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The Italian Sarcoma Group and the Scandinavian Sarcoma Group designed a joint study to improve the prognosis for patients with Ewing's family tumors and synchronous metastatic disease limited to the lungs, or the pleura, or a single bone. The study was opened in 1999 and closed to the enrollment in 2008. The program consisted of intensive five-drug combination chemotherapy, surgery and/or radiothe

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Laurdan (6-lauroyl-2-dimethylaminonaphthalene) fluorescence spectroscopy has been applied to probe the physical status of the thylakoid membrane upon conversion of violaxanthin to zeaxanthin. So far, only phospholipid-dominated membranes have been studied by this method and hereby we report the first use of laurdan in mono- and digalactosyldiacylglycerol-dominated membrane systems. The generalised

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A proactive strategy to respond effectively to health impacts related to climate variability, particularly within vulnerable populations, is of vital importance. Such a strategy can be attained if health officials have a deep understanding of how climate variability affects human health and if the resources available for the health care sector are sufficient. This study assessed the perceptions an

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Objective: To explore the natural course of knee osteoarthritis (OA) in a middle-aged population with chronic knee pain. Methods: A population-based sample of 143 subjects (mean age 45 (range 35-54), 44% women) with knee pain (>3 months) at inclusion was studied. Weightbearing posteroanterior tibiofemoral (TF) radiographs were obtained at baseline and 12 years later, and classified according to Ke

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To describe incidence, risk factors, and influence of treatment on occurrence of central nervous system (CNS) relapse or progression in younger patients with aggressive B-cell lymphoma. We analyzed 2210 patients with aggressive B-cell lymphoma treated on various studies for CNS relapse/progression. Treatment consisted of CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) +/- etoposi

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Background and Purpose-Although many stroke patients are young or middle-aged, risk factor profiles in these age groups are poorly understood. Methods-The Stroke in Young Fabry Patients (sifap1) study prospectively recruited a large multinational European cohort of patients with cerebrovascular events aged 18 to 55 years to establish their prevalence of Fabry disease. In a secondary analysis of pa

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Increasing precipitation and surface water temperature due to global change may strengthen the salinity gradient in coastal regions, which could influence the behaviour of dinoflagellate migration. We studied diel vertical migration (DVM) behaviour in the dinoflagellates Prorocentrum minimum and Heterocapsa triquetra using vertically stratified laboratory columns with 3 different salinity gradient

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Purpose - The purpose of this paper is to investigate to what extent male and female PhDs choose academic vs non-academic employment. Further, it analyses gender earnings differences in the academic and non-academic labour markets. Design/methodology/approach - Rich Swedish cross-sectional register data on the stock of PhDs in 2004 is used for investigating differences between male and female PhDs

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The Kalpha satellite spectra arising from the correlative multielectron processes accompanying K-shell photoionization of Ca, Ti and V were measured using a broad range crystal spectrometer. Multiconfiguration Dirac-Fock calculations were performed to interpret the observed,x-ray energies and the spectral line shape., The calculations agree fairly well with the experimental results. The variation

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Trots att kunskaperna om och intresset för smärta och smärtlindring har ökat de senaste åren drabbas fortfarande många patienter en inadekvat smärtlindring och många patienter förväntar sig smärta postoperativt. Syftet med denna studie var att undersöka kvinnor i olika åldrar avseende förväntningar och upplevelser av postoperativ smärta och smärtlindring samt hur stor betydelse den preoperativa in

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This master thesis is commissioned by the company Haldex Brake Products AB based in Landskrona. The company is acting on the road vehicle market. Amongst other products the company produces disc brakes for the heavy road vehicle industry. Disc brakes developed by Haldex, based on the sliding caliper principle, are during certain circumstances experiencing problems with malfunction of the brake due

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Neurogenesis in the adult mammalian brain is well studied, in the two main regions subventricular zone (SVZ) and subgranular zone (SGZ), under different physiological and pathological condition. Recent studies also revealed newly formed neurons in other parts of the brain including the hypothalamus. However, how robust neurogensis in this area is, is still unclear. In this study we used a novel re

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This prospective observational data collection study assessed the cost and quality of life related to hip, vertebral and wrist fracture 1 year after the fracture, based on a patient sample consisting of 635 male and female patients surviving a year after fracture. Data regarding resource use and quality of life related to fractures was collected by questionnaires at baseline, 4 months and 12 month

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The authors performed a retrospective study of 50 patients with endoscopically diagnosed duodenitis who had undergone double-contrast upper gastrointestinal (GI) examinations. Duodenitis was diagnosed on the original radiographic reports in six of 37 patients (16%) with mild-to-moderate duodenitis, five of 13 patients (38%) with severe duodenitis, and 11 of 50 patients (22%) with all grades of duo

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Three commercially available, peptide-based enzyme-linked immunosorbent assay (ELISA) systems (Chlamydia trachomatis IgG and IgA EIA [CT-EIA; Labsystems OY, Helsinki, Finland], SeroCT IgG and IgA [SeroCT; Savyon Diagnostics Ltd., Ashdod, Israel], and Chlamydia trachomatis IgG and IgA pELISA [CT pELISA; Medac, Wedel, Germany]) were evaluated for the detection of serum immunoglobulin G (IgG) and IgA

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A polymorphism consisting of a deletion near the 5' splice site of exon 18 on the alpha2-macroglobulin (A2M) gene (A2M-2) has been suggested to be associated with Alzheimer's disease (AD) in family-based studies. We studied the A2M-2 allele together with the ApoE alleles in a large series on patients with AD (n = 449) and age-matched controls (n = 349). Neuropathologically confirmed diagnoses were