Published 2 March 2018 A completely new classification of diabetes which also predicts the risk of serious complications and provides treatment suggestions. We are now seeing the first results of ANDIS – a study covering all newly diagnosed diabetics in southern Sweden — published in The Lancet Diabetes & Endocrinology. The major difference from today’s classification is that type 2 diabetes actua

https://www.ludc.lu.se/article/paradigm-shift-diagnosis-diabetes - 2025-04-29

Published 23 February 2017 Obesity is associated with reduced muscle mass and impaired metabolism. Epigenetic changes that affect the formation of new muscle cells may be a contributing factor, according to new research from Lund University, Sweden. In a new study, doctoral student Cajsa Davegårdh has studied so-called DNA methylation in muscle stem cells in both obese and non-obese individuals. D

https://www.ludc.lu.se/article/obesity-reprogrammes-muscle-stem-cells - 2025-04-29

Published 24 February 2017 BEAt-DKD (“Biomarker Enterprise to Attack Diabetic Kidney Disease”), a unique public private partnership funded by the Innovative Medicines Initiative (IMI), member companies from the European Federation of Pharmaceutical Industries and Associations (EFPIA), the Juvenile Diabetes Research Foundation (JDRF) and the state of Switzerland has announced the launch of a 5-¬¬ye

https://www.ludc.lu.se/article/innovative-medicines-initiative-project-precision-medicine-dkd - 2025-04-29

Published 24 February 2017 Almost 0.5 billion people have diabetes globally, many of whom are unaware of their condition; within the next two decades, this number is expected to double, largely owing to a growing, ageing, and increasingly industrialized global population. Lund University receives 100 million SEK from The Swedish Foundation of Strategic Research to help stop this development. “This

https://www.ludc.lu.se/article/100-million-sek-personalized-medicine-diabetes - 2025-04-29

Published 24 February 2017 Throughout our lives, our genes are affected by the way we live. Diet, exercise, age and diseases create imprints that are stored in something called methylome. Now, for the first time, researchers at the Lund University Diabetes Centre in Sweden have been able to map the entire methylome in the pancreatic islets which produce insulin, and the researchers have made sever

https://www.ludc.lu.se/article/unique-mapping-methylome-insulin-producing-islets - 2025-04-29

Published 31 May 2018 New population study from Lund University Risk of bladder cancer by disease severity in relation to metabolic factors and smoking; a prospective pooled cohort study of 800,000 men and womenPrevious studies on metabolic factors and bladder cancer (BC) risk have shown inconsistent results and have commonly not investigated associations separately by sex, smoking, and tumor inva

https://www.lupop.lu.se/article/risk-bladder-cancer-disease-severity-relation-metabolic-factors-and-smoking - 2025-04-29

Published 17 May 2022 Registries are one way to provide longitudinal, observational data, giving rise to a range of possibilities in terms of audit and research. They allow examining approaches to management, which would not be feasible by a trial or where there was no trial data (currently or likely ever) available. In this Perspective, we will discuss aspects of their design, analysis, and use i

https://www.lupop.lu.se/article/perspectives-pain-registries - 2025-04-29

Published 19 May 2022 Epidemiologists commonly use an adjusted hazard ratio or incidence density ratio, or a standardized mortality ratio, to measure a difference in all-cause mortality rates. They seldom translate it into an age-, time-, or probability-based measure that would be easier to communicate and to relate to. Several articles have shown how to translate from a standardized mortality rat

https://www.lupop.lu.se/article/translating-all-cause-mortality-rate-ratios-or-hazard-ratios-age-longevity-and-probability-based - 2025-04-29

Published 20 May 2022 Results of randomized trials and observational studies can be difficult to communicate. Results are often presented as risk or survival functions stratified by the treatment or exposure (1, 2). However, a contrast between the stratified risk functions is often of primary interest. Here we propose a “twister” plot to visualize contrasts in risk over the duration of a study. Th

https://www.lupop.lu.se/article/twister-plots-time-event-studies - 2025-04-29

Published 23 May 2022 Psychosocial constructs can only be assessed indirectly, and measures are typically formed by a combination of indicators that are thought to relate to the construct. Reflective and formative measurement models offer different conceptualizations of the relation between the indicators and what is sometimes conceived of as a univariate latent variable supposed to correspond in

https://www.lupop.lu.se/article/constructed-measures-and-causal-inference-towards-new-model-measurement-psychosocial-constructs - 2025-04-29

