A platform for safe handling of data at the medical faculty Infosäk will shortly publish complete information about the project. Meanwhile, you can read more here.

https://www.lupop.lu.se/article/infosak - 2025-09-05

Photo: flickr / Mitchell Joyce Laboratory-based animal research has revealed a number of exposures with multigenerational effects—ones that affect the children and grandchildren of those directly exposed. An important task for epidemiology is to investigate these relationships in human populations. Read the paper at https://academic.oup.com/aje/article/189/12/1600/5865443

https://www.lupop.lu.se/article/methodological-issues-population-based-studies-multigenerational-associations - 2025-09-05

Photo: Pixabay / Gerd Altmann In observational studies using routinely collected data, a variable with a high level of missingness or misclassification may determine whether an observation is included in the analysis. In settings where inclusion criteria are assessed after imputation, the popular multiple-imputation variance estimator proposed by Rubin (“Rubin’s rules” (RR)) is biased due to incom

https://www.lupop.lu.se/article/multiple-imputation-variance-estimation-studies-missing-or-misclassified-inclusion-criteria - 2025-09-05

Photo: Pixabay / Gerd Altmann A growing number of studies use data before and after treatment initiation in groups exposed to different treatment strategies to estimate “causal effects” using a ratio measure called the prior event rate ratio (PERR). Here, we offer a causal interpretation for PERR and its additive scale analog, the prior event rate difference (PERD). Read the paper at https://acade

https://www.lupop.lu.se/article/causal-interpretation-rate-change-methods-prior-event-rate-ratio-and-rate-difference - 2025-09-05

Image from pixabay / pearson0612 The coronavirus disease 2019 (COVID-19) pandemic and the coming transition to a postpandemic world where COVID-19 will likely remain as an endemic disease present a host of challenges and opportunities in epidemiologic research. Read the paper at https://academic.oup.com/aje/article/190/1/17/5874603

https://www.lupop.lu.se/article/what-now-epidemiology-wake-pandemic - 2025-09-05

Suppose that an investigator wants to estimate an association between a continuous exposure variable and an outcome, adjusting for a set of confounders. If the exposure variable suffers classical measurement error, in which the measured exposures are distributed with independent error around the true exposure, then an estimate of the covariate-adjusted exposure-outcome association may be biased. R

https://www.lupop.lu.se/article/reducing-bias-due-exposure-measurement-error-using-disease-risk-scores - 2025-09-05

Photo: Kennet Ruona In aspiring to be discerning epidemiologists, we must learn to think critically about the fundamental concepts in our field and be able to understand and apply many of the novel methods being developed today. We must also find effective ways to teach both basic and advanced topics in epidemiology to graduate students, in a manner that goes beyond simple provision of knowledge.

https://www.lupop.lu.se/article/simulation-tool-teaching-and-learning-epidemiologic-methods - 2025-09-05

Photo: Pixabay / Arek Socha Factorial Mendelian randomization is the use of genetic variants to answer questions about interactions. Although the approach has been used in applied investigations, little methodological advice is available on how to design or perform a factorial Mendelian randomization analysis. Read the paper at https://academic.oup.com/ije/article/49/4/1147/5542600?rss=1

https://www.lupop.lu.se/article/factorial-mendelian-randomization-using-genetic-variants-assess-interactions - 2025-09-05

Unmeasured confounding can bias the relationship between exposure and outcome. Sensitivity analyses generate bias-adjusted measures but these are not much used; this may change with the availability of the E-value (for evidence for causality in observational studies), appealing for its ease of calculation. Read the paper at https://academic.oup.com/ije/article/49/5/1509/5913108

https://www.lupop.lu.se/article/bias-factor-maximum-bias-and-e-value-insight-and-extended-applications - 2025-09-05

Photo: Pixabay / Colin Behrens We illustrate the method and some potential choices using data from England for men diagnosed with melanoma. Various marginal measures are presented and compared. Read the paper at https://academic.oup.com/ije/article/49/5/1614/5896134

https://www.lupop.lu.se/article/reference-adjusted-and-standardized-all-cause-and-crude-probabilities-alternative-net-survival - 2025-09-05

Fotograf: Håkan Röjder The PhD position is linked to the research project The long reach of the neighborhood: Health, education and earnings in Landskrona, Sweden, 1904-2015, funded by Handelsbankens forskningsstiftelser. The PhD student will work in this project in collaboration with other project members and will be affiliated with the Centre for Economic Demography at LUSEM (CED, www.ed.lu.se).

