmental benefits of second-hand are realised through the increased use-intensity and avoided production of new garments. However, these ben
Certain oxygenated compounds, called oxygenates, when blended with gasoline, have the ability to inhibit the occurrence of engine knock, thus helping improve spark-ignition engine efficiency. Similarly, oxygenates can also be added to diesel fuel to decrease the exhaust emissions—soot in particular—from diesel engines. Although ethanol and biodiesel have had widespread use as oxygenates for gasoli
Centrum för ekonomisk demografi består av ett trettiotal medarbetare inom ekonomisk historia, nationalekonomi, samhällsmedicin, social arbete och statistik som i sin forskning tar upp ekonomiska samhällsfrågor med koppling till demografi ur ett historiskt och internationellt perspektiv. 2006 beviljades centret ett av de 20 s.k. Linnéstöd som ingår i Vetenskapsrådets nya satsning på långsiktig finaThe Centre for Economic Demography consists of more than thirty collaborators in economic history, economics, social medicine, social work and statistics that in their research focus on socioeconomic issues from a historical and international demographic perspective. In 2006 the Centre was awarded one of the so-called Linnaeus grants that form part of the Swedish Research Councils new emphasis on
Uroteliala cancer, cancer i urinblåsan, är indelad i två större typer, icke-muskelinvasiv och muskel-invasiv cancer, med skilda biologiska och kliniska egenskaper. Prognos och behandling är i huvudsak baserade på patologiska kriterier. Det faktum att endast 20-25% av höggradiga tumörer med lågt tumörstadium bekräftas efter patologisk eftergranskning, och att 30% av patienterna med intermediärt tumUrothelial cancer, bladder cancer, is divided in two major subtypes, non-muscle invasive and muscle-invasive, with very distinct biological and clinical properties. Prognosis and treatment are mainly based on pathological criteria. The fact that only 20-25% of high grade low stage tumors are confirmed by review pathology, and that 30% of patients with intermediate stage tumors are upstaged after r
Using a new dataset on fossil fuel funding, this paper examines bank responses to Germany’s 2020 coal phase-out decision. German banks reduced fossil fuel financing relative to other banks but not coal funding. Globally, banks increased underwriting for coal companies relative to other fossil fuel firms. Firms with entirely coal-based post-sample power production received more funding, indicating
The predicament in which we find ourselves today is that many professionals lack a sufficient grounding in formal methods, tools and techniques to enable them to make an appropriate selection for different kinds of problem. This can mean that complexity remains unrecognized and ambiguous problem situations are addressed as if they were clear and straightforward, resulting in inadequate solutions t
The meiotic functions of Emi2, an inhibitor of the APC/C complex, have been best characterized in oocytes where it mediates metaphase II arrest as a component of the cytostatic factor. We generated knockout mice to determine the in vivo functions of Emi2—in particular, its functions in the testis, where Emi2 is expressed at high levels. Male and female Emi2 knockout mice are viable but sterile, in
Perlecan is a heparansulfate proteoglycan found in basement membranes, cartilage, and several mesenchymal tissues that form during development, tumour growth, and tissue repair. Loss-of-function mutations in the perlecan gene in mice are associated with embryonic lethality caused primarily by cardiac abnormalities probably due to hemopericards. The aim of the present study was to investigate the m
Neurocan is a component of the extracellular matrix in brain. Due to its inhibition of neuronal adhesion and outgrowth in vitro and its expression pattern in vivo it was suggested to play an important role in axon guidance and neurite growth. To study the role of neurocan in brain development we generated neurocan-deficient mice by targeted disruption of the neurocan gene. These mice are viable an
