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The modern use of neoadjuvant and conversion systemic therapy in patients with colorectal cancer liver metastasis (CRLM) has improved resection rates and changed the borders between “resectable” and “unresectable” disease. Also, the use of preoperative systemic therapy has resulted in an increased frequency of disappearing liver metastasis (DLM). The optimal management of DLM is still controversia

Introduction Sweden, as many other high-income countries, has adopted guidelines to offer induction of labour at 41+0 gestational weeks to decrease the risk for perinatal death. As more than 20% of the pregnant population reach this gestational age, and along with other contributing factors, induction rates have increased up to 30% in many countries. Both women and care providers have raised the q

This chapter critically examines a number of ethical dilemmas at stake for professionals working with refugee children and families in Denmark within the field of early childhood education. While national guidelines promote diversity by framing cultural differences as valuable resources, integration policies often result in efforts aimed at assimilation. The chapter explores how everyday ethical j

Nocturia, the urge to wake from sleep to void, is targeted sub-optimally by existing drugs that modulate circadian dysregulation of urine production in kidney without alleviating detrusor overactivity, a key aspect in the multifactorial etiology of nocturia. This study reports age-related upregulation of arginine vasopressin (AVP) synthesis in mouse urinary bladder to counter the concurrent declin

Objective: Ampullary neoplastic lesions can be resected by endoscopic papillectomy (EP) or transduodenal surgical ampullectomy (TSA) while pancreaticoduodenectomy is reserved for more advanced lesions. We present the largest retrospective comparative study analysing EP and TSA. Design: Of all patients in the database, lesions with prior interventions, benign histology advanced malignancy (T2 and m

Purpose: To present the outcomes of a randomised clinical trial for the treatment of progressive keratoconus using different kinds of riboflavin and the addition of sterile water in thin corneae. Methods: A randomised study using epithelium-off corneal cross-linking (CXL) with continuous UVA irradiance 9 mW/cm2 for 10 min (total fluence 5.4 J/cm2) and two kinds of riboflavin solutions: (i) isoosmo

Background: Fine-needle aspiration biopsy (FNAB) of lymph nodes is a widely used method for evaluating lymphadenopathy. FNAB offers general advantages of rapid turnaround time, low cost and minimal morbidity, and more specific advantages in various clinical situations, such as deeply located lymph nodes or patients with significant comorbidities. The FNAB sample can be utilized for a wide range of

Introduction: Accurate and reproducible measures of factor activity are required to guide clinical decision-making following gene therapy for haemophilia B (HB). Highly significant discrepancies have been observed in measurements of various factor IX (FIX) concentrates that carry molecular modifications to extend their half-life, arguing for the need for careful analysis of new HB treatment modali

Background: Proton beam therapy (PBT) offers dosimetric advantages in pediatric radiotherapy by reducing radiation exposure to healthy tissues. However, broad implementation raises important ethical, logistical, and equity considerations, especially in settings with limited access to advanced technologies. Procedure: This position paper by the Paediatric Radiation Oncology Society (PROS) reviews t

Background: Lung injury in COVID-19 is characterized by neutrophil invasion and the release of neutrophil extracellular traps (NETs). An aberrant NET formation may induce local inflammation and increase sputum viscosity. Inhalation of DNase I (dornase alfa) is a treatment option that degrades NETs in the airways. Previous case series have indicated positive clinical effects of inhaled dornase alfa

Controllable hydrogen generation rate of Al-Ga-based on-site hydrogen supply materials significantly impacts their practical application. In many scenarios, the hydrolysis reaction occurs at elevated temperatures, which is a factor often overlooked in its effect on reaction kinetics. This study investigates the relationship between grain size and reaction rate in Al-Ga-based alloys for hydrogen ge

The Middle Danube (Carpathian) Basin is considered to encompass some of the thickest and most complete records of aeolian dust deposition in Europe, covering the last two glacial–interglacial cycles. In this study, independent, published chronologies based on absolute dating methods were compiled for 34 loess-palaeosol sequences and modelled using Bayesian statistics. Mass accumulation rates (MARs

Chrysene-containing polymers functionalized with piperidinium- and quinuclidinium cations, respectively, are prepared by polyhydroxyalkylation and studied as anion exchange membranes (AEMs). Experimental results, supported by theoretical considerations, indicate that the chrysene units significantly enhance alkaline stability; a poly(chrysene piperidinium) AEM shows only 16% total ionic loss, comp

A search for a new Z′ gauge boson predicted by Lµ-Lτ models, based on charged-current Drell-Yan production, pp→W±(∗)→Z′μ±ν→μ±μ μ±ν, is presented. The data sample used corresponds to an integrated luminosity of 140 fb-1 of proton-proton collisions at s=13 TeV recorded by the ATLAS detector at the Large Hadron Collider. The search examines a final state of 3μ plus large missing transverse momentum.

The European Association of Urology (EAU) 2021 prognostic model for non–muscle-invasive bladder cancer (NMIBC) is based on the World Health Organization (WHO) 1973 and/or WHO 2004/2022 grading systems for patients who did not receive bacillus Calmette-Guérin (BCG) instillations and is widely used to assess the risk of progression. The estimated risk of progression affects the type of adjuvant intr

Atmospheric methane (CH4) growth rates reached unprecedented values in the years 2020-2022. To identify the main drivers of this increase, an inverse modeling study estimated regional and sectoral emission changes for 2016-2022. Three inverse estimates based on different sets of atmospheric CH4 observations (surface observations only, surface and aircraft observations, and GOSAT observations) cons

Machine learning methods have a groundbreaking impact in many application domains, but their application on real robotic platforms is still limited. Despite the many challenges associated with combining machine learning technology with robotics, robot learning remains one of the most promising directions for enhancing the capabilities of robots. When deploying learning-based approaches on real rob