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The DNAJB6 chaperone inhibits fibril formation of aggregation-prone client peptides through interaction with aggregated and oligomeric forms of the amyloid peptides. Here, we studied the role of its C-terminal domain (CTD) using constructs comprising either the entire CTD or the first two or all four of the CTD β-strands grafted onto a scaffold protein. Each construct was expressed as WT and as a

While there is significant awareness of the importance of addressing water, sanitation and hygiene (WASH) inequalities, measurement continues to present a challenge. Addressing how inequalities are measured, tracked and communicated is fundamental to accelerating progress in ensuring universal WASH coverage and associated benefits. We review how WASH inequalities have been measured and monitored t

Some two decades ago, Dörnyei (2005) proposed that motivation for L2 learning could be modelled as a self-system. Despite the profound influence of Dörnyei's scholarship and impact of the L2 Motivational Self System (L2MSS) model, the fundamental premise that motivation for L2 learning can constitute a self-system has escaped critical scrutiny. Highlighting how the self-system constitutes a framew

Background: The use of remote services such as video consultations (VCs) has increased significantly in the wake of the COVID-19 pandemic. In Sweden, private healthcare providers offering VCs have grown substantially since 2016 and have been controversial. Few studies have focused on physicians’ experiences providing care in this context. Our aim was to study physicians’ experiences of VCs, focusi

This book explores the relationship between tourism and high-magnitude storm events, including cyclones, hurricanes and typhoons and flooding, across all stages of a disaster. It considers the measures available to manage tourism after major storms and floods, examines the means to mitigate the potential impacts of these disasters on tourism, and provides insights into the ethical and socioeconomi

Phenotypic plasticity is produced and maintained by processes regulating the transcriptome. While differential gene expression is among the most important of these processes, relatively little is known about other sources of transcriptional variation. Previous work suggests that alternative splicing plays an extensive and functionally unique role in transcriptional plasticity, though plastically s

One of the hallmarks of type 1 but also type 2 diabetes is pancreatic islet inflammation, associated with altered pancreatic islet function and structure, if unresolved. IL-1β is a proinflammatory cytokine which detrimentally affects β-cell function. In the course of diabetes, complement components, including the central complement protein C3, are deregulated. Previously, we reported high C3 expre

Purpose: To monitor cardiovascular health, in 2022, the American Heart Association (AHA) updated the construct “Life’s Simple 7” (LS7) to “Life’s Essential 8” (LE8). This study aims to analyze the associations and capacity of discrimination of LE8 and LS7 in relation to self-rated health (SRH) and health-related quality of life (HRQoL). Methods: This study from the Swedish CArdioPulmonary bioImage

Context: The capacity of a landscape to maintain multifunctionality through ongoing pressures relates to its sustainability and is affected by land use policy and environmental changes. In coastal zones, limited empirical evidence exists regarding the impact of macro-level policy changes on local landscapes and their resulting temporal and spatial responses. Objectives: This paper investigates the

Leadership is complex, and leadership in a global business is no less complex. To a great extent, the challenge in leadership is to look at what requirements the specific management task poses, and what opportunities it creates, and to be aware of what expectations and ideas are present, for example in the form of cultural values within a given organization. Greater complexity and variation in app

The most effective way to avoid intense inter- and intra-specific competition at the dung source, and to increase the distance to the other competitors, is to follow a single straight bearing. While ball-rolling dung beetles manage to roll their dung balls along nearly perfect straight paths when traversing flat terrain, the paths that they take when traversing more complex (natural) terrain are n

Mathematical models of cancer and bacterial evolution have generally stemmed from a gene-centric framework, assuming clonal evolution via acquisition of resistance-conferring mutations and selection of their corresponding subpopulations. More recently, the role of phenotypic plasticity has been recognized and models accounting for phenotypic switching between discrete cell states (e.g., epithelial

Context. The star cluster initial mass function is observed to have an inverse power law exponent around 2, yet there is no consensus on what determines this distribution, and why some variation is observed in different galaxies. Furthermore, the cluster formation efficiency (CFE) covers a range of values, particularly when considering different environments. These clusters are often used to empir

Current hemophilia B treatment guidelines recommend routine prophylaxis with factor IX (FIX) replacement products, tailored to maintain plasma activity at levels that will prevent bleeds. However, plasma FIX activity may not be the primary determinant or best indicator of hemostatic efficacy due to its extravascular distribution. FIX replacement therapy has evolved to include extended half-life (E

AimTo explore perceptions of annual surveillance with magnetic resonance imaging and perceptions of care during the examination among women with a hereditary risk of breast cancer.DesignPhenomenography.MethodsFourteen face-to-face interviews using a semi-structured interview guide were conducted among women undergoing surveillance in the southern region of Sweden. A seven-step phenomenographic ana

Astrobiocentrism is a vision that places us in a scenario of confirmation of life in the universe, either as a second genesis or as an expansion of humanity in space. It manages to raise consistent arguments in relation to questions such as what would happen to knowledge if life were confirmed in the universe, how would this change the way we understand our place in the cosmos? Astrobiocentrism ra

Despite improvements in treatment of mantle cell lymphoma (MCL), most patients eventually relapse. In this multicenter phase 1b/2 trial, we evaluated safety and efficacy of minimal residual disease (MRD)-driven venetoclax, lenalidomide, and rituximab (venetoclax-R2) in relapsed/refractory (R/R) MCL and explored the feasibility of stopping treatment in molecular remission. The primary end point was

Type Ia Supernovae (SNe Ia) are considered the most reliable standard candles and they have played an invaluable role in cosmology since the discovery of the Universe's accelerated expansion. During the last decades, the SNe Ia samples have been improved in number, redshift coverage, calibration methodology, and systematics treatment. These efforts led to the most recent “Pantheon” (2018) and “Pan