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Targeting the androgen receptor (AR) pathway prolongs survival in patients with prostate cancer, but resistance rapidly develops. Understanding this resistance is confounded by a lack of noninvasive means to assess AR activity in vivo. We report intracellular accumulation of a secreted antigen-targeted antibody (SATA) that can be used to characterize disease, guide therapy, and monitor response. A
The purpose was to investigate whether signs of DMTm (Defense Mechanism Technique modified) could discriminate between the ten groups of DSM-III-R personality disorders (PDs) and DSM-III-R clusters among drug abusers. DMTm signs are interpreted as different kinds of defense and anxiety. The 65 subjects were recruited from Sabbatsberg Hospital, Sweden. Prominent affect defenses were projected intro
The recent “Conscious Turing Machine” (CTM) proposal offered by Manuel and Lenore Blum aims to define and explore consciousness, contribute to the solution of the hard problem, and demonstrate the value of theoretical computer science with respect to the study of consciousness. Surprisingly, given the ambitiousness and novelty of the proposal (and the prominence of its creators), CTM has received
Work in developmental pragmatics has shown that even though infants display refined mindreading abilities, older children struggle to understand language phenomena that rely on mindreading. This apparent mismatch might be partially explained by considering children's growing sensitivity to social categories such as their interlocutor's age. Based on recent work in philosophy of mind, we investigat
Popular Abstract in Swedish Denna avhandling syftar till att förbättra styrningen av myoelektriska handproteser. De primära målen har varit (1) att generera korrekt kontroll för så många handrörelser som möjligt, (2) att förbättra träningsförfarandet så att operatören på ett intuitivt sätt snabbt kan bemästra ett flertal rörelser och (3) att minska tiden som behövs för att matematiskt justera in sAn investigation of improvements of myoelectric prostheses has been undertaken. The primary aims of this thesis were (1) to generate an accurate prediction of as many hand movement as possible, (2) to produce a training setup for subjects allowing intuitive and instant control over multiple movements, and (3) to reduce the training cycle for the control system to a maximum of a couple of minutes t
Microsoft Word - Program_ClimBEco summer meeting 2024 The nature of the urban: sustainability challenges in the city ClimBEco summer meeting 2024 25-27 September @ Clarion Grand Hotel & the innovation center Parken, Helsingborg www.climbeco.lu.se The purpose of this thematic meeting is to gain a deeper understanding of sustainability challenges in urban spaces. We will consider developed and devel
https://www.mgeo.lu.se/en/sites/mgeo.lu.se.en/files/2026-06/Program%20ClimBEco%20autumn%20meeting%202024_0.pdf - 2026-06-30
Revised simulation theory (Goldman, 2006) allows mental state attributions containing some or all of the attributor’s genuine, non-simulated mental states. It is thought that this gives the revised theory an empirical advantage, because unlike theory theory and rationality theory, it can explain egocentric bias (the tendency to over attribute ones’ own mental states to others). I challenge this vi
While foreign direct investments (FDI) are promoted as a vehicle for economic development their environmental consequences are less estab-lished. This study tests the hypotheses that 1) FDI led to environmental deg-radation in form of increased greenhouse gas emissions during Sub-Saharan Africa´s recent growth spurt but that 2) this impact was felt to a lesser extent in countries with a higher qua
While foreign direct investments (FDI) are promoted as a vehicle for economic development their environmental consequences are less established. This study tests the hypotheses that 1) FDI led to environmental degradation in form of increased greenhouse gas emissions during Sub-Saharan Africa´s recent growth spurt but that 2) this impact was felt to a lesser extent in countries with a higher quali
Aim: Grass-yellow butterflies (Eurema) are a group of pantropical Pieridae distributed throughout Asia, Australasia, Africa and the New World. However, little is known about their diversification, including the biogeographic mechanism(s) explaining their circumglobal distribution. We present the first densely sampled, time-calibrated phylogeny and biogeographic reconstruction of grass-yellows to c
Peirce's best idea, and the one least implemented by himself and his followers, is that of an ethics of terminology. Using this ethics as a tool, we suggest that many Peircean terms are in fact misleading, or, as he said himself at the end of his life, "injurious."From the point of view of cognitive semiotics, there is no reason to abide by Peirce's definition of semiosis, but, taking up the two q
In a previous study we presented data indicating that the expanded population of CD4(-)CD8(-) (DN) alphabeta T cells in TCRalpha-chain-transgenic mice was partially if not entirely derived from gammadelta T cell lineage cells. The development of both gammadelta T cells and DN alphabeta T cells is poorly understood; therefore, we thought it would be important to identify the immediate precursors of
