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Background: OSA is a common sleep-breathing disorder linked to increased risk of cardiovascular disease. Intermittent upper airway obstruction and hypoxia, hallmarks of OSA, have been shown in animal models to induce substantial changes to the gut microbiota composition, and subsequent transplantation of fecal matter to other animals induced changes in BP and glucose metabolism. Research Question:

Context. To take full advantage of upcoming large-scale spectroscopic surveys, it will be necessary to parameterize millions of stellar spectra in an efficient way. Machine learning methods, especially convolutional neural networks (CNNs), will be among the main tools geared at achieving this task. Aims. We aim to prepare the groundwork for machine learning techniques for the next generation of sp

Context. Reconstructing how all the stellar components of the Galaxy formed and assembled over time by studying the properties of the stars that form it is the aim of Galactic archaeology. Thanks to the launch of the ESA Gaia astrometric mission and the development of many spectroscopic surveys in recent years, we are for the first time in the position to delve into the layers of the past of the G

The high-prevalence blood group antigen, Sda, had been puzzling blood bankers and transfusionists for at least a decade when it was reported in 1967. The characteristic mix of agglutinates and free red blood cells (RBCs), caused by anti-Sda, is seen with the RBCs from 90 percent of individuals of European descent. However, only 2-4 percent of individuals are truly Sd(a-) and may produce anti-Sda.

The management of breast cancer during pregnancy (PrBC) is a relatively rare indication and an area where no or little evidence is available since randomized controlled trials cannot be conducted. In general, advances related to breast cancer (BC) treatment outside pregnancy cannot always be translated to PrBC, because both the interests of the mother and of the unborn should be considered. Eviden

This article is concerned with the psychological dimensions of deglobalization and white supremacy as related to fantasies of “whiteness.” The (re)construction of narratives and myths are contested processes, concerning both the struggle for control over historical and cultural space as well as the articulation of particular needs for individuals and groups in the present. We explore the stories a

Objective(s): Nitrite, a nitric oxide (NO) donor, increases insulin secretion from pancreatic islets and has positive metabolic effects in type 2 diabetes (T2D). Here, we test the hypothesis of whether nitrite-induced insulin secretion is due to blunting of diabetes-induced oxidative stress in the islets. Materials and Methods: T2D was created in male rats using a combination of streptozotocin at

Using Marcus theory, the electric-field-dependent charge-separation dynamics of non-fullerene acceptors D/A heterojunctions are simulated. On the D/A interface, the excited-state characteristics show obvious differences under different electric field intensities, providing microscopic details of the non-fullerene D/A interface at the atomic level. For different electric field conditions, so the ca

This chapter focuses on the experiences of powerlessness among police detectives in a global world. Specifically, it discusses how Danish detectives often feel that certain foreign national criminals get away with their crimes with impunity – here not necessarily meaning that criminals are not caught and sentenced. Rather, what increasingly frustrates Danish detectives are their experiences of how

Objectives: The Nasal Obstruction Symptom Evaluation (NOSE) scale is a symptom-specific quality-of-life questionnaire for patients suffering from nasal obstruction. The instrument is designed specifically for patients with septal deviation and for the evaluation of the outcome of septoplasty. The aim of this study was to validate a Swedish version of the NOSE instrument for use in clinical practic

Aims: Iron deficiency (ID) is comorbid in up to 50% patients with heart failure (HF) and exacerbates disease burden. Ferric carboxymaltose (FCM) reduced HF hospitalizations and improved quality of life when used to treat ID at discharge in patients hospitalized for acute HF with left ventricular ejection fraction <50% in the AFFIRM-AHF trial. We quantified the effect of FCM on burden of disease an

We use data from the 17th data release of the Apache Point Observatory Galactic Evolution Experiment (APOGEE 2) to contrast the chemical composition of the recently discovered Gaia Enceladus/Sausage system (GE/S) to those of 10 Milky Way (MW) dwarf satellite galaxies: LMC, SMC, Boötes I, Carina, Draco, Fornax, Sagittarius, Sculptor, Sextans, and Ursa Minor. Our main focus is on the distributions o

This study provides information about the concentration of Tungsten (W), Hafnium (Hf) and Tantal (Ta) in the ESS soil and recommendations on the most appropriate sample preparation and measurement technique to assess contamination by these elements. The current levels of W, Hf and Ta measured in this study are in agreement with the estimated values from previous geological surveys. ICP MS showed l

The recommendation is based on the co-authors’ work organized by the RILEM TC 256-SPF “Spalling of concrete due to fire: testing and modelling”. It aims to provide useful information, guidance and best practices in fire spalling assessment to laboratories that perform large-scale tests based on fire resistance test standards. It provides guidance on the spalling observation techniques during testi

Post-flashover fires inherently lead to external fire plumes, constituting a hazard for rapid fire spread over façades. As multi-storey mass timber buildings with internal visible timber surfaces become more common, there are concerns that such buildings would produce larger external plumes and hazards (assuming all other parameters equal). The literature reveals only indications of this, and how

The cosmogenic radionuclides 7Be and 10Be are useful tracers for atmospheric transport studies. Combining 7Be and 10Be measurements with an atmospheric transport model can not only improve our understanding of the radionuclide transport and deposition processes but also provide an evaluation of the transport process in the model. To simulate these aerosol tracers, it is critical to evaluate the in

BACKGROUND: Proteomic profiling could potentially disclose new pathophysiological pathways for cardiovascular diseases (CVD) and improve prediction at the individual level. We therefore aimed to study the plasma protein profile associated with the incidence of different CVDs. METHODS: Plasma levels of 245 proteins suspected to be linked to CVD or metabolism were measured in 4 Swedish prospective p

The effect of parental age on germline mutation rate across generations is not fully understood. While some studies report a positive linear relationship of mutation rate with increasing age, others suggest that mutation rate varies with age but not in a linear fashion. We investigated the effect of parental age on germline mutations by generating replicated mutation accumulation lines in Caenorha

BACKGROUND: Several molecular classification systems for bladder cancer have been proposed, but due to differences on how to define molecular subtypes, controversies and misunderstandings have arisen. OBJECTIVE: To discuss different aspects of the molecular classification of bladder cancer and to point to the consequences of using different conceptual approaches. To question some underlying assump