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Rearrangements of chromosome arm 15q are rare but recurrent in conventional lipomas, a tumor type often showing deregulated expression of the HMGA2 gene. In order to assess whether 15q rearrangements could constitute a distinct pathogenetic mechanism, we studied seven cases of conventional lipoma that at G-banding analysis had various rearrangements of 15q12-q21. The breakpoints in 15q were mapped
Using a multitissue, genome-wide gene expression approach, we recently identified a gene module linked to the extent of human atherosclerosis. This atherosclerosis module was enriched with inherited risk for coronary and carotid artery disease (CAD) and overlapped with genes in the transendothelial migration of leukocyte (TEML) pathway. Among the atherosclerosis module genes, the transcription cof
This article examines the cultural and social dynamics of a multi-ethnic medieval town. Taking the lower town of Tallinn as a case study, this paper identifies the major urban ethnic groups living in the town and discusses their co-existence, self-definition, and processes of categorization. It explores ambiguities arising from daily interactions in the shared physical landscape of the town, such
ObjectiveTo study the impact of swollen to tender joint count ratio (STR) and other baseline characteristics on treatment response to a first course of anti-tumor necrosis factor (anti-TNF) therapy in rheumatoid arthritis (RA) patients. MethodsPatients with RA initiating their first course of anti-TNF treatment were included in a structured clinical followup protocol. Based on pragmatic thresholds
The purpose was to illuminate parents' experiences when their children are undergoing an elective colonoscopy performed using polyethylene glycol-based regimes for bowel preparation.
Epigenetic dysregulation has been associated with cognitive decline and Alzheimer's disease. The present study investigated associations between common SNPs in genes regulating DNA methylation and age-related changes in cognitive decline in two independent prospective cohorts of patients suffering from mild cognitive impairment. An association between the rs1187120 SNP in DNMT3A and annual decline
Protecting semi-natural grasslands may through spill-over benefit species richness and abundance of flower-visiting insects in linear habitats, such as uncultivated field boundaries, in agricultural landscapes. However, whether local diversity increases both with decreasing distance from potential source habitats and increasing landscape heterogeneity is poorly known due to a general lack of studi
Extraction and analysis of labile compounds in complex sample matrices, such as plants, is often a big analytical challenge. In this work, the use of a "green and clean" pressurised hot water extraction (PHWE) approach performed in continuous flow mode is explored. Experimental data for extraction and degradation kinetics of selected compounds were utilised to develop a continuous flow extraction
A brief analysis of the American poster to the Swedish vampire film Let the Right One In, relating to genre, audiences and distribution.
Objective. The aim of this study was to investigate how distance to hospital and socioeconomic status (SES) influence the use of secondary health care (SHC) when taking comorbidity into account. Design and setting. A register-based study in Ostergotland County. Subjects. The adult population of Ostergotland County. Main outcome measures. Odds of SHC use in the population and rates of SHC use by pa
The use of compression garments in treating lymphedema following treatment of genital (penis, testes, uterus, cervical) and breast cancer treatment is a well-established practice. Although compression garments are classified in compression classes, little is known about the actual subgarment pressure exerted along the extremity. The aims of this study were to establish an in vitro method for measu
This paper provides a general framework for electromagnetic (EM) modeling, sensitivity analysis, computation, and measurements regarding the wave propagation characteristics of high-voltage direct-current (HVDC) power cables. The modeling is motivated by the potential use with transient analysis, partial-discharge measurements, fault localization and monitoring, and is focused on very long (10 km
This paper reports a new Early Cretaceous flora discovered recently near the village of Estercuel (Teruel province, northeastern Spain). The plant bearing beds belong to the uppermost part of the Early Cretaceous succession, at the top of the fluvial deposits of the Utrillas Formation. The site has yielded a diverse assemblage of plant compressions including lycopods and ferns, various gymnosperms
Singlet fission is the spin-allowed conversion of a spin-singlet exciton into a pair of spin-triplet excitons residing on neighbouring molecules. To rationalize this phenomenon, a multiexcitonic spin-zero triplet-pair state has been hypothesized as an intermediate in singlet fission. However, the nature of the intermediate states and the underlying mechanism of ultrafast fission have not been eluc
In alternate partial root-zone irrigation (APRI) a significant amount of irrigation water can be saved without considerable yield reduction. In this paper, Hydrus-2D/3D was used to investigate the impact of geometric design of alternate partial root-zone subsurface drip irrigation (APRSDI) with brackish water for growing tomato on soil moisture and salinity distribution. Three inter-plant emitter
The purpose of this work is to study the deformation of elastic cantilevers due to hydrodynamic forces by coupled fluid-structure interaction simulations. The cantilever is placed in a rectangular duct and the Reynolds number based on bulk velocity and cantilever diameter is 400. Reduced velocities in the range pi/4 to 2 pi are studied, which covers both un-synchronised motion and the initial bran
Rarely does the death of animals cause conflict between governments. However, the killing of some animals, such as seals, wolves, and other exotic wildlife, can cause heated conflict over whether the act of killing is itself justifiable.This paper provides an overview of a recent disagreement along these lines – between the EU and Sweden over the management of wolves. It juxtaposes the recent poli
