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Background. CRIM1 is a plasma membrane bound protein containing six cysteine-rich repeats (CRR). Through these, CRIM1 has been shown to interact with a subgroup of the TGF-β superfamily, the bone morphogenic proteins (BMP) isoforms 2, 4 and 7. The probable action is to modulate the signalling properties of these factors. CRIM1 has also been shown to regulate the release of VEGFA by podocytes durin
"The Second Mistake" (TSM) is to think that if an act is right or wrong because of its effects, the only relevant effects are the effects of this particular act. This is not (as some think) a truism, since "the effects of this particular act" and "its effects" need not co-refer. Derek Parfit's rejection of TSM is based mainly on intuitions concerning sets of acts that over-determine certain harms.
INTRODUCTION: We have shown that low protein C levels predict poor survival up to five years in a general intensive care unit patient material and hypothesize that treatment with protein C is beneficial. The objectives were to calculate costs of protein C treatment, at best-case scenario, per statistical life saved. MATERIALS AND METHODS: Ninety-two patients with deranged global haemostatic tests
In humans, the non-gastric H+/K+ ATPase (ATP1AL1) has previously been shown to be expressed in the epithelia of skin, kidney and colon. In this study we tested the hypothesis that the non-gastric H+/K+ ATPase is localized to the syncytiotrophoblast, the transporting epithelium of the human placenta. Microvillous (MVM) and basal plasma membranes (BM) of the syncytiotrophoblast were isolated from te
In this paper, we analyse the functioning of private capital markets in Holland in the late medieval period. We argue that in the absence of banks and state agencies involved in the supply of credit, entrepreneurs' access to credit was determined by two interrelated factors. The first was the quality of property rights protection and the extent to which properties could be used as collateral. The
Environmental problems are said to be research dependent, as science is needed to identify phenomena such as climate change. New technological cures are however often characterised by both research dependence and scientific uncertainty. One example is Biofuels. A few years back they were seen as a sustainable solution to the transport sector's carbon dioxide emissions and oil dependence. Since
Persuasive messages are commonly used in campaigns promoting sustainable transport to motivate people to reduce private car use. This paper explores the preconditions affecting the motivation of people to reduce private car use when exposed to such messages. A sample of 1100 Swedish residents was analysed for the effect of variables related to accessibility, usual commute mode and attitudes. Signi
BackgroundA novel non-invasive method for generation of pressure volume loops (PV-loops) using brachial blood pressure and cardiovascular magnetic resonance (CMR) imaging has recently been presented and validated (1). The non-invasive nature of this method enables calculation of PV-loops in large patient cohorts previously not feasible due to the need of invasive measurements.PurposeThe purpose of
Through this study were discussed the main issues regarding consumer compensation of damages which they suffer due to the infringements of the EU competition rules. In the first chapter of the study were discussed the issues of rise of the right to damages, the questions whether consumers as end purchasers have the right to claim damages in the EU, which was answered in the positive. Furthermore,
MERGE (ModElling the Regional and Global Earth system) står för modellering av jordens klimatsystem, med fokus på vegetation och terrestra ekosystem. Målet för den nationella strategiska plattformen är att öka kunskapen om klimatet med speciellt fokus på hur atmosfär, markyta, vegetation och ekosystem samverkar. Verksamheten omfattar avancerad forskning, disciplinär och tvärvetenskaplig forskarutbMERGE is a Strategic Research Area working with modelling the regional and global Climate System with focus on the interactions between the climate and the terrestrial biosphere. MERGE brings together more than 150 researchers collaborating across five Swedish universities - Lund University, Chalmers, University of Gothenburg, KTH and SMHI. The cutting-edge research environment are experts on the
Att studera den ekonomiska utvecklingen i det globala syd ur ett långsiktigt perspektiv blir allt viktigare i en samtid av globalisering, integration och konvergens. Detta har relevans för både det globala nord och de akademiska organisationer i Afrika, Asien och Latinamerika som vuxit fram och håller på att utvecklas.The study of economic development in the Global South from a long-term perspective is of increasing importance in the current era of globalization, integration and convergence. This applies both in the Global North and for the growing academic communities in Africa, Asia and Latin America.
Epidemiologi för hälsa - en gemensam satsning för Lund och Uppsala universitet för nationell och internationell excellensEpidemiology for health - a joint initiative between Lund and Uppsala universities for national and international excellence
Forskningen är huvudsakligen tillämpningsorienterad och inspirerad av idustriella problem.[BR] Projekten utförs i samarbete med svensk industri på områdena elkraftsystem, tillverkningssystem,[BR] urbana vattensystem, elektriska drivsystem och elhybridfordonThe research is application oriented and inspired by industrial problems.[BR] Application areas are electric power systems, urban water systems,[BR] electric drives, power electronics, autonomous manufacturing systems [BR]and electro-hybrid vehicles.
Extracellular signal-regulated kinase 2 (ERK2) is located in the cytoplasm of resting cells and translocates into the nucleus upon extracellular stimuli by active transport of a dimer. Passive transport of an ERK2 monomer through the nuclear pore is also reported to coexist. We attempted to characterize the cytoplasmic retention and nuclear translocation of fusion proteins between deletion and sit
an-European research infrastructures (RIs) have been labelled a ‘pillar’ of the European Research Area initiative and ‘engines’ which are expected to drive forward the European Union (EU) economy by advancing its science and technology and ultimately its competitiveness on the global arena. The focus of this article is on the origins and nature of a policy tool named the European Research Infrastr
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