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Ytan av alla celler är dekorerad med kolhydrater som står för mycket av den information en cell överför till omgivande celler. Många av kolhydraterna tillhör en föreningsklass som kallas proteoglykaner som består av ett protein sammanbundet med en eller flera långa kolhydratkedjor. Dessa kolhydratkedjor kallas glykosaminoglykaner och är bundna till proteinet via kolhydraten xylos. Än så länge har β-1,4-Galactosyltransferase 7 (β4GalT7) is a key enzyme in the biosynthesis of proteoglycans (PGs) and glycosaminoglycan (GAG) chains, which are important macromolecules involved in many biological processes such as cell growth and cell signaling as well as in cancer pathobiology and viral and bacterial infections. Despite its pivotal role, much is still unknown regarding the specific structure of

The sex pheromones produced by virgin females of three species of small ermine moths occurring sympatrically on the European spindle tree were analysed by gas chromatography and the synthetic compounds tested against male moths in the laboratory and field. Pheromone gland extracts of Yponomeuta cagnagellus were shown to contain tetradecyl acetate, (E)‐11‐ and (Z)‐11‐tetradecenyl acetate, tetradeca

Cancer of unknown primary (CUP) is diagnosed at a metastatic stage, conferring an unfavorable prognosis. The natural history of the disease is poorly understood, which complicates diagnosis, treatment and follow-up. Population-based survival data are lacking regarding location and histology of metastases. From the Swedish Cancer Registry, 18 911 CUP patients were identified between years 1987 and

Visible Multifilter Rotating Shadowband Radiometer (vis-MFRSR) data were collected at Storm Peak Laboratory (SPL), a mountain-top facility in northwest Colorado, from 1999 to 2011 and in 2013. From 2011 to 2014, in situ measurements of aerosol light scattering were also obtained. Using these data sets together, the seasonal impact of dust and biomass burning is considered for the western USA. Anal

A fluvial sequence near Cave Stream (north of Castle Hill Village, central Canterbury), New Zealand, contains organically-preserved plant macrofossils (cuticles). The almost ubiquitous presence of Araucariaceae macrofossils in the lower part of the section and their stratigraphic disappearance roughly coincident with the appearance of the angiosperm leaf Dryandra comptoniaefolia and conifer taxa o

The radial transport, or drift, of dust has taken a critical role in giant planet formation theory. However, it has been challenging to identify dust drift pileups in the hard-to-observe inner disk. We find that the IM Lup disk shows evidence that it has been shaped by an episode of dust drift. Using radiative transfer and dust dynamical modeling we study the radial and vertical dust distribution.

The transient electromagnetic (TEM) method is widely used in resistivity mapping but rarely applied in monitoring experiments. In this study, we present an algorithm to invert time-lapse TEM data, with inversion of both synthetic data and field data. Three main novelties distinguish this new inversion algorithm: i) a multiple-mesh approach is used for the definition of model parameters and forward

In 230 consecutive patients 244 hips were operated with a 32-mm cemented prosthesis. The mean age at surgery was 77 (46-96) years. At the 10-year follow-up 89 patients (95 hips) were dead and 33 patients (35 hips) did not attend because of old age or medical problems. Thirteen hips had been revised for aseptic loosening, two for infection, one for recurrent dislocations, and one for fracture. Four

La conferencia plantea la necesidad de un tránsito hacia otras formasde aplicar la semiótica en el diseño.La semiótica del diseño con enfoque agentivo ofrece elementos paraconocer en detalle la experiencia humana y las condiciones que determinanla construcción de sentido que emerge cuando un usuario integra artefactosa dicha experiencia para el cumplimiento de sus objetivos.El asumir un enfoque se