The photoreceptors of the retina are afflicted by diseases that still often lack satisfactory treatment options. Although suitable drugs might be available in some cases, the delivery of these compounds into the eye and across the blood–retinal barrier remains a significant challenge for therapy development. Here, we review the routes of drug administration to the retina and highlight different op

This review summarizes – with the practicing hematologist in mind – the methods used to determine measurable residual disease (MRD) in everyday practice with some future perspectives, and the current knowledge about the prognostic impact of MRD on outcome in acute myeloid leukemia (AML), excluding acute promyelocytic leukemia. Possible implications for choice of MRD method, timing of MRD monitorin

Introduction: About 70 million people worldwide are estimated to suffer from epilepsy. Despite a large variety of old and new antiepileptic drugs on the market, about 30% of people with epilepsy do not become seizure-free with medical treatment. This is a major individual and public health burden. Most of these difficult-to-treat patients are having focal seizures. Zonisamide is effective against

Gas bubbles in a water-filled cavity move upward because of buoyancy. Near the roof, additional forces come into play, such as Lifshitz, double layer, and hydrodynamic forces. Below uncharged metallic surfaces, repulsive Lifshitz forces combined with buoyancy forces provide a way to trap micrometer-sized bubbles. We demonstrate how bubbles of this size can be stably trapped at experimentally acces

Zr/TiO 2 anatase photocatalysts with 0.5, 1, 2, 5 and 7.5 mol.% Zr were prepared using pressurized hot water crystallization and their photocatalytic activity was explored in acid orange 7 photodegradation. Parent TiO 2 was also prepared and tested. From all tested photocatalysts, 2 mol.% Zr/TiO 2 showed the highest photoactivity, and 7.5 mol.% Zr/TiO 2 showed the lowest photoactivity. The po

Relative free energies for the binding of nine cyclic carboxylate ligands to the octa-acid deep-cavity host were calculated at the combined density-functional theory and molecular mechanics (DFT/MM) level of theory. The DFT calculations employed the BLYP functional and the 6-31G∗ basis set for the ligand. We employed free-energy perturbations (FEP) with the reference-potential approach and used m

Parental longevity is associated with an increased life expectancy; results with regard to specific diseases are conflicting. There are limited data focusing on host characteristics and their effect on survival among multiple myeloma (MM) patients and individuals with monoclonal gammopathy of undetermined significance (MGUS). Therefore, our aim was to evaluate the impact of parental longevity on s

This paper investigates the outcome of the efforts to economically catch up during the so-called development era in French speaking West Africa. An attempt is made to measure and discuss key elements of social capability over the period 1930-1980 in Côte d'Ivoire and Senegal following Moses Abramovitz' interpretation of social capability. The paper distinguishes between four elements of social cap

Purpose: To provide a focused review of sickle cell retinopathy in the light of recent advances in the pathogenesis, multimodal retinal imaging, management of the condition, and migration trends, which may lead to increased prevalence of the condition in the Western world. Methods: Non-systematic focused literature review. Results: Sickle retinopathy results from aggregation of abnormal hemoglobin

The present article is an assessment of wastewater treatment processes in the oil refinery sector in Kazakhstan by comparing relevant experience of developed and developing countries. The legislation in this sphere, the treatment methods, the discharge process and the effect on the environment were evaluated following international and national regulations. In our study, the wastewater systems in

A resonant characteristic mode (CM) is useful for antenna design if it is properly excited and well matched to the source. In this paper, we consider the feed design for the excitation of the fundamental CM of a rectangular chassis. The tradeoff between the required number of capacitive coupling elements (CCE) and matching elements used for achieving a given antenna bandwidth is studied. The resul

The impact of soil metal pollution on plant communities has been studied extensively in the past.However, very little is known about the fungal species that co-occur with these plant communities onmetal polluted soils.We characterized the belowground fungal community in a heavy metal polluted anda non-polluted soil using 454 pyrosequencing. The fungal communities at both study sites were shown toc