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Background: Lung injury in COVID-19 is characterized by neutrophil invasion and the release of neutrophil extracellular traps (NETs). An aberrant NET formation may induce local inflammation and increase sputum viscosity. Inhalation of DNase I (dornase alfa) is a treatment option that degrades NETs in the airways. Previous case series have indicated positive clinical effects of inhaled dornase alfa
Controllable hydrogen generation rate of Al-Ga-based on-site hydrogen supply materials significantly impacts their practical application. In many scenarios, the hydrolysis reaction occurs at elevated temperatures, which is a factor often overlooked in its effect on reaction kinetics. This study investigates the relationship between grain size and reaction rate in Al-Ga-based alloys for hydrogen ge
The Middle Danube (Carpathian) Basin is considered to encompass some of the thickest and most complete records of aeolian dust deposition in Europe, covering the last two glacial–interglacial cycles. In this study, independent, published chronologies based on absolute dating methods were compiled for 34 loess-palaeosol sequences and modelled using Bayesian statistics. Mass accumulation rates (MARs
Chrysene-containing polymers functionalized with piperidinium- and quinuclidinium cations, respectively, are prepared by polyhydroxyalkylation and studied as anion exchange membranes (AEMs). Experimental results, supported by theoretical considerations, indicate that the chrysene units significantly enhance alkaline stability; a poly(chrysene piperidinium) AEM shows only 16% total ionic loss, comp
A search for a new Z′ gauge boson predicted by Lµ-Lτ models, based on charged-current Drell-Yan production, pp→W±(∗)→Z′μ±ν→μ±μ μ±ν, is presented. The data sample used corresponds to an integrated luminosity of 140 fb-1 of proton-proton collisions at s=13 TeV recorded by the ATLAS detector at the Large Hadron Collider. The search examines a final state of 3μ plus large missing transverse momentum.
The European Association of Urology (EAU) 2021 prognostic model for non–muscle-invasive bladder cancer (NMIBC) is based on the World Health Organization (WHO) 1973 and/or WHO 2004/2022 grading systems for patients who did not receive bacillus Calmette-Guérin (BCG) instillations and is widely used to assess the risk of progression. The estimated risk of progression affects the type of adjuvant intr
Atmospheric methane (CH4) growth rates reached unprecedented values in the years 2020-2022. To identify the main drivers of this increase, an inverse modeling study estimated regional and sectoral emission changes for 2016-2022. Three inverse estimates based on different sets of atmospheric CH4 observations (surface observations only, surface and aircraft observations, and GOSAT observations) cons
Machine learning methods have a groundbreaking impact in many application domains, but their application on real robotic platforms is still limited. Despite the many challenges associated with combining machine learning technology with robotics, robot learning remains one of the most promising directions for enhancing the capabilities of robots. When deploying learning-based approaches on real rob
Amplification of the MYCN proto-oncogene serves as a key marker of aggressive disease and poor treatment outcomes in certain pediatric tumors originating from the nervous system, including neuroblastoma and medulloblastoma. However, the complex nature of the challenging MYCN protein underscores the urgent need for additional targets and therapies to tackle neuroblastoma and medulloblastoma. In thi
This chapter analyzes five cases in which the Turkish Constitutional Court banned political parties, advocating for equal citizenship rights for the Kurdish people, based on their alleged violation of the law on political parties, which prohibits claims of the existence of minorities. The chapter aims to explore the conceptualization of minority rights within the juridico-political realm of Turkey
A search for high-mass resonances decaying into a Formula Presented-lepton and a neutrino using proton-proton collisions at a center-of-mass energy of Formula Presented is presented. The full run 2 data sample corresponding to an integrated luminosity of Formula Presented recorded by the ATLAS experiment in the years 2015-2018 is analyzed. The Formula Presented-lepton is reconstructed in its hadro
A combination of searches for a new resonance decaying into a Higgs boson pair is presented, using up to 139 fb^{-1} of pp collision data at sqrt[s]=13 TeV recorded with the ATLAS detector at the LHC. The combination includes searches performed in three decay channels: bb[over ¯]bb[over ¯], bb[over ¯]τ^{+}τ^{-}, and bb[over ¯]γγ. No excess above the expected Standard Model background is observed
Agriculture faces a major challenge in meeting the world’s growing demand for food in a sustainable manner in the face of increasing environmental pressures, in particular the growing impact of climate change. Agriculture is also a major contributor to climate change. Digital technologies in agriculture can contribute to climate change adaptation and mitigation. This paper examines the interaction
Iran has yet to be the subject of research looking into the gaps in the nationality law, which, could create and perpetuate statelessness. There were however, several pre-identified populations, some members of which are believed to be affected by statelessness, as well as gender discrimination in the nationality law - which causes and increases the risk of rendering children stateless. Therefore,
BackgroundThere is a need to enhance access to and support for self-management of activities in everyday life after a stroke. Internet-based solutions have the potential to contribute to this development. Consequently, an internet-based intervention called Strategies for Empowering Activities in Everyday Life (SEE) was developed. The intervention aims to assist clients in developing management str
Time-series of high throughput gene sequencing data intended for gene regulatory network (GRN) inference are often short due to the high costs of sampling cell systems. Moreover, experimentalists lack a set of quantitative guidelines that prescribe the minimal number of samples required to infer a reliable GRN model. We study the temporal resolution of data vs. quality of GRN inference in order to
Purpose Pain in conjunction with surgery for ulnar nerve entrapment at the elbow is seldom highlighted in the literature. This study aimed to explore patients' experiences of living with chronic pain (≥3 months duration) in conjunction with surgery for ulnar nerve entrapment at the elbow, the consequences and the coping strategies applied. Material and methods In-depth interviews were conducted wi
Ongoing climate variability and change are increasing the burden of diarrhoeal disease worldwide. Meaningful early warning systems with adequate lead times (weeks to months) are needed to guide public health decision–making and enhance community resilience against health threats posed by climate change. Toward this goal, we trained various machine-learning models to predict diarrhoeal disease rate
