Diffusion MRI uses the random displacement of water molecules to sensitize the signal to brain microstructure and to properties such as the density and shape of cells. Microstructure modeling techniques aim to estimate these properties from acquired data by separating the signal between virtual tissue 'compartments' such as the intra-neurite and the extra-cellular space. A key challenge is that th

The COVID-19 pandemic amplified demands on parents regarding balancing childcare and working from home. How parents distribute responsibilities differs culturally, and governments undertook varied strategies to address COVID-19. Research indicates that the pandemic resulted in increased burden for mothers, but also that it created a novel situation in which parenting and working styles could be re

Objective – In response to unrelenting disruptions in academic publishing and higher education ecosystems, the Informed Systems approach supports evidence based professional activities to make decisions and take actions. This conceptual paper presents two core models, Informed Systems Leadership Model and Collaborative Evidence-Based Information Process Model, whereby co-workers learn to make info

The paper presents digital nomads’ experiences about the support of digital technologies in relation to social isolation. Despite the abundant access to digital technologies for organizational cooperative purposes, the challenge of social isolation constitutes one of the central concerns in nomadicity practices, affecting employees’ choice of working arrangements. To gain further knowledge on the

Contemporary organizations frequently employ projects to leverage work across organizational units, utilizing specialized knowledge from different areas of the organization to meet specific quality criteria in a defined time period, at a set cost. Project managers act as hubs of knowledge in directing projects and driving their success, often using technology for this purpose. To date, little is k

The paper explores the perceptions of university students and their desired features on the use of blockchain technology for the management of education records. A literature review forms the theoretical basis of the research allowing to explore how education records are managed nowadays and the potential for the use of blockchain technology in this area. The theoretical framework is then used to

The paper examines the perceptions of knowledge workers of small-medium enterprises (SMEs) in the Chinese context in regards to managing innovation in their knowledge work with the support of digital technologies. Main concepts such as knowledge, knowledge work, knowledge workers, innovation in knowledge work and digital technologies along with Socialization, Externalization, Combination and Inter

This interpretive focused-ethnographic study was conducted to illuminate and gain deeper understanding on managers’ everyday cooperative work practices using artefacts. In the dissertation, artefacts refer to digital technologies and information. The doctoral research specifically examines how artefacts in the workplace of an academic library are used in academic library managers’ everyday coopera

As has been argued by systems thinking scholars, science and scientific thinking can be seen as socially constructed systems of institutionalized sets of activities through which systems thinking emerged. In this paper, the development of systems approaches is discussed to argue for the research approach adopted. Further, main concepts of systems thinking such as complexity, worldview, and human a

Recognizing that information has long been an important asset for any organization, I explore in depth the management and use of information in contemporary information-intensive organizations such as academic libraries. Information processes, when integrated in the academic library’s daily working life can lead to workplace learning, with long term benefits. However, the literature demonstrates t

In this paper, I briefly present my doctoral thesis research proposal. Recognizing that information has long been an important asset for any organization, I wish to explore in depth the management and use of information in contemporary information-intensive organizations such as academic libraries. Additionally, this research proposal emerges out of recognition that the academic library is a dynam

In this literature review, the author examines the scholarly literature of Information Management (IM) and related fields in the recognition that information has long been an important asset for any organization. However, nowadays the work environment in organizations is more complicated due to the information overload that employees experience on a daily basis. The information deluge requires emp

The paper presents ethical and legal challenges of holographic communication technologies and suggests a framework to address them. Holographic communications enable the capturing of a user’s 3D depiction via special equipment, and its high-quality transmission to another user located elsewhere, introducing a distinctive data communication experience. Their wrongful use could compromise basic huma

Apolipoprotein E4 (ApoE4) is the most important genetic risk factor for Alzheimer's disease (AD). Among the earliest changes in AD is endosomal enlargement in neurons, which was reported as enhanced in ApoE4 carriers. ApoE is thought to be internalized into endosomes of neurons, whereas β-amyloid (Aβ) accumulates within neuronal endosomes early in AD. However, it remains unknown whether ApoE and A

BACKGROUND: Amyloid-β (Aβ) is a normal product of neuronal activity, including that of the aggregation-prone Aβ42 variant that is thought to cause Alzheimer's disease (AD). Much knowledge about AD comes from studies of transgenic rodents expressing mutated human amyloid-β protein precursor (AβPP) to increase Aβ production or the Aβ42/40 ratio. Yet, little is known about the normal expression of Aβ

OBJECTIVE: Salt-inducible kinase 2 (SIK2) is abundantly expressed in adipocytes and downregulated in adipose tissue from individuals with obesity or insulin resistance. The main aims of this work were to investigate the involvement of SIKs in the regulation of glucose uptake in primary mature human adipocytes and to identify mechanisms underlying this regulation.METHODS: Primary mature adipocytes