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Objectives Biologic agents have dramatically changed treatment of rheumatoid arthritis (RA). To date only scarce head-To-head data exist especially when the biological therapies are given as monotherapy without concomitant disease modifying drugs (DMARDs). Thus the objective of the current study is to evaluate treatment response of all available biological therapies with special focus on utility (

Context. X-ray extragalactic surveys are ideal laboratories for the study of the evolution and clustering of active galactic nuclei (AGN). Usually, a combination of deep and wide surveys is necessary to create a complete picture of the population. Deep X-ray surveys provide the faint population at high redshift, while wide surveys provide the rare bright sources. Nevertheless, very wide area surve

Popular Abstract in Swedish Transplantation av dopaminceller från mänskliga foster kan förbättra funktionen hos patienter med Parkinsons sjukdom (Lindvall 1997, Björklund 2000a). Man har kunnat visa att transplantaten har återställt dopaminproduktionen i striatum till normala nivåer i flera fall, och till 70-80% av normalt i majoriteten av de patienter som transplanterats i Lund. Transplantaten haTransplantation of embryonic human neural tissue can restore function in patients with Parkinson’s disease, but there is a severe shortage of donor tissue which limits the applicability of the technique. Embryonic neural tissue from other species, xenogeneic tissue, would provide a readily accessible donor tissue with the potential to help patients if the immunological reactions in the host could

Cancer kan drabba vem som helst och kan ha sitt ursprung i många olika områden i kroppen. Antalet nya cancerfall ökar varje år, men vissa typer av cancer har bättre prognos än andra. Den vanligaste cancertypen i Sverige är prostatacancer och den drabbar framför allt äldre män. Prostatacancer har god prognos och det finns effektiva metoder att helt bota prostat- acancer om den behandlas i ett tidigPurpose: Recent developments in external radiotherapy and its utilization with artificial in- telligence (AI) enables advanced treatment plans for a range of different disease sites. By adapting to the anatomy of the day, target coverage can be ensured while sparing more healthy tissue. The purpose of this project was to study the feasibility and benefits of daily cone beam computed tomography (CB

Nowadays, is becoming increasingly frequent holding events in outdoor environments, involving a large number of people, even though these spaces were not designed from a safe prospective, in the way that safety is defined today. In such events, high density conditions is an ongoing issue, as the evacuation becomes very complex, due to the space design and the interaction among the pedestrians. It

Title: Information Management in Kockums AB’s Supply Chain regarding Development Products – Driving Forces and Barriers to reach excellence
Authors: Fredrik Arborelius and Henrik Stenvinkel
Supervisors: Anders Jansson, Manager Design Support and Tactical Planning, Kockums AB
Dag Näslund, Associate Professor, Department of Industrial Management and Logistics, Lund Institute of Technolog

The principal rule of the common market is that goods and services are able to move freely across the borders of Member States. State monopolies in control of supply and demand are, therefore, only under exceptional circumstances compatible with the conditions of the common market. The compatibility of Swedish State monopolies with EC law is a controversial matter. The case-law of the ECJ lets us

Background: Thrombolysis is a common method in the treatment of lower extremity bypass graft occlusion. The purpose of this study was to investigate the results of thrombolytic therapy in the management of acute bypass graft occlusion and to identify risk factors for technical failure and amputation. Methods: All patients at two tertiary referral centers undergoing thrombolysis for acute graft occ

The presented thesis work is concerned with the study of molecular dynamics using liquid nuclear magnetic resonance (NMR) spectroscopy. Spin relaxation dispersion experiments in the rotating frame (R_1ρ) are employed to provide a detailed, atomic-resolution view of protein dynamics. Comprehensive investigations of ¹⁵N backbone and ¹³C methyl side-chain confor

