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Methodological Issues in Population-Based Studies of Multigenerational Associations

Photo: flickr / Mitchell Joyce Laboratory-based animal research has revealed a number of exposures with multigenerational effects—ones that affect the children and grandchildren of those directly exposed. An important task for epidemiology is to investigate these relationships in human populations. Read the paper at https://academic.oup.com/aje/article/189/12/1600/5865443

https://www.lupop.lu.se/article/methodological-issues-population-based-studies-multigenerational-associations - 2025-08-25

Multiple-Imputation Variance Estimation in Studies With Missing or Misclassified Inclusion Criteria

Photo: Pixabay / Gerd Altmann In observational studies using routinely collected data, a variable with a high level of missingness or misclassification may determine whether an observation is included in the analysis. In settings where inclusion criteria are assessed after imputation, the popular multiple-imputation variance estimator proposed by Rubin (“Rubin’s rules” (RR)) is biased due to incom

https://www.lupop.lu.se/article/multiple-imputation-variance-estimation-studies-missing-or-misclassified-inclusion-criteria - 2025-08-25

On the Causal Interpretation of Rate-Change Methods: The Prior Event Rate Ratio and Rate Difference

Photo: Pixabay / Gerd Altmann A growing number of studies use data before and after treatment initiation in groups exposed to different treatment strategies to estimate “causal effects” using a ratio measure called the prior event rate ratio (PERR). Here, we offer a causal interpretation for PERR and its additive scale analog, the prior event rate difference (PERD). Read the paper at https://acade

https://www.lupop.lu.se/article/causal-interpretation-rate-change-methods-prior-event-rate-ratio-and-rate-difference - 2025-08-25

Reducing Bias Due to Exposure Measurement Error Using Disease Risk Scores

Suppose that an investigator wants to estimate an association between a continuous exposure variable and an outcome, adjusting for a set of confounders. If the exposure variable suffers classical measurement error, in which the measured exposures are distributed with independent error around the true exposure, then an estimate of the covariate-adjusted exposure-outcome association may be biased. R

https://www.lupop.lu.se/article/reducing-bias-due-exposure-measurement-error-using-disease-risk-scores - 2025-08-25

Simulation as a Tool for Teaching and Learning Epidemiologic Methods

Photo: Kennet Ruona In aspiring to be discerning epidemiologists, we must learn to think critically about the fundamental concepts in our field and be able to understand and apply many of the novel methods being developed today. We must also find effective ways to teach both basic and advanced topics in epidemiology to graduate students, in a manner that goes beyond simple provision of knowledge.

https://www.lupop.lu.se/article/simulation-tool-teaching-and-learning-epidemiologic-methods - 2025-08-25

Factorial Mendelian randomization: using genetic variants to assess interactions

Photo: Pixabay / Arek Socha Factorial Mendelian randomization is the use of genetic variants to answer questions about interactions. Although the approach has been used in applied investigations, little methodological advice is available on how to design or perform a factorial Mendelian randomization analysis. Read the paper at https://academic.oup.com/ije/article/49/4/1147/5542600?rss=1

https://www.lupop.lu.se/article/factorial-mendelian-randomization-using-genetic-variants-assess-interactions - 2025-08-25

Bias factor, maximum bias and the E-value: insight and extended applications

Unmeasured confounding can bias the relationship between exposure and outcome. Sensitivity analyses generate bias-adjusted measures but these are not much used; this may change with the availability of the E-value (for evidence for causality in observational studies), appealing for its ease of calculation. Read the paper at https://academic.oup.com/ije/article/49/5/1509/5913108

https://www.lupop.lu.se/article/bias-factor-maximum-bias-and-e-value-insight-and-extended-applications - 2025-08-25

Reference-adjusted and standardized all-cause and crude probabilities as an alternative to net survival in population-based cancer studies

Photo: Pixabay / Colin Behrens We illustrate the method and some potential choices using data from England for men diagnosed with melanoma. Various marginal measures are presented and compared. Read the paper at https://academic.oup.com/ije/article/49/5/1614/5896134

https://www.lupop.lu.se/article/reference-adjusted-and-standardized-all-cause-and-crude-probabilities-alternative-net-survival - 2025-08-25

