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Datorbaserad litteratursökning

Scientific communication presumes a well functioning infor¬mation and documentation system. Information retrieval systems have been designed for making possible rapid and precise answers to inquiries. This report includes (1) a short survey of international and national documentation activities, (2) a description of rules and criteria to be used and the way these can be applied in an information r

Modeling of the degradation of elastic properties due to the evolution of ductile damage

An elasto-plastic constitutive model for porous materials is formulated within the thermodynamic framework. The formulation facilitates a natural modeling of damage as well as growth and the shrinkage of voids. Metal plasticity is used for demonstrating the possibilities of the formulation. The yield function employed is assumed to depend upon the void-volume fraction, whereas the free energy is d

Antidepressant drug effects in vivo: Focus on pharmacokinetic and pharmacodynamic responses in different experimental paradigms

Popular Abstract in Swedish Leverencefalopati (LE) är ett neuropsykiatriskt sjukdomstillstånd som kan ses i samband med en försämrad leverfunktion. Den bakomliggande orsaken till LE är ofta levercirrhos (skrumplever) p.g.a. alkoholmissbruk, men andra orsaker såsom kronisk hepatit, kirurgi, och olika gifter kan också ligga bakom detta. Vid levercirrhos försämras leverns blodflöde p.g.a. en ökad kärPharmacokinetic and pharmacodynamic activities of the antidepressants venlafaxine (VEN) and citalopram (CIT) were investigated in the portacaval shunted (PCS) rat, a model of chronic hepatic encephalopathy (HE), and normal/control rats. The levels of VEN in serum and brain were higher in PCS rats than in controls after a single injection and chronic treatment with VEN (10 mg/kg). After reducing th