Popular Abstract in Swedish Bröstcancer är den vanligaste dödsorsaken bland cancersjuka kvinnor. Därför rekommenderas regelbundna mammografiska hälsokontroller för tidig diagnostik och snar behandling för att förbättra prognosen. I Sverige rekommenderas kontroller för kvinnor mellan 40-74 år. Mammografiska hälsokontroller medför dock även risker, såsom till exempel behov av kompletterande bröstundOne side-effect of breast cancer (BC) screening is a false-positive mammogram among healthy women. That is, finding(s) on a screening mammogram that lead to additional breast examinations but where the woman is eventually considered free from BC. There is evidence of short-term psychosocial consequences of false-positive BC screening. Regarding long-term consequences, research findings are inconsi

Popular Abstract in English Energy savings and climate change mitigation have been discussed in the world since the oil crisis in the 1970s and the building sector has been seen as one of the largest contributors to global warming effects in the world. Energy efficiency in buildings is a critical issue to be addressed in order to reduce electricity energy used in buildings and is one of the main tMozambique, situated in south-east Africa, has sub-tropical and tropical climate and plenty of natural resources for energy production. The country is however poor, and only about 25% of the population has access to electricity from the grid. A very large part of the energy used in the country is used in the residential sector, and there is a general lack of knowledge, regulations and tools concer

Background and objective: Human studies of arterio-venous (AV) differences in drug concentrations and the consequences for pharmacokinetic modelling and concentration-effect relationships are very limited. We therefore investigated the intravenous and intra-arterial concentrations of alcohol (ethanol) during the absorption, distribution and elimination stages of alcohol metabolism in healthy men.

Glycosaminoglycans (GAGs) are polysaccharides produced by essentially all mammalian cells. Due to their enormous structural diversity, they are involved in many biological processes both in health and disease, including all stages of tumor progression. GAGs are normally attached to a core protein as a part of a proteoglycan; however, GAG biosynthesis can be induced by compounds composed of a xylos

AbstractPhysical exhaustion can constrain human ascending work capacity and performance during emergency evacuation on stairs. The overall aim of this research was to explore and compare stair ascending capacities and physiological limitations during two different strategies: self-preferred pace in three different public stairways in the field, and controlled pace in a laboratory on a stair machin

Importance: Comprehensive and timely monitoring of disease burden in all age groups, including children and adolescents, is essential for improving population health.Objective: To quantify and describe levels and trends of mortality and nonfatal health outcomes among children and adolescents from 1990 to 2015 to provide a framework for policy discussion.Evidence Review: Cause-specific mortality an

Chronic pain including temporomandibular disorder (TMD) pain involves a complex interplay between peripheral and central sensitization, endogenous modulatory pathways, cortical processing and integration and numerous psychological, behavioral and social factors. The aim of this study was to compare spectroscopic patterns of N-Acetyl-aspartate (NAA), total creatine (tCr), choline (Cho), myo-inosito

Background: Patent foramen ovale (PFO) is a contributor to embolic stroke of undetermined source (ESUS). Subgroup analyses from previous studies suggest that anticoagulation could reduce recurrent stroke compared with antiplatelet therapy. We hypothesised that anticoagulant treatment with rivaroxaban, an oral factor Xa inhibitor, would reduce the risk of recurrent ischaemic stroke compared with as

BACKGROUND: Comparable data on the global and country-specific burden of neurological disorders and their trends are crucial for health-care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study provides such information but does not routinely aggregate results that are of interest to clinicians specialising in neurological conditions. In this syst

The ice cover presence on the surface of a lake insulates the water body from the atmosphere. This prevents or reduces the influence of processes which depend on the exchange between the atmosphere and the water surface. This implies significant reduction or elimination of some processes taking place at the open water surface; for instance, a substantial reduction in solar energy penetrating to th

Surrogate measures of safety (SMoS) are meant to function as tools to investigate traffic safety. The term surrogate indicates that these measures do not rely on crash data; instead, they focus on identifying safety critical events (or near-crashes) in traffic, which can be used as an alternative to crash records. The overall aim of this thesis is to explore which SMoS are suitable when analysing