https://www.lupop.lu.se/article/phd-position-economic-history-neighborhood-effects-over-life-course - 2025-09-05

Find out how GDPR will affect you and your research! More information, including programme, here.

https://www.lupop.lu.se/article/gdpr-event - 2025-09-05

Photo: Pixabay / Gerd Altmann This paper describes the multiform, wave-missing and two-method designs, including their benefits, their impact on bias and power, and other factors that must be taken into consideration when implementing them in an epidemiological study design. Read the paper at https://academic.oup.com/ije/article/49/5/1702/5827680

https://www.lupop.lu.se/article/reflection-modern-methods-planned-missing-data-designs-epidemiological-research - 2025-09-05

Obesity is associated with reduced muscle mass and impaired metabolism. Epigenetic changes that affect the formation of new muscle cells may be a contributing factor, according to new research from Lund University, Sweden. In a new study, doctoral student Cajsa Davegårdh has studied so-called DNA methylation in muscle stem cells in both obese and non-obese individuals. DNA methylation is an epigen

https://www.ludc.lu.se/article/obesity-reprogrammes-muscle-stem-cells - 2025-09-05

BEAt-DKD (“Biomarker Enterprise to Attack Diabetic Kidney Disease”), a unique public private partnership funded by the Innovative Medicines Initiative (IMI), member companies from the European Federation of Pharmaceutical Industries and Associations (EFPIA), the Juvenile Diabetes Research Foundation (JDRF) and the state of Switzerland has announced the launch of a 5-¬¬year project (total budget 28

https://www.ludc.lu.se/article/innovative-medicines-initiative-project-precision-medicine-dkd - 2025-09-05

Almost 0.5 billion people have diabetes globally, many of whom are unaware of their condition; within the next two decades, this number is expected to double, largely owing to a growing, ageing, and increasingly industrialized global population. Lund University receives 100 million SEK from The Swedish Foundation of Strategic Research to help stop this development. “This is excellent news and a fa

https://www.ludc.lu.se/article/100-million-sek-personalized-medicine-diabetes - 2025-09-05

Throughout our lives, our genes are affected by the way we live. Diet, exercise, age and diseases create imprints that are stored in something called methylome. Now, for the first time, researchers at the Lund University Diabetes Centre in Sweden have been able to map the entire methylome in the pancreatic islets which produce insulin, and the researchers have made several important discoveries. U

https://www.ludc.lu.se/article/unique-mapping-methylome-insulin-producing-islets - 2025-09-05

Ska genetikforskare informera forskningsdeltagare om de upptäcker sjukdomsrisker hos deltagarna? Ja, skulle många säga, om informationen är till nytta för deltagarna. Men hur vet vi om komplex genetisk information är relevant för enskilda människor? Enligt Jennifer Viberg Johansson, aktuell med en ny avhandling i forsknings- och bioetik, behöver både etiker och genetiker förhålla sig till att nytt

https://www.diabetesportalen.lu.se/artikel/genetisk-risk-ska-forskare-beratta - 2025-09-05

Örebroforskare har identifierat tidiga förändringar i ämnesomsättningen hos barn som senare utvecklar typ 1-diabetes – ett viktigt steg för att kunna förebygga sjukdomen. Detta är ett av flera forskningsresultat som presenterades på Nordic Metabolomics Conference. – Vi har identifierat tidiga förändringar när det gäller ämnesomsättningen av fett som påverkar immunsystemet. Dessa förändringar sker

https://www.diabetesportalen.lu.se/artikel/forandringar-i-amnesomsattningen-paverkar-immunforsvaret-0 - 2025-09-05

Råg, havre eller vete spelar ingen större roll. Bara de innehåller fullkorn så skyddar de mot typ 2-diabetes. En portion havregrynsgröt och en fullkornsmacka om dagen räcker för att minska risken för diabetes med 34 procent hos män och 22 procent hos kvinnor, visar en stor nordisk studie. Studien, gjord av forskare på Chalmers och Cancerinstitutet i Köpenhamn ger en kraftfull bekräftelse av tidiga

https://www.diabetesportalen.lu.se/artikel/fullkorn-basta-skyddet-mot-typ-2-diabetes - 2025-09-05