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Background: Accurate diagnosis and staging are essential for optimal treatment planning of prostate cancer. By combining functional and anatomical imaging, PSMA-PET/mpMRI offers a potential to improve lesion detection and enhance staging accuracy. This study aimed to evaluate the diagnostic performance of lesion detection and local staging of prostate cancer using combined PSMA-PET/mpMRI compared
Background and Goal of StudyWe aimed to develop, implement and evaluate a mobile system using off-the-shelf components, torecord and review simulations and debriefings in four separate rooms during standardized simulation courses at multiple centres in Sweden. Ourrequirements were: high quality sound and video; easy to install, use and demount; suitable for transport by courier; no requirement to
BACKGROUND: Analyses of clinical outcomes following radiotherapy (RT) have advanced our understanding of fundamental radiobiological characteristics in head and neck squamous cell carcinoma (HNSCC). Low fractionation sensitivity appears to be a common feature, as well as susceptibility to changes in overall treatment time (OTT). Large tumors should be harder to cure if a successful RT requires the
Background: Herbivores modify the structure and function of tundra ecosystems. Understanding their impacts is necessary to assess the responses of these ecosystems to ongoing environmental changes. However, the effects of herbivores on plants and ecosystem structure and function vary across the Arctic. Strong spatial variation in herbivore effects implies that the results of individual studies on
BACKGROUND: Blood-based biomarkers are a promising tool for early detection of Alzheimer's disease (AD). We recently showed that individuals with autosomal-dominant AD due to the E280A mutation in the presenilin1 gene (PSEN1) showed elevated levels of plasma tau phosphorylated at threonine 217 (P-tau217) and neurofilament light chain (NfL), as early as approximately 20 years before clinical onset.
Radioresistance, the failure to achieve a desired outcome, is an obstacle in clinical radiotherapy. In this thesis we investigate factors affecting radioresistance and strategies to overcome it, both with established clinical approaches and by using novel pre-clinical discoveries. Study I & II concern the impact of tumour volume in patients with oropharyngeal cancer. In a large, pooled cohort
Barnahus syftar till att förbättra utredningar och samarbete mellan myndigheter när barn misstänks ha varit utsatta för brott som misshandel eller sexuella övergrepp. I Barnahus samverkar olika instanser som socialtjänst, polis, åklagare, barnmedicin, rättsmedicin samt barn- och ungdomspsykiatri i en barnvänlig miljö. I stället för att behöva upprepa sin berättelse för olika tjänstemän på olika plBarnahus in Sweden exist to improve investigations and the collaboration between public agencies when children are suspected being victims of physical and/or sexual abuse. Barnahus are multi-agency collaborations that bring together local authority child welfare services, the police, public prosecutors, paediatric medicine, forensic medicine, and child- and adolescent psychiatry in a child-friendl
BACKGROUND: HLA-DR4, a common antigen of HLA-DRB1, has multiple subtypes that are strongly associated with risk of type 1 diabetes (T1D); however, some are risk neutral or resistant. The pathobiological mechanism of HLA-DR4 subtypes remains to be elucidated.METHODS: We used a population-based case-control study of T1D (962 patients and 636 controls) to decipher genetic associations of HLA-DR4 subt
Background: To understand how the neuronal circuits in the brain process information there is a need for novelneuro-electronic interfaces that can interact chronically with brain tissue with minimal disturbance of thephysiological conditions in the tissue, in awake and freely moving animals. For this, there is a need for implantableneuro-electronic interfaces that are mechanically compliant with t
Background: Infection and graft-versus-host disease (GvHD) are the major causes for mortality and morbidity of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Plasma-derived extracellular vesicles (EVs) contain disease-related proteins, DNAs and RNAs, and have recently been suggested as potential biomarker candidates for transplantation complications. However, EV isolation from sma
Mercury (Hg) is known to induce adverse immune reactions in sensitive individuals. e.g. selected inbred animal strains. Such reactions involve oral tissues and may reflect immune phenomena, that may also occur in some human oral diseases. Administration of low doses of HgCl2 to the genetically Hg-sensitive BN rats results in the development of a syndrome with autoimmune features [BN(Hg
1. The mechanisms driving nonrandom assembly patterns in plant communities have long been of interest in ecological research. Competing ecological theories predict that coexisting species may either be more functionally dissimilar than expected by chance (with functional divergence' mainly reflecting niche differentiation) or be functionally more similar than expected (with functional convergence'
Agricultural intensification has led to dramatic population declines among many farmland bird species. Negative effects of intensive farming in terms of decreased local habitat quality or structural simplification of farmland landscapes have reduced both reproductive outcome and winter survival of many species. Studies investigating agricultural effects on migrating birds using farmland as stopove
In the work presented in the thesis laser diagnostics was employed primarily in the investigation of engines, but was also used to study soot in flames. Quantitative measurements were performed for visualizing both in-cylinder soot formation and DME sprays in a combustion vessel. The DME sprays inside a diesel truck engine were also qualitatively investigated. The combustion process in the HCCI en
This study sets out to contribute to the research of entrepreneurial motivations of craft entrepreneurs from a lifestyle perspective. It contributes to the research fields of both crafting and lifestyle. In addition the purpose of this thesis is to attempt to provide valuable information to the research field and uncover data for future research. The geographical location of the research is the so
Consumerism contributes to sustainability problems of social fragmentation and environmental degradation. In response to this the sharing economy is a relatively new and rapidly growing phenomenon. While the for-profit sharing economy has received considerable academic attention and critique, there is a lack of research that explores the alternative: the non-profit sharing economy. This paper addr
Nordic Waterproofing is one of the largest roofing felt producers in Europe. One of the production facility is located in Höganäs (Sweden), which is specialized in roofing felt that are suitable for the nordic climate. Bitumen is a central component of roofing felt manufacturing that contribute several properties to the product. Due to the importance of bitumen, Nordic Waterproofing finds an addit
Popular Abstract in Swedish Oönskade reaktioner efter vaccination och allergenspecifik immunoterapi - Kontaktallergi för aluminium och kliande knutor För att ett vaccinationsprogram ska fungera krävs kontinuerlig uppföljning av vaccinernas säkerhet vad gäller eventuella oönskade reaktioner. Under de senaste 10 till 15 åren har en ökad oro noterats bland allmänhet och profession beträffande oönskadThe aim of the work presented in this thesis was to investigate two different types of adverse reactions, persistent itching nodules and contact allergy to aluminium, after immunization with aluminium-containing vaccines and aluminium-containing allergen extracts used for allergen-specific immunotherapy (ASIT). The first paper describes active parental reporting of adverse events (AEFIs) after a
Most fractures heal uneventfully but some evolve into nonunions. Autologous bone graft is the gold standard for stimulating healing. However, donor site morbidity, and limited graft supply make alternatives interesting. Bone Morphogenetic Proteins, BMPs, are growth factors involved in bone signaling. They are available in recombinant form for local application in nonunions and stimulate differenti
The overall aim of this thesis was to provide a representative estimate of the potential impacts of climate change and increased atmospheric CO2 concentrations on Swedish forest ecosystems and the key ecosystem services they provide. In order to achieve this task, fi rst LPJ-GUESS, a process-based regional ecosystem modelling framework, was applied to explore how possible shifts in climatic zones
