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Learning-related effects and functional neuroimaging

A fundamental problem in the study of learning is that learning-related changes may be confounded by nonspecific time effects. There are several strategies for handling this problem. This problem may be of greater significance in functional magnetic resonance imaging (fMRI) compared to positron emission tomography (PET). Using the general linear model, we describe, compare, and discuss two approac

Lateralized frontal blood flow increases during fluency tasks : influence of cognitive strategy

Difficulties with verbal fluency tasks (VFIT) have been shown mainly to be associated with left frontal lobe pathology in lesion studies. The design fluency test (DFT) is a non-verbal analogue of word fluency tasks and has, in patients with right frontal lobe pathology, been coupled to an inability to perform well. Regional cerebral blood flow measurements (rCBF) were made in normals to elucidate

Roman horticulture beyond the frontier : garden cultivation at Iron Age Uppåkra (Sweden)

Traditionally, the study of Roman cultural imports to Roman Iron Age societies in Scandinavia has been based on analysis of the artefactual record. The starting point has been artefacts held to be high-status objects deriving chiefly from funerary contexts and, to a lesser degree, from settlement sites. Although the existing evidence at Uppåkra, a high-status settlement site in Scania province, Sw

Science and proven experience : a Swedish variety of evidence-based medicine?

A key question for evidence-based medicine (EBM) is how best to model the way in which EBM should “[integrate] individual clinical expertise and the best external evidence” (Sackett et al. 1996). We argue that the formulations and models available in the literature today are modest variations on a common theme and face very similar problems. For example, both the early and updated models of evidenA key question for evidence-based medicine (EBM) is how best to model the way in which EBM should “[integrate] individual clinical expertise and the best external evidence” (Sackett et al. 1996). We argue that the formulations and models available in the literature today are modest variations on a common theme and face very similar problems. For example, both the early and updated models of eviden

Architecture of the human mitochondrial iron-sulfur cluster assembly machinery

Fe-S clusters, essential cofactors needed for the activity of many different enzymes, are assembled by conserved protein machineries inside bacteria and mitochondria. As the architecture of the human machinery remains undefined, we co-expressed in Escherichia coli the following four proteins involved in the initial step of Fe-S cluster synthesis: FXN42-210 (iron donor); [NFS1]·[ISD11] (sulfur dono

Large-scale climatic drivers of regional winter bird population trends

Aim: Changes in climate and land use practices have been found to affect animal populations in different parts of the world. These studies have typically been conducted during the breeding season, whereas the non-breeding season (hereafter ‘winter’) has received much less attention. Changes in regional winter abundances could be caused by changes in overall population sizes and/or redistribution o

Targeted proteomics for the indirect detection of dexamethasone treatment in bovines

The illegal use of pharmacologically active compounds for growth promotion in food-producing species poses risks for consumer health and animal welfare. Surveillance relies on the quantification of drug residues in animal fluids or tissues, but the efficacy can be negatively affected due to undetectable residual concentrations in biological matrices. Consequently, techniques focusing on the indire

Femoral Strength Prediction using Finite Element Models : Validation of models based on CT and reconstructed DXA images against full-field strain measurements

Osteoporosis is defined as low bone density, and results in a markedly increased risk of skeletal fractures. It has been estimated that about 40% of all women above 50 years old will suffer from an osteoporotic fracture leading to hospitalization. Current osteoporosis diagnostics is largely based on statistical tools, using epidemiological parameters and bone mineral density (BMD) measured with du

Deciphering the structure of the West Greenland marine food web using stable isotopes (δ13C, δ15N)

The Arctic is facing major environmental changes impacting marine biodiversity and ecosystem functioning. One way of assessing the responses of an ecosystem to these changes is to quantitatively study food web dynamics. Here, we used stable isotope (δ15N and δ13C) analyses of 39 Arctic marine species to investigate trophic relationships and isotopic niches of the West Greenland food web in 2000–20

Trimethylboron as single-source precursor for boron-carbon thin film synthesis by plasma chemical vapor deposition

Boron-carbon (BxC) thin films are potential neutron converting layers for 10B-based neutron detectors. However, as common material choices for such detectors do not tolerate temperatures above 500 °C, a low temperature deposition route is required. Here, we study trimethylboron B(CH3)3 (TMB) as a single-source precursor for the deposition of BxC thin films by plasma CVD using Ar plasma. The effect

Incidence of oral thrush in patients with COPD prescribed inhaled corticosteroids : Effect of drug, dose, and device

Background and aims Little information is available on real-life occurrence of oral thrush in COPD patients treated with ICS. We investigated oral thrush incidence in COPD patients prescribed FDC ICS/LABA therapies and assessed whether it is modulated by the ICS type, dose, and delivery device. Methods We conducted a historical, observational, matched cohort study (one baseline year before and one

Governance of higher education – implementation of project governance

This article focuses on coordination between governance actors in higher education. The object of the study is a department at a public university, seen as a multi-project environment. The purpose of this article is to illustrate and analyze project governance as a tool that allows departmental management to coordinate with the authorities, the board and the management at different levels at the u

Utformning av murverkskonstruktioner enligt Eurokod 6

Handboken har utarbetats som hjälp för intressenter i byggbranschen att tillämpa Eurokodsystemet på murade konstruktioner. Handboken avses bli ett stöd för projektörer och byggare som varit vana vid att använda nationella svenska byggregler, som BKR, i samband med projekt som uppförs i Sverige. Men handboken kan också vara till nytta för bedömning från beställar- och myndighetssidan av projekt som

Early ontogeny of the Furongian (Cambrian) olenid trilobites Sphaerophthalmus alatus (Boeck, 1838) and Ctenopyge (Mesoctenopyge) tumida Westergård, 1922 from Bornholm, Denmark

The early stages in ontogenetic development are described in the co-occurring Sphaerophthalmus alatus (Boeck, 1838) and Ctenopyge (Mesoctenopyge) tumida Westergård, 1922, using fragmentary but otherwise well-preserved material from Bornholm, Denmark. The former species is a senior synonym of Ctenopyge (Eoctenopyge) angusta Westergård, 1922, as has been recently proposed, but the early stages of S.

Quantitative mass spectrometry to study inflammatory cartilage degradation and resulting interactions with the complement system

Joint diseases are often characterized by inflammatory processes that result in pathological changes in joint tissues, including cartilage degradation and release of components into the synovial fluid. The complement system plays a central role in promoting the inflammation. Because several cartilage proteins are known to interact with complement, causing either activation or inhibition of the sys

FACIN, a double-edged sword of the emerging periodontal pathogen filifactor alocis : A metabolic enzyme moonlighting as a complement inhibitor

Periodontal disease is one of the most common inflammatory infectious diseases worldwide and it is associated with other syndromes, such as cardiovascular disease or rheumatoid arthritis. Recent advances in sequencing allowed for identification of novel periodontopathogens such as Gram-positive Filifactor alocis, but its virulence mechanisms remain largely unknown.We confirmed that F. alocis is a

Subliminal influence on generosity

We experimentally subliminally prime subjects prior to charity donation decisions by showing words that have connotations of pro-social values for a very brief time (17 ms). Our main finding is that, compared to a baseline condition, the pro-social prime increases donations by approximately 10–17 % among subjects with strong pro-social preferences (universalism values). We find a similar effect wh