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The exocrine pancreas is mainly regulated via neuro-hormonal pathways. CCK-dependent regulatory pathways and CCK-receptor subtype involved seem to differ between mammalian species. The first aim of the thesis was to establish the physiological dose-range for CCK, to further explore the short entero-pancreatic reflex and CCK-receptor subtypes involved in the CCK-mediated regulation of the exocrin
This paper describes the results of a perception experiment in which subjects listening to a retold story in Dutch were asked to mark various perceived discourse structures and to give their judgements on prominence in the verbatim transcription of that story. They marked discourse boundaries by means of conventional punctuation, indicating perceived non-final, sentence final, and paragraph final
Drug therapy is often directed to specific organ and tissue compartments where the mode of action of the compound effects specifically targeted biological processes. However, the direct measurement of drug uptake in terms of a time kinetic and concentrations attained at the local sites has not been readily available as a clinical index for most drugs. A proof-of-principle study was conducted to te
BACKGROUND: Healthcare today is a complex system with increasing needs of specific knowledge of evaluation of research and implementation into clinical practice. A critical issue is that we all apply evidence-based practice (EBP) with standardised methods and continuing and systematic improvements. EBP includes both scientific and critical assessed experience-based knowledge. For the individual,
The dominating local and regional sources of gaseous and particulate air pollution in the city of Lund (69,000 inhabitants) in southern Sweden were characterized using a combination of aerosol and gas-phase monitoring techniques. Twelve-hour samples were taken at two stations of both fine and coarse fraction urban aerosols with a stacked filter unit during the four-week measurement campaign in Mar
BACKGROUND: To elucidate the mechanism by which local delivery of 3-morpholino-sydnonimine (SIN-1) affects intimal hyperplasia after percutaneous transluminal coronary angioplasty (PTCA). METHODS: Porcine coronary arteries were treated with PTCA and immediately afterwards locally treated for 5 minutes, with a selective cytosolic guanylate cyclase inhibitor, 1 H-(1,2,4)oxadiazole(4,3-alpha)quinox
Amphibians are declining worldwide, but lack of long-term regional data makes identifying possible causes difficult, hindering conservation efforts. We evaluated whether habitat destruction, terrestrial habitat adjacent to ponds and the physico-chemical characteristics of ponds could explain the regional and local decline of the spadefoot toad (Pelobates fuscus) in Sweden. Analyses of aerial photo
We investigated whether local biotic and abiotic conditions could explain the occurrence of calling males of the declining spadefoot toad Pelobates fuscus in 72 ponds in southern Sweden. The ponds covered the entire distribution range of P. fuscus and were monitored during the breeding season in 2000. Calling males were found in 33 ponds. representing ca 50% of all known ponds for the species ill
Cardiovascular diseases are accountable for almost 50 % of the mortality number in Europe which is why research on its causes is highly prioritised. For practical and ethical reasons, in vitro study models are of high importance to enable research on cardiac abnormal behaviours. To meet this issue, researchers from Imec, Belgium, developed Neuray-II, the second generation of a biocompatible chip w
Illegal timber harvest and trade is one of the main challenges in the context of global deforestation and sustainability. Different governance and self-governance initiatives throughout the history with the aim to regulate global forest commons have received plenty of criticism. This research investigates the potential of genetic timber tracking technologies as a tool to enhance existing systems a
Capsaicin is used to investigate the role of peripheral sensory nerve fibers. In previous studies of rats treated by injection of capsaicin into the skin of the neck, 'spontaneous' lesions in the head and neck region were observed. In this study, the course of development over time, the regional distribution and the innervation of capsaicin-induced dermal lesions were assessed in young male Spragu
Agricultural management and vegetation complexity affect arthropod diversity and may alter trophic interactions between predators and their prey. Web-building spiders are abundant generalist predators and important natural enemies of pests. We analyzed how management intensity (tillage, cutting of the vegetation, grazing by cattle, and synthetic and organic inputs) and vegetation complexity (plant
Acute Pancreatitis (AP) is an inflammation disease that characterized by activation of protease and the innate immune system, leading to infiltration of neutrophils and tissue damage in the pancreas. The aim of this thesis was to determine the role of isoprenylation (farnesyltransferase and geranylgeranyltransferase) as well as NET formation in regulating recruitment of neutrophils and tissue dama
Popular Abstract in Swedish Energibalansen vid jordytan är av avgörande betydelse för Jordens alla ekosystem men när det gäller Arktiska och sub-Arktiska ekosystem är kunskapen bristfällig. I dynamiska system som klimatsystemet, påverkas utbytet av energi, vatten och växthusgaser av små förändringar i ekosystemen. Syftet med denna avhandling är därför att skapa ökad kunskap och en tydligare bild aThe surface energy balance determines the functioning of any ecosystem on the Earth but is still poorly understood in Arctic and subarctic biomes. In a dynamic system, such as the Earth’s climate, any change in its characteristics modifies the exchange of energy, water, and greenhouse gases between the surface and the atmosphere. Therefore, this thesis aims to draw a conclusive picture of the surf
Popular Abstract in Swedish Urinvägsinfektioner (UVI) är en av människans vanligaste bakteriella infektioner och drabbar både kvinnor och män. Kvinnor drabbas av UVI under hela sitt vuxna liv, medan UVI incidensen hos män ökar efter 40 – 50 års ålder pga. ökande problematik i urinvägarna med prostataförstoring, m.m. UVI orsakas av ett flertal olika bakteriearter, men tarmbakterien Escherichia coliUrinary tract infections (UTI) are among the most common human infections, and febrile UTI with bacteremia the most severe form. The relation between bacteria and host decides disease severity. The dominating uropathogen is Escherichia coli (E. coli). P fimbriae are the virulence factor of E. coli most clearly associated to severe disease. P fimbriated E. coli predominated in bacteremic febrile UT
The overall aim of this work is to study and interpret how social relations were expressed, shaped, and changed in the Late Middle Neolithic. The empirical foundation is a study of settlement in the Malmö area, south-west Skåne, Sweden. Other parts of southernmost Sweden (and eastern Denmark) are also concerned. Sites are discussed and given an overall interpretation as regards chronological and c
This work is theoretical analyses of heat transfer across film a flowing over the surface of a rotating disk. This field has wide industrial applications in Turbomachinery, chemical, and food industries. An analytical study is developed to investigate the heat transfer characteristics in the liquid film due to jet impinging at the center of the disk. A theoretical model is based on heat balance an
Avian communities play a pivotal role in Arctic ecosystems and birds have become the key model taxa for climate change research. Due to funding priorities, Arctic passerines have been studied less intensively than waterfowl and shorebirds. In our study, we aim to partly fill this gap and look at the change in passerine community species composition in the Chaun River Delta in Northeast Siberia (68
Farmers as volunteers in research could potentially provide a rich resource for exploring sustainable agricultural research questions. To discern emerging patterns in citizen science-based studies on topics with relevance for sustainable agriculture, and reveal salient challenges and opportunities for conducting such studies, we conducted a systematic literature review of 27 peer-reviewed articles
Elastic turbulence has emerged as a promising method to enhance heat transfer performance at the microscale. However, previous studies have mainly focused on the overall convective heat transfer performance in curved channels, overlooking the fact that the chaotic flow intensity varies along the streamline, leading to diverse local heat transfer characteristics. In this study, we systematically in
