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We report the presence of platelet-activating factor (PAF-acether; l-0-alkyl-2-acetyl-.v«-glycero-3-phosphocholine) in small-intestinal and colonic mucosa of neonatal rats. The PAF-acether content was higher in the colon than in the small intestine, and was lower in the small intestine of 30-day-old animals than in 14-day-old animals. We also report that cultured intestinal epithelial cells (INT 4

C. A. de Wit and B. R. Weström. Purification and characterization of α2-, α2-β- and β-macroglobulin inhibitors in the hedgehog, Erinaceus europaeus: β-macroglobulin identified as the plasma antihemorrhagic factor. Toxicon 25, 1209 - 1219, 1987. - Three macroglobulin inhibitors were purified from hedgehog (Erinaceus europaeus) plasma by sequential chromatography on Cibacron Blue Sepharose, Sephacry

High concentrations of insulin (411 ± 214 μU/ml), neurotensin-like (265 ± 72 pg/ml), and bom-besin-like immunoreactivities (1995 ± 288 pg/ml) were detected in porcine colostrum using radioimmunoassay, as compared to the levels found in sow blood serum at farrowing (5 μU/ml, <12 pg/ml, and 17 pg/ml, respectively). After 72 h of lactation, the levels of insulin and neurotensin-like immunoreactivitie

We have studied the development of phospholipase A2 (PLA2) and lysophosphatidylcholine (lysoPC)-metabolising enzyme activities in the neonatal rat intestine and its relation to the intestinal permeability of macromolecules. The permeability was determined by feeding young rats a mixture of bovine serum albumin, bovine immunoglobulin G and fluorescein-isothiocyanate-conjugated dextran 70,000, and a

Die Charakterisierung der im Schweineserum vorhandenen Inhibitorfraktionen fur Trypsin, Chymotrypsin und Elastase wurde durch Gelfiltration über Ultrogel AcA44 und Aga-rosegelelektrophorese mit anschließender Demonstration der Hemmaktivität der getrennten Fraktionen durchgeführt. Die Inhibitorfraktionen aus der Gelfiltration wurden weiterhin mittels Antikörper identifiziert, die gegen die Protease

We studied the neural and hormonal regulation of the secretion of pancreatic spasmolytic polypeptide (PSP), a potential growth factor, from isolated perfused porcine pancreas and the pancreatic exocrine secretion of PSP in response to a meal in young conscious pigs. PSP concentrations in the pancreatic juice ranged from 1 to 180 μg/ml. PSP released to the venous effluent amounted to 0.4-7% of the

Hybrid analog-digital beamforming stands out as a key enabler for future communication systems with a massive number of antennas. In this paper, we investigate the hybrid precoder design problem for angle-of-departure (AoD) estimation, where we take into account the practical constraint on the limited resolution of phase shifters. Our goal is to design a radio-frequency (RF) precoder and a base-ba

Gen Z’s interest in ethical consumption, including tourism, is growing in response to pressing global challenges. However, there is limited research on the constraints tied to the ethical travel decisions of this young cohort of travelers. This qualitative study, grounded in the theory of constraints and ethical consumerism literature, addresses this gap. The findings reveal multi-layered and inte

Background: Hypertensive disorders of pregnancy are a leading cause of maternal and perinatal morbidity and mortality. If women at high risk for developing complications could be identified early, level of care could be triaged, limited resources could be correctly allocated and targeted interventions to prevent complications could be implemented. Methods: We updated a systematic review and meta-a

Background and Objectives Structural brain MRI and blood-based phosphorylated tau (p-tau) measures are among the least invasive and least expensive Alzheimer's disease (AD) biomarkers to date. The extent to which these biomarkersmay outperformone another in predicting future Alzheimer dementia diagnosis is poorly understood, however. This study investigated 2 specific AD biomarkers, i.e., a cortic

Vapor–solid–solid (VSS) growth of III-V semiconductor nanowires (NWs) has long been considered an alternative for the vapor–liquid–solid (VLS) growth mode, with the potential to avoid the incorporation of deep-level impurities into semiconductors and to form compositionally abrupt interfaces. Most research however indicates that VSS growth has a much lower growth rate than observed in the VLS grow

In the rapidly advancing domain of autonomous vehicle technology, the management of intersection traffic emerges as a demanding challenge. This paper describes the development and implementation of a novel testbed designed for the investigation of an autonomous intersection management system (AIMS). The research primarily focuses on the complex coordination required among autonomous vehicles for e

This report presents an overview of a set of data collection methods that can be used for the study of wildfire evacuation during community drills. A demonstration of a set of suitable data collection methods is performed during an evacuation drill conducted at Roxborough Park, Colorado (USA) in June 2024. Data collection methods reviewed and adopted included both quantitative and qualitative meth

Background: Circulating dietary biomarkers are not direct proxies for intake, as the biomarkers reflect not only food and supplement consumption but also nutrient absorption, metabolism, and tissue distribution. Therefore, along with nutrient intake, several other upstream factors can impact dietary biomarker concentrations, including demographic, medical history, and genetic factors. Objectives:

This chapter lays the theoretical foundations of long-run economic growth. After providing an overview of the three fundamental regimes that have characterized the process of development over the course of human history on the basis of the seminal work of Galor and Weil (Am Econ Rev 90:806-828, 2000), we review existing theories offering explanations of the different stages of development. In part

Frequent updates in IoT software are crucial for fixing security vulnerabilities, correcting bugs, and adding new features. However, for systems comprising geographically distributed devices, implementing updates is challenging. Such updates must be coordinated across multiple devices, automated without end-user involvement, adaptable to weak connectivity, and minimally disruptive to end users. In

Stratification of cancer into biologically and molecularly similar subgroups is a cornerstone of precision medicine. The Lund Taxonomy classification system for urothelial carcinoma aims to be applicable across the whole disease spectrum including both non–muscle-invasive and invasive bladder cancer. A successful classification system is one that can be robustly and reproducibly applied to new sam

Early metastatic spread and clonal expansion of individual mutations result in a heterogeneous tumour landscape in metastatic urothelial cancer (mUC). Substantial molecular heterogeneity of common drug targets, such as membranous NECTIN4, FGFR3 mutations, PDL1 or immune phenotypes, has been documented between primary and metastatic tumours. However, translational and clinical studies frequently do