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Gender inequality in human capital has been shown to be an important indicator of economic development, but has remained unexplored in a European history perspective. Using a new and large historical database on male and female literacy rates, new evidence is presented on the distribution of gender inequality in human capital in European regions in 1900 and 1960. An analysis is made of the distrib
OBJECTIVES: To determine whether national antiretroviral therapy (ART) coverage is associated with changes in the living arrangements of older adults.DESIGN: Retrospective analysis using 103 nationally representative surveys from 28 African countries between 1991 and 2015.METHODS: The sample consisted of individuals aged at least 60 years. We investigated how three measures of living arrangements
Abstract in Spanish Agallas provocadas por Aditrochus coihuensis (Hymenoptera: Pteromalidae) sobre su hospedero, Nothofagus dombeyi, fueron colectadas en la vecindad de San Carlos de Bariloche, Argentina, durante la primavera de 2007. Las mismas fueron examinadas y clasifi cadas como exitosas o no, sobre la base de restos de insectos dentro de ellas y el diámetro del agujero de emergencia. Distint
Background: CD40 agonists have the potential to enhance the efficacy of standard of care chemotherapy and to trigger antitumor immunity. Preclinical models indicate that the success of this approach depends on appropriate sequencing of chemotherapy with a CD40 agonist. Preliminary efficacy results from the OPTIMIZE-1 Phase II study (NCT04888312) combining mitazalimab (anti-CD40) with mFFX chemothe
Legitimacy is a relational concept that refers to the perception that the actions undertaken by an actor or an institution are rightful and acceptable. In political terms, an actor enjoys legitimacy if the way it exercises its power is widely considered warranted. In the framework of a major global political process such as the implementation of the 2030 Agenda for Sustainable Development, legitim
Despite decades of promising preclinical validation and clinical translation, ischemic stroke still remains as one of the leading causes of death and disability worldwide. Within its complex pathophysiological signatures, thrombosis and inflammation, that is, thromboinflammation, are highly interconnected processes leading to cerebral vessel occlusion, inflammatory responses, and severe neuronal d
This paper studies the performativity of smart mobility expectations in envisioning urban futures. Smart mobility, or ICT-enabled transport services, are increasingly considered a necessary ingredient for sustainability transitions in cities. Expectations of smart mobility’s contribution to such a transition are constituted by a strong belief in the transformative potential of data collection and
Amelogenin self-assembly is a critical step in enamel matrix organization, supporting the spatial confinement of transient ACP and orchestrating hydroxyapatite nucleation and ordered growth. Studies have demonstrated that amelogenin self-assembles into nanoribbons by forming an amyloid-like structure that matches the cross-β pattern observed in the developing enamel matrix. However, molecular dete
The El Niño - Southern Oscillation (ENSO) influences the global climate and the variability in the terrestrial carbon cycle on interannual timescales. Two different expressions of El Niño have recently been identified: (i) central Pacific (CP) and (ii) eastern Pacific (EP). Both types of El Niño are characterised by above-average sea surface temperature anomalies at the respective locations. Studi
Non-endocrine events represent a heterogeneous group of complications occurring in children who survive long term after haematopoietic SCT. This review highlights the late sequel in a growing child. The preparative regimen itself with high-dose chemotherapy and/or radiotherapy (TBI) or the treatment given before the transplant procedure may cause organ damage with permanent sequel. Immune reconsti
Background: Sentinel lymph node biopsy is an established staging method in early breast cancer. After a negative biopsy, most institutions will not perform a completion axillary dissection. The present study reports the current axillary recurrence (AR) rate, overall and disease-free survival in the Swedish Multicenter Cohort Study. Methods: From 3534 patients with primary breast cancer <= 3 cm pro
Most existing traffic conflict indicators do not sufficiently take into account the severity of the injuries resulting from a collision had it occurred. Thus far, most of the indicators that have been developed express the severity of a traffic encounter as their proximity to a collision in terms of time or space.This paper presents the theoretical framework and the first implementation of Extende
Background: Geoeconomic variations in epidemiology, the practice of ventilation, and outcome in invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient data of four large observational studies. Methods: In this pooled analysis we harmonised individual patien
Våra ögon är viktiga, inte bara för vårt seende, utan också för att synkronisera vår inre biologiska klocka med dygnets 24 timmar. Den biologiska klockan som styr människors dygnsrytm regleras främst av det mönster av ljus och mörker som vi utsätts för under dygnet.Tidigare trodde man att de klassiska fotoreceptorerna, tapparna och stavarna, var de enda ljuskänsliga cellerna i ögat. På 1980-talet
