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In this paper we consider a 1-warehouse, N-retailer inventory system where demand occurs at all locations. We introduce an inventory model which allows us to set different service levels for retailers and direct customer demand at the warehouse. For each retailer a critical level is defined, such that a retailer replenishment order is delivered from warehouse stock if and only if the stock level e

Ferric and copper hexacyanoferrates (PB and CuHCF, respectively) were electrodeposited on glassy carbon electrodes providing a suitable catalytic surface for the amperometric detection of hydrogen peroxide. Additionally glucose oxidase was immobilized on top of these electrodes to form glucose biosensors. The biosensors were made by casting glucose oxidase-Nafion layers onto the surface of the mod

The two isoforms of glutamic acid decarboxylase (GAD), GAD67 and GAD65, synthesize the neurotransmitter γ-aminobutyric acid in neurons and pancreatic β-cells. Previous studies suggest that GAD67 is a soluble cytosolic protein, whereas GAD65 is membrane-associated. Here we study the intracellular distribution of GAD67 in neurons, pancreatic β-cells, and fibroblasts transfected either with GAD65 and

Occupancy is one of the primary contributors to the energy performance gap, defined as the difference between actual and predicted energy usage, in buildings. This paper limits its scope to residential buildings, where occupant-centric consumption often goes unaccounted for in standard energy metrics. This paper starts from the hypothesis that a simple occupant energy efficiency label is needed to

This paper constructs the first long-run estimates of Irish regional GDP over the twentieth century and traces the relative economic performance of Ireland’s regions since independence. Using an array of data sources available at a county level, output in Agriculture, Industry and Services in benchmark census years is estimated. Applying a variety of alternative measures, we find a reduction in re

Sammanfattning Hur bra är vår perception av känslor i tal och vad är det som gör att vi uppfattar skillnader mellan dem? Finns det könsrelaterade och kulturella skillnader i uppfattningen? En undersökning har genomförts för att komma närmare svaren på dessa frågor. 16 personer med svenska och 16 med isländska som modersmål deltog i ett perceptionstest där de fick lyssna på 120 svenska yttranden u

Elevated concentrations of inorganic arsenic, one of the most potent environmental toxicants and carcinogens, have been detected in well water around Lake Poopó, Bolivia. This study aimed to assess human exposure to arsenic in villages around Lake Poopó, and also to elucidate whether the metabolism and detoxification of arsenic in this population is as efficient as previously indicated in other An

The end-Triassic mass extinction (c. 201.6 Ma) was one of the five largest mass-extinction events in the history of animal life. It was also associated with a dramatic, long-lasting change in sedimentation style along the margins of the Tethys Ocean, from generally organic-matter-poor sediments during the Triassic to generally organic-matter-rich black shales during the Jurassic. New core material

This paper extends the Common Correlated Effects Pooled (CCEP) estimator to homogeneous dynamic panels. In this setting CCEP suffers from a large bias when the time series dimension (T) is fixed. We develop a bias-corrected estimator that is valid for a multi-factor error structure provided that a sufficient number of cross-sectional averages, and lags thereof, are added to the model. We show that

IMPORTANCE: The impact of betaine treatment on outcome in patients with severe methylenetetrahydrofolate reductase (MTHFR) deficiency is presently unclear. OBJECTIVE: To investigate the effect of betaine treatment on development and survival in patients with severe MTHFR deficiency. DATA SOURCES: MEDLINE, EMBASE, and Cochrane databases between January 1960 and December 2012. STUDY SELECTION: Studi

Background: Ketogenic diet in children with epilepsy has a considerable impact on daily life and is usually adopted for at least 3 months. Our aim was to evaluate whether the introduction of an all-liquid ketogenic diet in an outpatient setting is feasible, and if an earlier assessment of its efficacy can be achieved.Methods: The authors conducted a prospective, observational study in a consecutiv

The attention to the environmental impact of plastics materials used in food packaging has produced several studies in the last decade and consumers have started wondering about the utility and the functions of food packaging. In fact, the use and the production of plastic polymers cause pollution due to the disposal and to the CO2 emission. Besides that, even if new polymers from organic and biol