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Cancer of unknown primary (CUP) is diagnosed at a metastatic stage, conferring an unfavorable prognosis. The natural history of the disease is poorly understood, which complicates diagnosis, treatment and follow-up. Population-based survival data are lacking regarding location and histology of metastases. From the Swedish Cancer Registry, 18 911 CUP patients were identified between years 1987 and
Visible Multifilter Rotating Shadowband Radiometer (vis-MFRSR) data were collected at Storm Peak Laboratory (SPL), a mountain-top facility in northwest Colorado, from 1999 to 2011 and in 2013. From 2011 to 2014, in situ measurements of aerosol light scattering were also obtained. Using these data sets together, the seasonal impact of dust and biomass burning is considered for the western USA. Anal
A fluvial sequence near Cave Stream (north of Castle Hill Village, central Canterbury), New Zealand, contains organically-preserved plant macrofossils (cuticles). The almost ubiquitous presence of Araucariaceae macrofossils in the lower part of the section and their stratigraphic disappearance roughly coincident with the appearance of the angiosperm leaf Dryandra comptoniaefolia and conifer taxa o
The radial transport, or drift, of dust has taken a critical role in giant planet formation theory. However, it has been challenging to identify dust drift pileups in the hard-to-observe inner disk. We find that the IM Lup disk shows evidence that it has been shaped by an episode of dust drift. Using radiative transfer and dust dynamical modeling we study the radial and vertical dust distribution.
The transient electromagnetic (TEM) method is widely used in resistivity mapping but rarely applied in monitoring experiments. In this study, we present an algorithm to invert time-lapse TEM data, with inversion of both synthetic data and field data. Three main novelties distinguish this new inversion algorithm: i) a multiple-mesh approach is used for the definition of model parameters and forward
In 230 consecutive patients 244 hips were operated with a 32-mm cemented prosthesis. The mean age at surgery was 77 (46-96) years. At the 10-year follow-up 89 patients (95 hips) were dead and 33 patients (35 hips) did not attend because of old age or medical problems. Thirteen hips had been revised for aseptic loosening, two for infection, one for recurrent dislocations, and one for fracture. Four
La conferencia plantea la necesidad de un tránsito hacia otras formasde aplicar la semiótica en el diseño.La semiótica del diseño con enfoque agentivo ofrece elementos paraconocer en detalle la experiencia humana y las condiciones que determinanla construcción de sentido que emerge cuando un usuario integra artefactosa dicha experiencia para el cumplimiento de sus objetivos.El asumir un enfoque se
