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BACKGROUND: To elucidate the mechanism by which local delivery of 3-morpholino-sydnonimine (SIN-1) affects intimal hyperplasia after percutaneous transluminal coronary angioplasty (PTCA). METHODS: Porcine coronary arteries were treated with PTCA and immediately afterwards locally treated for 5 minutes, with a selective cytosolic guanylate cyclase inhibitor, 1 H-(1,2,4)oxadiazole(4,3-alpha)quinox

Background: Although transposition of the great arteries (TGA) accounts for less than 5% of congenital heart disease, the clinical course is often dramatic with need for early diagnosis and careful preoperative care as well as advanced surgical correction and postoperative support. Since 1993, Lund is one of the two tertiary referral centers for pediatric cardiac surgery in Sweden, with nearly 400

Drug therapy is often directed to specific organ and tissue compartments where the mode of action of the compound effects specifically targeted biological processes. However, the direct measurement of drug uptake in terms of a time kinetic and concentrations attained at the local sites has not been readily available as a clinical index for most drugs. A proof-of-principle study was conducted to te

BACKGROUND: Healthcare today is a complex system with increasing needs of specific knowledge of evaluation of research and implementation into clinical practice. A critical issue is that we all apply evidence-based practice (EBP) with standardised methods and continuing and systematic improvements. EBP includes both scientific and critical assessed experience-based knowledge. For the individual,

The paper describes full-scale fire-fighting tests performed in an underground mine. A total of six different methods to fight a full scale fire in a mine tunnel were tested. The methods involved different fire-fighting equipment but were comparable regarding fundamental conditions such as length of response-route, fire-fighting set-up, and smoke and fire size. The aim was to compare different equ

This study examines how Islamic beliefs affect host-guest interactions from the perspectives of local people in two Islamic heritage villages in Iran. Face-to-face interviews with 51 people across the two settings highlight the significant influence of Islamic beliefs on host-guest interactions and indicate that these beliefs can be supportive of tourism. However, religiosity also significantly in

The exocrine pancreas is mainly regulated via neuro-hormonal pathways. CCK-dependent regulatory pathways and CCK-receptor subtype involved seem to differ between mammalian species. The first aim of the thesis was to establish the physiological dose-range for CCK, to further explore the short entero-pancreatic reflex and CCK-receptor subtypes involved in the CCK-mediated regulation of the exocrin

Varierande likhet i blomdoft – beror det på släktskapsband? De senaste decennierna har kunskapen om blomdoft och dess betydelse i interaktioner mellan växter och insekter ökat avsevärt. Det finns en stor mängd olika doftämnen i blommors doft och blomdoften kan vara högst variabel, inte bara mellan arter utan också mellan individer av samma art. Även om vissa doftämnen verkar sakna ekologisk funktUnderstanding the evolutionary processes behind intraspecific variation and population differentiation is an important topic in biology, since intraspecific variation is required for speciation. Angiosperms show fascinating diversity in flower designs. Since the flower is crucial for reproductive success and at the same time often involved in biotic interactions with pollinators and/or herbivores,

Policy makers and national football associations often emphasize potential benefits of mega-events like the FIFA World Cup or UEFA EURO on tourism (or the economy in general), but empirical studies show no support for this. The effects on tourism, especially of the EUROs, are not well documented in the academic community and it is the purpose of this paper to provide some empirical evidence of the

Cardiovascular diseases are accountable for almost 50 % of the mortality number in Europe which is why research on its causes is highly prioritised. For practical and ethical reasons, in vitro study models are of high importance to enable research on cardiac abnormal behaviours. To meet this issue, researchers from Imec, Belgium, developed Neuray-II, the second generation of a biocompatible chip w

The scramble for Africa’s natural resources has never been more prominent. Rather than contributing to development through means of mineral rents, countries such as Malawi appear to be suffering as result of increased investment from multinational mining corporations. Also known as the resource curse, Malawi’s high natural resource endowment is hurting its citizens, rather than benefitting them. W

Illegal timber harvest and trade is one of the main challenges in the context of global deforestation and sustainability. Different governance and self-governance initiatives throughout the history with the aim to regulate global forest commons have received plenty of criticism. This research investigates the potential of genetic timber tracking technologies as a tool to enhance existing systems a

Agricultural management and vegetation complexity affect arthropod diversity and may alter trophic interactions between predators and their prey. Web-building spiders are abundant generalist predators and important natural enemies of pests. We analyzed how management intensity (tillage, cutting of the vegetation, grazing by cattle, and synthetic and organic inputs) and vegetation complexity (plant

A pollen record obtained from a 2.2-m sediment succession deposited in a small lake in the province of Vasterbotten, north-eastern Sweden, reveals the presence of continuous forest cover since 8,500 calendar years before present (cal B.P.). Forest with abundant Pinus (pine) and Betula (birch) initially colonized the area, followed by a dominance of deciduous trees, primarily Betula, from ca. 8,000

Sveriges transportpolitiska mål belyser vikten av hållbara resor. En nationell cykelstrategi är framtagen som en del i att uppnå det övergripande målet. Cykelplanering måste ske på ett tidigt stadium och vara med under hela planprocessen och bilen måste komma i andra hand i stadsplaneringen. En bra grund i planeringen är att försöka beskriva funktionen i ett differentierat cykelnät, en uppdelning The Swedish transport policy objectives show the importance of sustainable transportation. A national bicycle strategy is developed to help achieve the general objective regarding transportation. The bicycle must be included in the whole process with the car coming in second hand. Basic recommendations for cities are to arrange their bicycle network in at least two parts, a main cycle network and

This thesis explores the problem of domestic violence in Ghana from a socio-legal perspective. It investigates the tensions that arise from the application of customary and state law in order to understand why domestic violence, persist and continues being prevalent in communities in Ghana. It draws on living law theory. Based on a multi-sited research qualitative design, interviews were conducted

Idrottsrörelsen med fotboll i fokus har kommit att förändra sin struktur avsevärt under 1900-talet. Fotbollen har gått från att vara en ideell verksamhet med syfte att samla de lokala invånarna för att utöva sporten till en miljardindustri inom Europa. EU:s konkurrensregler har kommit att spela en viktig roll för att främja idrottens utveckling samt förhindra att marknaden snedvrids genom ekonomisSport movement especially football has change its structure of the sport drastically during the 20th century. Football has transformed from being a non-profit activity with one of its purpose to gather the locals for a friendly game to a multibillion industry within Europe. EU: s competition law has played a crucial part to maintain the development for sport and to prevent distortion of competitio

Self-organization and pattern formation represent the emergence of order in temporal and spatial processes. Self-organization in population ecology is gaining attention due to the recent advances concerning temporal fluctuations in the population size of dispersal-linked subunits. We shall report that spatially structured models of population renewal promote the emergence of a complex power law or