Published 24 May 2022 Mendelian randomization (MR) is often used to estimate effects of time-varying exposures on health outcomes using observational data. However, MR studies typically use a single measurement of exposure and apply conventional instrumental variable (IV) methods designed to handle time-fixed exposures. As such, MR effect estimates for time-varying exposures are often biased, and

https://www.lupop.lu.se/article/mendelian-randomization-repeated-measures-time-varying-exposure - 2025-04-29

Published 25 May 2022 Lifetime risk measures the cumulative risk for developing a disease over one’s lifespan. Modeling the lifetime risk must account for left truncation, the competing risk of death, and inference at a fixed age. In addition, statistical methods to predict the lifetime risk should account for covariate-outcome associations that change with age. In this paper, we review and compar

https://www.lupop.lu.se/article/comparison-statistical-methods-predict-residual-lifetime-risk - 2025-04-29

Published 30 May 2022 The Diet, Cancer and Health—Next Generations (DCH-NG) study is a large population-based cohort study that was established as a resource for transgenerational research. The cohort is an extension of the Diet, Cancer and Health (DCH) cohort. The aim of this paper was to describe the study design and methods and to investigate the representativeness of participants by comparing

https://www.lupop.lu.se/article/cohort-profile-and-representativeness-participants-diet-cancer-and-health-next-generations-cohort - 2025-04-29

Published 1 June 2018 Karin Larsson's presentation from the GIS seminar is now available Read more here.

https://www.lupop.lu.se/article/what-gis-and-what-can-it-be-used - 2025-04-29

Published 1 June 2022 Recruiting participants to a clinical study is a resource-intensive process with a high failure rate. The Scottish Health Research Register (SHARE) provides recruitment support service which helps researchers recruit participants by searching patients’ Electronic Health Records (EHRs). The current study aims to evaluate the performance of SHARE in participant recruitment. Rea

https://www.lupop.lu.se/article/early-experience-opt-research-register-scottish-health-research-register-share-multi-method - 2025-04-29

Published 2 June 2022 Modern artificial intelligence techniques have solved some previously intractable problems and produced impressive results in selected medical domains. One of their drawbacks is that they often need very large amounts of data. Pre-existing datasets in the form of national cancer registries, image/genetic depositories and clinical datasets already exist and have been used for

https://www.lupop.lu.se/article/registries-databases-and-repositories-developing-artificial-intelligence-cancer-care - 2025-04-29

Published 3 June 2022 Background: The Danish National Patient Registry is a major resource for Danish epidemiology. Only a few studies have been conducted to check the validity of the reporting of systemic anticancer treatments. In this study, we assessed this validity for a range of cancer types over a long period of time. Patients and Methods: We extracted systemic anticancer treatment procedure

https://www.lupop.lu.se/article/high-validity-danish-national-patient-registry-systemic-anticancer-treatment-registration-2009-2019 - 2025-04-29

Published 7 June 2022 The DMSKW is a valuable structure in providing safety data on drug exposure during pregnancy and lactation in combination with information on disease activity up to 6 years postpartum. This article will be the reference for describing the methods of future publications from the DMSKW. Read the paper at https://journals.sagepub.com/doi/10.1177/17562864211054956

https://www.lupop.lu.se/article/german-multiple-sclerosis-and-pregnancy-registry-rationale-objective-design-and-first-results - 2025-04-29

Published 13 June 2022 Sibling comparison studies have the attractive feature of being able to control for unmeasured confounding by factors that are shared within families. However, there is sometimes a concern that these studies may have poor generalizability (external validity) due to the implicit restriction to families that are covariate-discordant, i.e., those families where at least two sib

https://www.lupop.lu.se/article/generalizability-and-effect-measure-modification-sibling-comparison-studies - 2025-04-29

Published 14 June 2022 Collinearity can be a problem in regression models. When examining the effects of an exposure at different time points, constrained distributed lag models can alleviate some of the problems caused by collinearity. Still, some consequences of collinearity may remain and they are often unexplored. We aimed to illustrate the effects of collinearity in the context of distributed

https://www.lupop.lu.se/article/reflection-modern-methods-visualizing-effects-collinearity-distributed-lag-models - 2025-04-29