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There is compelling evidence to suggest that estrogen administration to women of climacteric age reduces subsequent myocardial infarction by some 50%. Accumulating data also suggests estrogens confer substantial protection from stroke. Given this rationale, it is prudent to suggest to regulatory bodies that estrogen treatment would have this indication. Estrogens have other well-defined, and less

The glymphatic system is a highly polarized cerebrospinal fluid (CSF) transport system that facilitates the clearance of neurotoxic molecules through a brain-wide network of perivascular pathways. Herein we have mapped the development of the glymphatic system in mice. Perivascular CSF transport first emerges in hippocampus in newborn mice,

Lokalförsörjningsavdelningen ansvarar för att universitetet har ändamålsenliga hållbara och kostnadseffektiva lokaler som stödjer utbildning forskning och samverkan, från behovsanalys till avtal, ekonomi och genomförande. Avdelningen utreder och planerar lokalbehov, kostnadsberäknar och konsekvensbedömer samt samordnar byggprojekt och kvalitetssäkrar beställningar. Den tar fram lokalprogram, funThe Premises Provision Office ensures that the University has fit-for-purpose, sustainable and cost-effective premises that support education, research and collaboration. The Office analyses and plans premises needs, prepares cost estimates and impact assessments, and coordinates construction and refurbishment projects. It develops premises programmes and functional requirements in collaboration

Forskning i förpackningslogistik fokuserar på förpackningen och dess inverkan på logistiken. Forskningsområdena går från tillämpad industrirelaterad forsning till teori- och metodikutveckling inom förpackningslogistik. Fokus är för närvarade på hur förpackningen kan användas för att skapa värdeaddition och omfattar förpackningens konstruktionsprocess och hur den kan integreras med produktutvecklinResearch in packaging logistics focuses on packaging and its impact on logistics. The research areas are ranging from applied, industry related research to theoretical and methodological developments for the packaging logistics discipline. The focus is currently on how the package can be used to create an added value and starts with the packaging design process and how it can be integrated with th

The predicament in which we find ourselves today is that many professionals lack a sufficient grounding in formal methods, tools and techniques to enable them to make an appropriate selection for different kinds of problem. This can mean that complexity remains unrecognized and ambiguous problem situations are addressed as if they were clear and straightforward, resulting in inadequate solutions t

Den övergripande målsättningen med Fördraget om Europeiska Unionens Funktionssätt är att skapa en social marknadsekonomi där fri konkurrens spelar en avgörande roll. Konkurrensreglerna som styr företagens handlande på marknaden i Sverige och inom EU strävar efter att förhindra handlande som kan begränsa effektiv konkurrens. Ur ekonomisk synvinkel är det nödvändigt att möjligheten finns att marknadThe general goal of the Treaty on the functioning of the European Union is to create a social market economy, where free competition is crucial. The Competition rules, governing the actions of the parties on the Swedish and EU market, aim to prevent conduct that may restrict effective competition. From an economic point of view it is necessary to have the ability to influence the market in order t

Perlecan is a heparansulfate proteoglycan found in basement membranes, cartilage, and several mesenchymal tissues that form during development, tumour growth, and tissue repair. Loss-of-function mutations in the perlecan gene in mice are associated with embryonic lethality caused primarily by cardiac abnormalities probably due to hemopericards. The aim of the present study was to investigate the m

Neurocan is a component of the extracellular matrix in brain. Due to its inhibition of neuronal adhesion and outgrowth in vitro and its expression pattern in vivo it was suggested to play an important role in axon guidance and neurite growth. To study the role of neurocan in brain development we generated neurocan-deficient mice by targeted disruption of the neurocan gene. These mice are viable an

The meiotic functions of Emi2, an inhibitor of the APC/C complex, have been best characterized in oocytes where it mediates metaphase II arrest as a component of the cytostatic factor. We generated knockout mice to determine the in vivo functions of Emi2—in particular, its functions in the testis, where Emi2 is expressed at high levels. Male and female Emi2 knockout mice are viable but sterile, in

Understreckare om den yazidiska tragedin

It is obviously expected that sustainable development is the primary target to raise prosperity and life standards of nations. It is necessary to ensure social, political, and economic stability. But what about the stimulus factors that motivate sustainable development? Can income inequality be one of them? Some literature has examined the role of income distribution on economic growth, but to te

The aim of this thesis is to explore what impacts the IDF’s Military Orders regarding water have on Palestinians in the West Bank, taking international humanitarian law (IHL) and International Convention on Civil and Political Rights (ICCPR) into consideration. Thus, to discover whether or not Israel’s actions are compatible with IHL and treats everyone equal before the law, as stated in ICCPR Art

Water is a necessity for human survival, and a lack of sufficient clean water can have severe negative impacts on human health, economic activity, food security and societal relations. Increasing demand on water resources around the globe often leads to conflicts between different water users who compete for available supplies. The Murray Darling Basin (MDB) in Australia is an area that faces many

Produced as a tissue defence response to hypoxia and inflammation, growth differentiation factor-15 (GDF-15) is elevated in people receiving metformin treatment. To gain insight into the relationship of GDF-15 with metformin and major cardiovascular risk factors, we analysed the data from the SUMMIT cohort (n = 1438), a four-centre, nested, case–control study aimed at verifying whether biomarkers