Chronic inflammation has been strongly associated with tumor progression, but the underlying mechanisms remain elusive. Here we demonstrate that E3 ligase Itch and deubiquitinase Cyld formed a complex via interaction through 'WW-PPXY' motifs. The Itch-Cyld complex sequentially cleaved Lys63-linked ubiquitin chains and catalyzed Lys48-linked ubiquitination on the kinase Tak1 to terminate inflammato

This study uses a cognitive test score, the Swedish Military Enlistment test taken at age 18, to identify whether the ethnic employment and income gap in Sweden is caused by a pre-market skill gap and/or ethnic discrimination. The employment gap and income gap are estimated for males born in Sweden with different ethnic backgrounds: their parents were born in Sweden or in southern Europe or outsid

Plasmonic sensing has been an important multidisciplinary research field and has been extensively used in detection of trace molecules in chemistry and biology. The sensing techniques are typically based on surface-enhanced spectroscopies and surface plasmon resonances (SPRs). This review article deals with some recent advances in surface-enhanced Raman scattering (SERS) sensors and SPR sensors us

Reactions of the lightly stabilized triosmium cluster [Os-3(CO)(8){mu(3)-Ph2PCH2P(Ph)C6H4}(mu-H)] with tri(2-thienyl)phosphine (PTh3) and tri(2-furyl)phosphine (PFu(3)) are described and compared to analogous reactions with PPh3. At room temperature, a number of products are isolated: [Os-3(CO)(10)(mu-dppm)] from CO addition, [Os-3(CO)(8)(PR3){mu(3)-Ph2PCH2P(Ph)C6H4}(mu-H)] from phosphine addition

Background, aim, and scope We strive to predict consequences of genetically modified plants (GMPs) being cultivated openly in the environment, as human and animal health, biodiversity, agricultural practise and farmers' economy could be affected. Therefore, it is unfortunate that the risk assessment of GMPs is burdened by uncertainty. One of the reasons for the uncertainty is that the GMPs are int

Measurements of multiparticle azimuthal correlations (cumulants) for charged particles in p-Pb at root s(NN) = 5.02 TeV and Pb-Pb at root s(NN) = 2.76 TeV collisions are presented. They help address the question of whether there is evidence for global, flowlike, azimuthal correlations in the p-Pb system. Comparisons are made to measurements from the larger Pb-Pb system, where such evidence is esta

In this paper, a mathematical model is presented by which the cutting forces in gear form milling process are predicted using the mechanistic approach. To use this approach, a detailed description of the chip geometry is needed. Eccentricity and run-out tool errors are considered, which is of great importance as the chip thickness will by these errors vary for the subsequent cuts. The chip geometr

Background: Some patients with allergic asthma treated with anti-IgE (Xolair (R)) do not become symptom free. Better criteria for response assessment than allergy skin tests or IgE determination are needed. The impact of the size of the disease relevant allergen-specific IgE antibody fraction, i.e. the percentage of IgE antibody of total IgE, was evaluated in cat allergic patients treated with the

Past, present, and possible future changes in the Baltic Sea acid-base and oxygen balances were studied using different numerical experiments and a catchment-sea model system in several scenarios including business as usual, medium scenario, and the Baltic Sea Action Plan. New CO2 partial pressure data provided guidance for improving the marine biogeochemical model. Continuous CO2 and nutrient mea

The Earthshine telescope project is a collaborative effort between Lund Observatory (LO) in Sweden and the Danish Meteorological Institute (DMI) with the purpose of constructing one or more robotic telescopes to record the albedo of the Earth over a long time. The objective is to measure long-term development of the global cloud cover and reflectivity for climate modeling. A 1% change in the Earth

The ontogeny of continent-wide navigation mechanisms of the individual organism, despite being crucial for the understanding of animal movement and migration, is still poorly understood. Several previous studies, mainly conducted on passerines, indicate that inexperienced, juvenile birds may not generally correct for displacement during fall migration. Waterbirds such as the mallard (Anas platyrhy

Occasional fog is a critical water source utilised by plants and animals in the Namib Desert. Fog basking beetles (Onymacris unguicularis, Tenebrionidae) and Namib dune bushman grass (Stipagrostris sabulicola, Poaceae) collect water directly from the fog. While the beetles position themselves optimally for fog water collection on dune ridges, the grass occurs predominantly at the dune base where l

INTRODUCTION: Bisphosphonates have been shown to reduce osteoclastic activity and enhance pin fixation in both experimental and clinical studies. In this prospective, randomized study of high tibial osteotomy using the hemicallotasis (HCO) technique, we evaluate whether treatment by one single infusion of zoledronic acid can enhance the pin fixation. MATERIALS AND METHODS: 46 consecutive patients

This report presents a large number of optimal PI and PID parameters for a batch of 134 benchmark process models representative for the process industry. This information can e.g. be used as a reference for other controller design methods. The optimal parameters have been derived using the MATLAB®-based software called SWORD, which determines the PI or PID controller that gives the best load distu

The structures and dynamics of unsteady laminar partially premixed methane/air Bunsen flames are studied by means of numerical simulations, OH and CH PLIF imaging, and high speed chemiluminescence imaging employing a high framing speed intensified charge coupled device camera. The Bunsen burner has a diameter of 22 mm. Rich methane/air mixtures with an equivalence ratio of 1.5 are injected from th