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Levodopa-induced dyskinesia (LID) is a debilitating complication of symptomatic therapy in Parkinson's disease. Although there is compelling evidence that striatal pathophysiology is a major driver of LID, the specific circuit mechanisms governing its expression remain obscure. To address this gap, molecular, cellular, and behavioral strategies were used to interrogate circuits in a mouse model of
H-kininogen (high-molecular-mass kininogen, HK) is the precursor of the vasoactive peptide hormone bradykinin (BK). Previous work has demonstrated that HK binds to Streptococcus pyogenes through M-proteins, fibrous surface proteins and important virulence factors of these bacteria. Here we find that M-protein-expressing bacteria absorb HK from human plasma. The HK bound to the bacteria was found t
Ribosomes are the protein synthesizing factories of the cell, polymerizing polypeptide chains from their constituent amino acids. However, distinct combinations of amino acids, such as polyproline stretches, cannot be efficiently polymerized by ribosomes, leading to translational stalling. The stalled ribosomes are rescued by the translational elongation factor P (EF-P), which by stimulating pepti
The relationship between the receptors for the Epstein-Barr virus (EBV) and the C3d fragment of complement was investigated at the molecular level. In the presence of cell-bound C3, virus binding was enhanced in EBV genome-carrying lines. An identical effect could be elicited by C3d at one-quarter the weight amount; C3b and methylamine-treated C3 had no effect on virus binding. The minimum concent
blodfetter – Vetenskap och Hälsa Hoppa till innehåll Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Etikett: blodfetter Går det att äta sig till ett friskare blod? 2020-06-16 VI UPPMÄRKSAMMAR INTERNATIONELLA BLODGIVARDAGEN 14 JUNI För att vi ska må bra behöver kroppens blodflöde fungera och ge syre och näring
https://www.vetenskaphalsa.se/tag/blodfetter/ - 2026-07-23
In mudflats, interactions and transfers of nutrients and secondary metabolites may drive ecosystems and biodiversity. Foraminifera have complex trophic strategies as they often rely on bacteria and eukaryotes or on potential symbionts for carbon and nitrogen resources. The capacity of these protists to use a wide range of adaptive mechanisms requires clarifying the relationships between them and t
In Armenia, women are systematically excluded from political processes and issues related to gender equality and women’s rights are not politically prioritized. In the absence of this prioritization, civil society actors play a vital role in promoting and addressing issues related to women. Inclusion is often promoted as a key element in democratization processes and this study takes a gender pers
The aim of the study has been to investigate how discriminatory factors interlink and are conceptualized in governmental policies and strategies, within the field of gender equality and anti-racism work in Sweden. The Study used WPR approach developed by Bacchi as the method of policy analysis, a theoretical lens of intersectionality has been used to understand who the documents are representing i
Thymus colonisation and thymocyte positioning are regulated by interactions between CCR7 and CCR9, and their respective ligands, CCL19/CCL21 and CCL25. The ligands of CCR7 and CCR9 also interact with the atypical receptor CCRL1 (also known as ACKR4), which is expressed in the thymus and has recently been reported to play an important role in normal alpha beta T-cell development. Here, we show that
amning – Vetenskap och Hälsa Hoppa till innehåll Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Etikett: amning ”Mer stöd till brösten” 2026-06-01 De flesta kvinnor uppger under sin graviditet att de gärna vill amma och att de ser hälsofördelar både för sitt barn och för sig själva. Ändå är det bara cirka 60 p
https://www.vetenskaphalsa.se/tag/amning/ - 2026-07-23
The International Society for Clinical Densitometry (ISCD) has published position statements on topics relating to the use and interpretation of measurements of bone mineral density (BMD). The most recent appeared in the Journal of Clinical Densitometry (1) and was republished in the Journal of Endocrinology and Metabolism and in Osteoporosis International (2,3). The topics included the indication
