Evaluation of immunophenotype in diffuse large B-cell lymphoma and its impact on prognosis
Diffuse large B-cell lymphoma (DLBCL) has been shown to be comprised of at least two prognostic entities, depending on its resemblance to normal germinal center or activated B cells, using global gene expression profiling. Also, the expression patterns of bcl-6, CD10 and IRF-4 ( also known as MUM1) have been suggested as alternative means of identifying the germinal- and nongerminal center ( activ