PhD position in Economic History: Neighborhood effects over the life course

Fotograf: Håkan Röjder The PhD position is linked to the research project The long reach of the neighborhood: Health, education and earnings in Landskrona, Sweden, 1904-2015, funded by Handelsbankens forskningsstiftelser. The PhD student will work in this project in collaboration with other project members and will be affiliated with the Centre for Economic Demography at LUSEM (CED, www.ed.lu.se).

https://www.lupop.lu.se/article/phd-position-economic-history-neighborhood-effects-over-life-course - 2025-08-25

Reflection on modern methods: planned missing data designs for epidemiological research

Photo: Pixabay / Gerd Altmann This paper describes the multiform, wave-missing and two-method designs, including their benefits, their impact on bias and power, and other factors that must be taken into consideration when implementing them in an epidemiological study design. Read the paper at https://academic.oup.com/ije/article/49/5/1702/5827680

https://www.lupop.lu.se/article/reflection-modern-methods-planned-missing-data-designs-epidemiological-research - 2025-08-25

Program höst/vinter 2020

Pga Covid-19 har en del programpunkter strukits. 7 oktober kl 12:15  Lunchvisning  "Frukt av alla slag" ingen föranmälan krävs, biljett köpes i Butik Botan kostnad 60 kr. 13 oktober kl 15:00 Framtidsveckans Visning" Växtkraft på intåg - Hot eller löfte om framtiden?" bokningsinformation kommer senare 14-18 oktober Framtidsveckans Utställning "Fjärilarna steg upp" 14 oktober kl 11:15 Seniorvisning

https://www.botan.lu.se/artikel/program-hostvinter-2020-1 - 2025-08-25

Visningar höst och vinter 2020

Pga Corona kan vi endast ta 15 personer per visning. Biljetter till visningar köpes i Butik Botan före visningar. Lunchvisningar kl 12:15-13:00, kostnad 60 kr. 7/10 Frukt av alla slag 4/11 Ett besök i regnskogen 2/12 Julens växter och frön Seniorvisningar kl 11:15-12:00, kostnad 40 kr. 14/10 Kryptogamer 11/11 Tillbaka till rötterna 9/12 Julens växter och frön  

https://www.botan.lu.se/artikel/visningar-host-och-vinter-2020 - 2025-08-25

Kompost-Guidad visning

En kompost är som en mångmiljonstad som sjuder av liv och aktivitet! Men hur får man egentligen den att fungera? Kleopatra införde redan på sin tid dödsstraff för utförsel av kompostmaskar.. Följ med botanisten Julia Borg och trädgårdsteknikern Katarina Löthman-Kaliff på en tur i Botaniska trädgården och få kunskap och inspiration till din egen mångmiljonstad! 3 november kl 12:15-13:00 Är du över

https://www.botan.lu.se/artikel/kompost-guidad-visning - 2025-08-25

Lund Stem Cell Center Releases ATMP Pipeline Report

Photo: Panorama Images from Getty Images Lund Stem Cell Center at Lund University has launched its ATMP Pipeline Report, which maps the pipeline of cell and gene therapies being developed at the center. Advanced Therapy Medicinal Products (ATMPs) are revolutionary medicines based on cells, tissues, or genes, offering new possibilities for treating a wide range of diseases and conditions. In a stra

https://www.stemcellcenter.lu.se/article/lund-stem-cell-center-releases-atmp-pipeline-report - 2025-08-25

A new bioinfomatics pipeline solves a 50-year-old blood group puzzle

Using a data-driven, bioinformatics approach, Lund University researchers have made it possible to take a holistic approach to how our blood group genes are regulated. Photo: iStock/choja Currently, a lot is known about which genes are responsible for our individual blood groups, however not much is understood about how and why the levels of the blood group molecules differ between one person and

https://www.stemcellcenter.lu.se/article/new-bioinfomatics-pipeline-solves-50-year-old-blood-group-puzzle - 2025-08-25