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Extracellular signal-regulated kinase 2 (ERK2) is located in the cytoplasm of resting cells and translocates into the nucleus upon extracellular stimuli by active transport of a dimer. Passive transport of an ERK2 monomer through the nuclear pore is also reported to coexist. We attempted to characterize the cytoplasmic retention and nuclear translocation of fusion proteins between deletion and sit
an-European research infrastructures (RIs) have been labelled a ‘pillar’ of the European Research Area initiative and ‘engines’ which are expected to drive forward the European Union (EU) economy by advancing its science and technology and ultimately its competitiveness on the global arena. The focus of this article is on the origins and nature of a policy tool named the European Research Infrastr
Forskargruppen studerar gynekologisk cancer och förebyggande av livmoderhalscancer och benskörhet. Självprovtagning från slidan för HPV-analyser och andra diagnostiska metoder såsom metyleringsanalyser visar lovande resultat för att förebygga livmoderhalscancer. Avseende äggstocks- och livmodercancer letar vi efter biomarkörspaneler och DNA-mutationer i blod för diagnostik och att prediktera prognWe study Gynecological cancer and the prevention of cervical cancer and osteoporosis. We evaluate self-sampling HPV analyses and other diagnostic methods such as methylation analyses in cervical cancer prevention. In ovarian and endometrial cancer, we search for biomarker panels and cell free DNA mutations as diagnostic and predictive markers. We study Quality of Life (QoL) and patient related exp
I över femtio år har Teaterhögskolan i Malmö utbildat skådespelare som verkat på svenska och internationella scener, i film, radio och tv. Skolan har ett gediget rykte som en av Nordens ledande teaterutbildningar med ett tydligt metodiskt förhållningssätt, en medveten pedagogisk progression och en konsekvent syn på teaterns kunskapskärna som handlingsbaserad. Teaterhögskolan har funnits på BergsgaFor over fifty years Malmö Theatre Academy has trained professional actors working in theatre, film, radio, and TV nationally and internationally. It has a solid reputation as one of the Nordic region's leading theater educations with a clear methodological approach, a conscious pedagogical progression, and a consistent view of the theater's core knowledge as action based. The academy is located a
Enheten för kognitiv sjukdomsforskning är en translationell forskargrupp med fokus på neurodegenerativa och neuropsykiatriska sjukdomar såsom Alzheimers sjukdom, demens med Lewy-kroppar, Parkinsons sjukdom, frontallobsdemens och depression. Vår forskning är patientnära, vilket möjliggörs då gruppen består av neurobiologer, läkare, statistiker, farmaceuter, sjuksköterskor, fysio- och arbetsterapeutCognitive disorder research unit is a translational research group focusing on neurodegenerative and neuropsychiatric disorders such as Alzheimer’s disease, Dementia with Lewy bodies, Parkinsons disease, Frontal lobe dementia and Major depression. Our approach is strongly patient-oriented, which is strengthen by our wide variety of professional backgrounds including neurobiologists, physicians, st
Huntington’s disease (HD) is caused by CAG repeat expansion in the huntingtin (HTT) gene. Skeletal muscle wasting alongside central pathology is a well-recognized phenomenon seen in patients with HD and HD mouse models. HD muscle atrophy progresses with disease and affects prognosis and quality of life. Satellite cells, progenitors of mature skeletal muscle fibers, are essential for proliferation,
The circulation is a closed system that has been assumed to be free from bacteria, but evidence for the existence of a low-density blood microbiota is accumulating. The present study aimed to map the blood microbiota of outpatients with Crohn’s disease (CD) or with ulcerative colitis (UC) by 16S metagenomics. A diverse microbiota was observed in the blood samples. Regardless of the type of disease
Companies enjoy increasingly extensive protection of their fundamental right to conduct business under EU law. This article will examine whether this protection is justified by reference to the foundational value of human freedom. In other words, does the way in which EU law protects the fundamental rights of companies to conduct business promote the freedom of individuals human beings within the
B-cell leukemia 3 (Bcl-3) is a member of the inhibitor of κB family, which regulates a wide range of biological processes by functioning as a transcriptional activator or as a repressor of target genes. As high levels of Bcl-3 expression and activation have been detected in different types of human cancer, Bcl-3 has been labeled a proto-oncogene. Our study uncovered a markedly upregulated Bcl-3 ex
This paper provides the first regional econometric decomposition of CO2 emissions from fuel combustion in eight regions of the world. Using the best publically-available time series data (1971–2011), the analysis examines the key determinants and relationships of the ‘Green Energy Economy’ (GEE) in Africa, Asia, Latin America and the Caribbean, the Middle East, Non-OECD Europe and countries from t
The high-risk Alpha-types of human papillomavirus (HPV) are the causative agent of cervical cancer, which is the second major cause of death among women worldwide. Recent investigations have shown that E7 from the Alpha-papillomavirus HPV-16 interacts with IKK alpha and IKK beta of the IKK complex in the NF-kappa B pathway leading to an attenuation of the activity. There is a possible link between
In skin, hemidesmosomal protein complexes attach the epidermis to the dermis and are critical for stable connection of the basal epithelial cell cytoskeleton with the basement membrane (BM). In muscle, a similar supramolecular aggregate, the dystrophin glycoprotein complex links the inside of muscle cells with the BM. A component of the muscle complex, dystroglycan (DG), also occurs in epithelia.
The Bacillus subtilis hemAXCDBL operon encodes enzymes for the synthesis of 5-aminolaevulinic acid via the C5 pathway (hemA and hemL) and uroporphyrinogen III (hemB, hemC and hemD). B. subtilis HemA protein (molecular mass 50 kDa) was overexpressed in hemA mutants of both Escherichia coli and B. subtilis. A mutant B. subtilis HemA protein with a Cys to Tyr change at position 105 was also overexpre
Warming in the Arctic accelerates thawing of permafrost-affected soils, which leads to a release of greenhouse gases to the atmosphere. We do not know whether permafrost thaw also releases non-methane volatile organic compounds that can contribute to both negative and positive radiative forcing on climate. Here we show using proton transfer reaction–time of flight–mass spectrometry that substantia
The diving response reduces the pulmonary O(2) uptake in exercising humans, but it has been debated whether this effect is present at rest. Therefore, respiratory and cardiovascular responses were recorded in 16 resting subjects, performing apnea in air and apnea with face immersion in cold water (10 degrees C). Duration of apneas were predetermined to be identical in both conditions (average: 145
Extracellular matrix, either produced by cancer cells or by cancer-associated fibroblasts, influences angiogenesis, invasion and metastasis. Chondroitin/dermatan sulfate (CS/DS) proteoglycans, which occur both in the matrix and at the cell surface, play important roles in these processes. The unique feature that distinguishes DS from CS is the presence of iduronic acid (IdoA) in DS. Here, we repor
Serglycin is a proteoglycan expressed by some malignant cells. It promotes metastasis and protects some tumor cells from complement system attack. In the present study, we show for the first time the in situ expression of serglycin by breast cancer cells by immunohistochemistry in patients' material. Moreover, we demonstrate high expression and constitutive secretion of serglycin in the aggressive
Objective. Lipid embolizations from retransfused shed blood during cardiac surgery have been shown to enter the circulation and end up in different organs. The purpose of this investigation was to evaluate differences in the kinetics and deposition between emulsified and non-emulsified lipid emboli in a porcine model. Design. Twelve animals were anesthetized and put on cardiopulmonary bypass. A sh
