In current times of global change, several sources of stress such as contaminants and high temperatures may act synergistically. The extent to which organisms persist in stressful conditions will depend on the fitness consequences of multiple simultaneously acting stressors and the genetic basis of compensatory genetic responses. Ivermectin is an antiparasitic drug used in livestock that is excret

A growing empirical and theoretical literature has investigated to what extent socioeconomic inequalities are influenced by the outcomes and characteristics of ancestors prior to the parental generation. This study contributes by examining multigenerational associations of adulthood earnings and occupational status in the entire Swedish population of boys and girls born 1968–1976, amounting to alm

Ecological modernisation in the form of support to the notion of green growth remains the dominant discourse in environmental policy globally. Still, questions of limits to economic expansion and growth on a planet with finite natural resources have been at the core of environmental discourses at least since the 1970's. A recent effort by Stoknes and Rockström (2018) seeks to unite notions of ecol

Parkinson's disease is characterized by dopaminergic neuron loss and intracellular inclusions composed mainly of alpha synuclein (α-syn), but the mechanism of pathogenesis is still obscure. In recent years, more attention has been given to the gut as a key player in the initiation and progression of PD pathology. Several studies characterizing changes in the microbiome, particularly the gut microb

Purpose: Since pediatric surgeons aim to follow their patients with anorectal malformations (ARM) into adulthood the aim of this study was to investigate how pediatric surgeons deal with sexual issues related to ARM. Methods: In 2018, a questionnaire was developed by the working group “Follow-up and sexuality” of the ARM-Net consortium and sent to all consortium-linked pediatric surgeons from 31 E

De novo mutations in the gene encoding transcription factor ZMIZ1, located on chromosome 10q22, were recently found to be associated with a novel neurodevelopmental syndrome [1]. In this case report we present a patient with developmental delay and Hirschsprung disease, who carries a de novo mutation in ZMIZ1. Utilizing public gene expression data from mouse we confirm that ZMIZ1 is indeed express

Purpose: The goal of this study was to determine the degree of consensus in the management of spinal cord tethering (TC) in patients with anorectal malformation (ARM) in a large cohort of European pediatric centers. Methods: A survey was sent to pediatric surgeons (one per center) members of the ARM-Net Consortium. Results: Twenty-four (86%) from ten different countries completed the survey. Overa

AIM: Information about healthy children's urinary tract symptoms is scarce but would be helpful in children with congenital urinary tract conditions. The aim of this study was to develop and evaluate a Lower Urinary Tract Dysfunction (LUTD) questionnaire.METHODS: A 15-item questionnaire based on definitions by the International Children's Continence Society (ICCS) about urinary tract function, was

Probabilistic building performance simulations enables a method for evaluating how the data quality used to create input models affects the accuracy of the predicted energy performance. The method described in this paper explores an uncertainty analysis of a fixed building design and system by including the discrepancy between the declared property of a product, material, or behaviour quantified u

South Korea’s past offers an example of an authoritarian context in which police roles proliferated. Besides maintaining order, police officers in Seoul were deployed for all sorts of purposes. Police were positioned as representatives of a state that had, in the 1960s and 1970s, ambitious plans for remaking society. Seoul’s large underclass posed, in the visions of City Hall and the central gover

Quantitative magnetic resonance imaging (qMRI) goes beyond conventional MRI, which aims primarily at local image contrast. It provides specific physical parameters related to the nuclear spin of protons in water, such as relaxation times. These parameters carry information about the local microstructural environment of the protons (such as myelin in the brain). Non- invasive in vivo histology usin

In Asia, the comprehensiveness of political finance systems and the level of implementation vary significantly across countries. This policy paper draws on the 2018 data of the International IDEA Political Finance Database and covers South Asia, South East Asia and East Asia. It investigates three key questions: What are the main corruption risks associated with the funding of political parties an

This dissertation argues that during the latter half of the long nineteenth century, colonial powers around the world co-produced a “global trans-imperial culture” that was facilitated by a common knowledge infrastructure, including international congresses, trans-imperial scholarly exchange and expositions. Japan was an important member of this “colonial club” and was deeply engaged with evolving

Drawing on the IR theories of norm translation and strategic narratives, this article focuses on how states translate international norms to their own advantage by producing strategic narratives to advance their soft power ambitions abroad. Using the example of Feminist Foreign Policy (FFP), the article compares Sweden, Canada, France, and Mexico in their attempts to translate international femini

Several generations of French leaders had high expectations for French Indochina’s usefulness as a symbolic resource for unifying the nation after times of disaster, but in fact the colony time and again proved to be little more than a burden. This chapter explores how a variety of factors, not the least of which was poor planning on the part of the French métropole, dashed the high hopes French l