CONTEXT: The COLIA1 gene is a strong candidate for susceptibility to osteoporosis. The causal genetic variants are currently unclear, but the most likely are functional polymorphisms in the promoter and intron 1 of COLIA1. OBJECTIVE: The objective of the study was to determine whether promoter and intron 1 polymorphisms of COLIA1 or haplotypes defined by these polymorphisms regulate bone mineral d

NOx storage and reduction experiments have been performed with stationary operation of a heavy-duty diesel engine rig. An optimization of the NOx reduction performance has been done using experimental design. The adjustable parameters in this study were cycle time, injection time, injection rate and bypass time (period of reduced flow through catalysts). NOx was reduced by 50-60% (3.3-4.1 g/kWh) w

Lipids have been implicated in ß-cell stimulus-secretion coupling. Thus, lipases in ß-cells would be required to generate coupling factors from intracellular lipids. Indeed, we found that glucose stimulates lipolysis in rodent islets and clonal ß-cells. Lipolysis and diglyceride lipase activity in islets are abolished by orlistat, a pan-lipase inhibitor. Moreover, orlistat dose-dependently inhibit

We have studied the influence of bulk inversion asymmetry (BIA) and the relativistic part of the low-symmetry interface Hamiltonian (IH) on intersubband optical transitions, induced by linearly polarized light, between strongly hybridized electron-hole states in asymmetrical InAs/GaSb broken-gap quantum wells grown along the [001] direction. The self-consistent calculations were performed using th

We present multiwavelength observations of a gamma-ray burst detected byINTEGRAL (GRB 030227) between 5.3 hours and ~ 1.7days after the event. Here we report the discovery of a dim opticalafterglow (OA) that would not have been detected by many previoussearches due to its faintess (R ~ 23). This OA was seen to declinefollowing a power law decay with index alpha R = -0.95 +/-0.16. The spectral inde

A fast, narrow-band computer model, FASTNB, which predicts the radiation intensity in a general nonisothermal and nonhomogeneous combustion environment, has been developed. The spectral absorption coefficients of the combustion products, including carbon dioxide, water vapor, and soot, are calculated based on the narrow-band model. FASTNB provides an accurate calculation at reasonably high speed.

In insects, olfactory receptor neurons (ORNs) are located in cuticular sensilla, that are present on the antennae and on the maxillary palps. Their axons project into spherical neuropil, the glomeruli, which are characteristic structures in the primary olfactory center throughout the animal kingdom. ORNs in insects often respond specifically to single odor compounds. The projection patterns of the

A search for excited lepton production in e(+)e(-) collisions was performed using the data collected by the DELPHI detector at LEP at centre-of-mass energies ranging from 189 GeV to 209 GeV, corresponding to an integrated luminosity of approximately 600 pb(-1). No evidence for excited lepton production was found. In searches for pair-produced excited leptons, lower mass limits were established in

OBJECTIVES. The aim of the present study was to describe the 5-year incidence of retinopathy in type 1 diabetes mellitus and to characterize risk indicators for the development and progression of retinopathy. DESIGN. A cross-sectional study of type 1 diabetic patients taken care of at a medical department. SETTING. All type 1 diabetic patients attending the Department of Internal Medicine, Univers

In this paper self-adjoint realizations in Hilbert and Pontryagin spaces of the formal expression L-alpha = L + psi are discussed and compared. Here L is a positive self-adjoint operator in a Hilbert space H with inner product , a is a real parameter, and p in the rank one perturbation is a singular element belonging to H-nH-n+1 with n >= 3, where {H-s}(s=-infinity)(infinity) is the scale of Hilbe