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The aim of this study was to verify the advanced inhomogeneous dose distribution produced by a volumetric arc therapy technique (RapidArc) using 3D gel measurements and Monte Carlo (MC) simulations. The TPS (treatment planning system)-calculated dose distribution was compared with gel measurements and MC simulations, thus investigating any discrepancy between the planned dose delivery and the actu
Viral vector-mediated gene transfer utilizing adeno-associated viral vectors has recently entered clinical testing as a novel tool for delivery of therapeutic agents to the brain. Clinical trials in Parkinson's disease using adeno-associated viral vector-based gene therapy have shown the safety of the approach. Further efforts in this area will show if gene-based approaches can rival the therapeut
Parents re-emerged sooner at higher densities but the total proportion that re-emerged was independent of density. Over 20 offspring per female were produced at the lowest density (0.5/100 cm2) but only 0.6 per female at the highest density (31/100 cm2). Offspring from the lowest density were about 50% heavier than those from the highest density and also the fat content increased with decreasing d
We present multiband photometry covering ∼5° × 5° across ω Cen collected with the Dark Energy Camera on the 4 m Blanco telescope, combined with Hubble Space Telescope and Wide Field Imager data for the central regions. The unprecedented photometric accuracy and field coverage allows us to confirm the different spatial distribution of blue and red main-sequence stars, and of red giant branch (RGB)
Objectives: To assess the existence of international, scientifically validated methods for manual surgical skills training and assessment. The aim was to create a descriptive chronological summary of the existing evidence and conclusions in the included articles. Methods: PubMed and Scopus were searched twice for reviews published between 1997 and October 2023 and between 1997 and January 2024. Th
Aims Aortic valve calcification (AVC) is an underlying pathophysiological mechanism for aortic stenosis that is common in the elderly, but less is known in younger individuals. The aim was to study the prevalence and associated characteristics of AVC in a middle-aged general population. Methods and results Data were obtained from the Swedish CArdioPulmonary bioImage Study (SCAPIS) comprising 30 15
PurposeThe paper aims to examine some economical, political and health system indicators on the transmission of the COVID-19 transmission within the national system. The main objective is to investigate what are the most effective indicators which have led to the declared numbers by countries.Design/methodology/approachThis study combined multiple sets of data to describe best the economical statu
Background: Doppler ultrasound can diagnose testicular torsion with high sensitivity and specificity but may delay surgical treatment. This study aims to assess whether the use of doppler ultrasound, in cases with intermediate clinical suspicion of testicular torsion, can improve diagnostic accuracy compared to clinical assessment alone. Methods: We implemented a new clinical algorithm where patie
BACKGROUND: Physical activity (PA) has health benefits for people with type 2 diabetes (T2D). Indeed, regular PA is considered an important part of any T2D management plan, yet most patients adopt a sedentary lifestyle. Exercise referral schemes (ERS) have the potential to effectively promote physical activity among T2D patients, and their effectiveness may be enhanced when they are supported by c
With the vast amount of data available, and its increasing complexity in manufacturing processes, traditional statistical approaches have started to fall short. This is where machine learning plays a key role, addressing the challenges by bringing the ability to analyse large and complex datasets from multiple sources, finding non-linear and intricate patterns on data, relationships between severa
In today's competitive society the difference between winning and disappearing might very well be dependent on who is first to release a new product or an update to an existing product to the market. The impact that this situation has on the design analysis department in a company is tremendous. It is a known fact, to everyone working with design analysis, that the demands on analyses from the pro
Background Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013), we estimated these quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013. Methods Estimate
Introduction: Soft tissue knee injury is a well-established and potent risk factor for development of knee osteoarthritis. However, there is a paucity of epidemiological data from the general population. Our aim was to estimate the annual person-level incidence for a wide spectrum of clinically diagnosed soft tissue knee injuries, and their distribution by age, sex, and season. Methods: In Sweden,
Compassion fatigue (CF), a diminished empathic capacity resulting from prolonged exposure to others’ distress, is an emerging concern in the teaching profession. This study investigates the prevalence and predictors of CF among Swedish teachers, with a particular focus on reduced compassion toward students. Drawing on the job demands-resources model and the compassion fatigue resilience model, we
The genus Mentha is highly valued in pharmaceutical, culinary, and personal care industries due to its rich aromatic and pharmacological traits. However, its complex taxonomy and genetic diversity create challenges for breeding programs focused on aroma and therapeutic qualities. To address these challenges, this study developedand validated a rapid, semi-quantitative metabotyping method to efficiThe genus Mentha is highly valued in pharmaceutical, culinary, and personal care industries due to its rich aromatic and pharmacological traits. However, its complex taxonomy and genetic diversity create challenges for breeding programs focused on aroma and therapeutic qualities. To address these challenges, this study developedand validated a rapid, semi-quantitative metabotyping method to effici
Rebecca Yarros’s Fourth Wing (2023) is a romantasy novel with a complex dragon society where dragons’ personalities, tempers and looks vary and affect each other. It is a new work of fiction, the first book in her still unfinished Empyrean series, and thus not many have had the chance to explore and discuss it in a formal capacity. The previous discussion is mainly made up of book reviews, and the
