Background: Enzalutamide (ENZ), an androgen receptor antagonist therapy, was approved for patients (pts) with mCRPC. However, in standard of care for mCRPC pts, change in prostate specific antigen (PSA) is not accepted as an efficacy response measurement and the radiological change is inadequately measured in an interpreter-dependent subjective analysis of bone scan. Therefore, an objective effica

This report on detailed aerosol characterization of fire smoke emissions is part of the Fire-Induced Radiological Integrated Assessment (FIRIA; CERN, Switzerland). In this study, carried out at Lund University, a number of materials were combusted in a cone calorimeter at varied heat fluxes. In a few experiments, the effect of reduced O2 content of supply air was investigated (vitiated conditions)

Purpose/Objective(s): To report the efficacy and utility of PSMA-based molecular targeted imaging in localized prostate cancer using 111In-J591 SPECT and 89Zr-J591 immuno-PET.Materials/Methods: Initiated in 2010, two sequential phase 0 prospective studies were performed on a total of 19 patients evaluating the roles of 111In-J591 SPECT and 89Zr-J591 immuno-PET. All patients had a baseline MRI foll

Introduction and Objectives: To compare pilot cohorts of men scheduled for radical prostatectomy imaged with novel antibody conjugates: Cohort 1 (111In-J591) single photon emission tomography (SPECT) or Cohort 2 (89Zr-J591) positron emission tomorgraphy (PET).Methods: 1) Cohort 1: Eight patients with abnormal digital rectal exam and biopsy proven prostate cancer were injected intravenously with tw

Andfåddhet är en subjektiv upplevelse och utgör ett ospecifikt, vanligt och potentiellt allvarligt symtom som tidigt bör utredas strukturerat tills orsaken är klarlagd, med fokus på att utesluta allvarliga differentialdiagnoser.Ökad medvetenhet om allvarlighetsgraden av andfåddhet kan minska fördröjning till diagnos samt förbättra prognosen, inte minst vid sällsynta sjukdomar såsom PAH (pulmonell Dyspnea is a common distressing symptom which may be a sign of a critically threatening condition and has been linked with increased hospitalizations, reduced exercise tolerance and increased mortality. The current neuropsychological model suggests that dyspnea arises due to an imbalance between respiratory drive and achieved ventilation. Pulmonary arterial hypertension (PAH) and chronic thromboem

This study aimed to conduct a systematic literature review (SLR) of the research performed in the plant-based meat analogues area. Historical, current, and future tendencies are discussed. The paper offers a comprehensive SLR coupled with a bibliometric analysis of the publication from 1972 to January 2022. The articles were obtained using a research string and precise inclusion and exclusion crit

The parents’ attitude toward vaccinating children and adolescents against coronavirus disease 2019 (COVID-19) remains inconsistent and needs further elucidation. The high rates of COVID-19 vaccine hesitancy in the Middle East and North Africa (MENA) region require intensive research to understand the determinants of this phenomenon. This study aimed to validate a version of the Parent Attitudes ab

Cervical cancer is one of the most recurrent and dangerous female cancers in Algeria and worldwide. It is mainly caused by human papillomaviruses (HPV), which can induce other cancers as well. Although it can be fatal, cervical cancer is one of the most preventable and manageable cancers. While HPV vaccination is the key weapon to win the battle against this pathology, it is still not approved in

We consider a nonlinear vertex-reinforced jump process (VRJP(w)) on Z with an increasing measurable weight function w : [1, ∞) → [1, ∞) and initial weights equal to one. Our main goal is to study the asymptotic behaviour of VRJP(w) depending on the integrability of the reciprocal of w. In particular, we prove that if (Equation presented). then the process is recurrent, that is, it visits each vert

In this work, we perform a detailed study of transition form factors for axial- vector meson production via the two-photon fusion process γ*γ* → 1++, with space-like virtual photons in the initial state and a P-wave axial-vector quarkonium in the final state. In this analysis, we employ the formalism of light-front quarkonium wave functions obtained from a solution of the Schrödinger equation for

(1) Background: Villous atrophy is an indication for small bowel capsule endoscopy (SBCE). However, SBCE findings are not described uniformly and atrophic features are sometimes not recognized; (2) Methods: The Delphi technique was employed to reach agreement among a panel of SBCE experts. The nomenclature and definitions of SBCE lesions suggesting the presence of atrophy were decided in a core gr

An expert panel convened by the European Alliance for Personalized Medicine (EAPM) reflected on achievements and outstanding challenges in Europe in mantle cell lymphoma (MCL). Through the prism of member state experience, the panel noted advances in outcomes over the last decade, but highlighted issues constituting barriers to better care. The list notably included availability of newer treatment

As the 2022 human monkeypox (HMPX) multi-country outbreak is spreading, the response of healthcare workers (HCWs) is central to mitigation efforts. The current study aimed to evaluate HMPX knowledge and confidence in diagnosis and management among HCWs in Kuwait. We used a self-administered questionnaire distributed in July–August 2022 through a snowball sampling approach. The survey items evaluat

Given the significance of entrepreneurial women’s contribution to the tourism industry and the fifth UN Sustainable Development Goal (gender equality) this study aims to investigate: first, the interrelationship between women entrepreneurship, creating shared value, and women’s empowerment; and second, the effect of gender-based discriminations on women’s entrepreneurship, creation shared value, a

Background: There are no evidence-based recommendations on the optimal time point to initiate non-vitamin K antagonist oral anticoagulants (NOACs) after acute ischemic stroke in patients with atrial fibrillation. We aimed to investigate the efficacy and safety of early versus delayed initiation of NOAC in these patients. Methods: TIMING (Timing of Oral Anticoagulant Therapy in Acute Ischemic Strok

The present study uses large-eddy simulations (LES) to identify the underlying mechanism that governs the ignition and stabilization mechanisms of ECN Spray A flame for different injection pressures (Pinj) and ambient temperatures (Tam). Two Pinj of 50 MPa and 150 MPa, as well as two Tam of 750 K and 900 K are considered. The numerical model is validated against the experimental fuel penetration,

Group A streptococci have evolved multiple strategies to evade human antibodies, making it challenging to create effective vaccines or antibody treatments. Here, we have generated antibodies derived from the memory B cells of an individual who had successfully cleared a group A streptococcal infection. The antibodies bind with high affinity in the central region of the surface-bound M protein. Suc

Many environmental risk factors for hepatobiliary cancers are known but whether they are associated with specific cancer types is unclear. We present here a novel approach of assessing standardized incidence ratios (SIRs) of previously diagnosed comorbidities for hepatocellular carcinoma (HCC), gallbladder cancer (GBC), cholangiocarcinoma (CCA) and ampullary cancer. The 13 comorbidities included a

Agriculture faces risks due to increasing stress from climate change, particularly in semi-arid regions. Lack of understanding of crop water requirement (CWR) and irrigation water requirement (IWR) in a changing climate may result in crop failure and socioeconomic problems that can become detrimental to agriculture-based economies in emerging nations worldwide. Previous research in CWR and IWR has