Sökresultat

Background Clinical classification of rare sequence changes identified in the breast cancer susceptibility genes BRCA1 and BRCA2 is essential for appropriate genetic counselling of individuals carrying these variants. We previously showed that variant BRCA1 c.5096G>A p.Arg1699Gln in the BRCA1 transcriptional transactivation domain demonstrated equivocal results from a series of functional assays,

Today’s global competition forces manufacturing companies to re-evaluate their existing processes, technologies, manufactured parts and services in order to focus on strategic activities. The question whether to make or to buy goods or services represents a problem faced by many companies when deciding between keeping technologies/processes in-house or purchasing them from an outside supplier. In

Ring-Contraction of sugar-derived epoxy alcohols, functionalised in position 1 and 6, by treatment with lithium bromide and N, N, N', N'-tetramethylurea in refluxing toluene gave enantiomerically pure a,b-unsaturated aldehydes of furanosides. O-Glycosidic epoxy alcohols gave only one, easily purified, aldehyde in approximately 30-60% yield depending on the substitution pattern. C-Glycosidic epoxy

It has been generally accepted that residual cartilage and subchondral bone has to be removed in order to get bony fusion in arthrodeses. In 1998 we reported successful fusion of 11 rheumatoid ankles, all treated with percutaneous fixation only. In at least one of these ankle joints there was cartilage left. More than 25 rheumatoid patients with functional alignment in the ankle joint have subsequ

Popular Abstract in Swedish Det finns ett starkt samband mellan en förenings struktur och dess egenskaper. En detaljerad tredimensionell bild av en förenings struktur på molekylnivå är därför grundläggande information för att förstå dess reaktivitet, stabilitet och fysikaliska egenskaper. Röntgenkristallografi är ett utmärkt redskap för att ta reda på ett ämnes struktur i en kristall. En kristallsThis thesis focuses on i) the effect of packing on the molecular geometry ii) packing arrangements of neutral Pd(II) and Pt(II) complexes iii) the trans influence in Pt(II) complexes iv) the differences in bonding in corresponding Pd(II) and Pt(II) complexes and v) the geometry of Pd(II) complexes with potential catalytic properties. Detailed three-dimensional structural information at the atomic

Popular Abstract in Swedish Det kvinnliga könshormonet östrogen utövar sin effekt via två bindningsprotein (receptorer) benämnda ERa och ERb. Då östrogen binder till receptorn aktiverar alternativt inaktiverar detta komplex sekvenser av DNA molekylen. Således reglerar den aktiverade receptorn för östrogen genaktivitet och därmed syntes av proteiner viktiga för den normala cell- och vävnadsfunktionEstrogen receptors (ER) are expressed not only in classical target organs for estrogen like breast and uterus, but also in male reproductive system as well as in non-reproductive organs such as brain, liver and bone. The functions of ER are quite well known in reproductive organs but less information is available regarding their function in vascular tissue. The objective of this thesis was to inve

Advances in understanding how cancer cells interact with the immune system allowed the development of immunotherapeutic strategies, harnessing patients’ immune system to fight cancer. Dendritic cell-based vaccines are being explored to reactivate anti-tumor adaptive immunity. Immune checkpoint inhibitors and chimeric antigen receptor T-cells (CAR T) were however the main approaches that catapulted

Thesis Purpose: This study explores the major drivers and barriers to eco-innovation in Scandinavian and Finnish furniture companies, examining the influence of company size and age. The findings benefit stakeholders including businesses, policymakers, professionals, investors, and consumers. Theoretical Perspective: This study’s theoretical framework was developed through an exploration of eco-in

Rationale & Objective: Chronic kidney disease (CKD) is complicated by abnormalities that reflect disruption in filtration, tubular, and endocrine functions of the kidney. Our aim was to explore the relationship of specific laboratory result abnormalities and hypertension with the estimated glomerular filtration rate (eGFR) and albuminuria CKD staging framework. Study Design: Cross-sectional in

Background: Olfaction and gustation underlie behaviors that are crucial for insect fitness, such as host and mate selection. The detection of semiochemicals is mediated via proteins from large and rapidly evolving chemosensory gene families; however, the links between a species' ecology and the diversification of these genes remain poorly understood. Hence, we annotated the chemosensory genes from

More than three-quarters of primary breast cancers are positive for estrogen receptor alpha (ER; encoded by the gene ESR1), the most important factor for directing anti-estrogenic endocrine therapy (ET). Recently, mutations in ESR1 were identified as acquired mechanisms of resistance to ET, found in 12% to 55% of metastatic breast cancers treated previously with ET. We analyzed 3217 population-bas

Denna doktorsavhandling undersöker samtal om personliga problem i mötet med en specialist i radio. I synnerhet handlar studien om den dynamiska process då förståelse skapas – när upplevelser av personliga bekymmer förklaras och definieras som problem av särskilda slag. Denna meningsskapande process undersöks i detalj så som den utspelar sig i dialoger i radio och mellan programdeltagare och radiolThe dissertation examines how personal troubles are talked about in an encounter with a professional on the public arena of radio broadcasting, where the professional has to meet the challenge of making professional advice not only useful for the person seeking help, but also relevant or interesting for the radio audience. The study explores the dynamic process of shaping an understanding of probl

10 0 år m ed N ils H ol ge rs so n En ny läsebok Den reformivrande fackorganisationen Sveriges allmänna folkskollärareförening tillsatte i januari 1901 en kommitté för att få fram en modern läsebok. Initiativtagare var Fridtjuv Berg och överlärare Alfred Dalin. Den senare önskade att boken fick en ”folklig svensk stämning alltige- nom, så att barnens bästa och vackraste intryck från det svenska he

https://www.ub.lu.se/en/sites/ub.lu.se.en/files/2006_nils_holgersson_100_ar.pdf - 2025-11-08

Microsoft Word - 2016Verksamhetsplan.docx Verksamhetsplan - Körcentrum Syd 2016 Inledning Nedanstående verksamhetsplan för år 2016 i Körcentrum Syd har fastställts av Körcentrum Syds styrelse, 2016-02-01. Körcentrum Syd är en centrumbildning inrättad av Lunds Universitet. I Körcentrum Syds styrelse är följande institutioner representerade: Lunds Universitet med Musikhögskolan i Malmö och Odeum, Ma

https://www.korcentrumsyd.lu.se/sites/korcentrumsyd.lu.se/files/2016verksamhetsplan.pdf - 2025-11-08

Looking at the success of certification schemes for energy use in residential housing Looking at the Success of Certification Schemes for Energy Use in Residential Housing The Case of the Klimahaus / Casa Clima Program in South Tyrol / Italy Thesis submitted in partial fulfilment of the requirements of the International Master in Environmental Sciences Degree at Lund University, Sweden Submitted b

https://www.lumes.lu.se/sites/lumes.lu.se/files/uberbacher_dietmar.pdf - 2025-11-08

The Year In Review: The Director Looks Back at 2021 - The Raoul Wallenberg Institute of Human Rights and Humanitarian Law Skip to content Search for: Search Button Home About Us Who We Are Our History About Raoul Wallenberg Our Theory of Change Staff Opportunities Annual Reports Whistleblower Our work What we do Multi-Disciplinary Research Higher Education Strategic Advice and Analysis Outreach Ev

https://rwi.lu.se/2021/06/02/the-year-in-review-2021/ - 2025-11-08

På Siciliens östkust strax söder om Syrakusa, ligger ett långsmalt naturområde som följer kusten längs halvön Maddalenas sydspets ut till udden Capo Murro di Porco. Det är en obebyggd kustremsa sånär som på en fyrbyggnad med två angränsande stenhus. Naturen domineras av det klippiga landskapet och de tre byggnaderna som kommit att smälta in i omgivningen. I detta arbete, som är en fallstudie som Capo Murro di Porco is situated in a narrow natural area that runs along the coast of the peninsula of Maddalena, just south of Syracuse on the east coast of Sicily. It is an area of stunning nature with dramatic topography, steep cliff sides and sparse vegetation. On the very line marking the transition from low vegetation to bare rock on the horn of the peninsula, a lighthouse and two rugged low

Direct engagement Archives - Page 6 of 9 - The Raoul Wallenberg Institute of Human Rights and Humanitarian Law Skip to content Search for: Search Button Home About Us Who We Are Our History About Raoul Wallenberg Our Theory of Change Staff Opportunities Annual Reports Whistleblower Our work What we do Multi-Disciplinary Research Higher Education Strategic Advice and Analysis Outreach Evaluation of

https://rwi.lu.se/category/direct-engagement/page/6/ - 2025-11-08

Curriculum vitae MARTINA ANGELA CARETTA, PHD Birth date : 29th April 1986 Citizenships : Sweden and Italy martina_angela.caretta@keg.lu.se PROFESSIONAL EXPERIENCE January 2021- Senior Lecturer Human Geography Department, Lund University, Sweden August 2016 – December 2020 Assistant Professor of Geography Dept. of Geology and Geography, West Virginia University, USA December 2016 – November 2017 UN

https://www.keg.lu.se/en/sites/keg.lu.se.en/files/2022-02/MartinaA_Caretta_CV_220127.pdf - 2025-11-08