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Background: Migration is important for the metastatic capacity and thus for the malignancy of cancer cells. There is limited knowledge on regulatory factors that promote the migration of neuroblastoma cells. This study investigates the hypothesis that protein kinase C (PKC) isoforms regulate neuroblastoma cell motility. Methods: PKC isoforms were downregulated with siRNA or modulated with activato

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This paper concerns mathematical modeling and computational fluid dynamics of back-shocking during hollow fibre ultrafiltration of dextran T500. In this paper we present a mathematical model based on first Principles, i.e., solving the Navier-Stokes equation along with the continuity equation for both the solute and the solvent. We investigate the validity of the estimate On the optimal back-shock

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Background: Dercum's disease is characterised by pronounced pain in the adipose tissue and a number of associated symptoms. The condition is usually accompanied by generalised weight gain. Many of the associated symptoms could also be signs of depression. Depression in Dercum's disease has been reported in case reports but has never been studied using an evidence-based methodology. The aim of this

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Recent years molecular imprinting has received considerable attention as an excellent and simple approach to recognize small molecules and bioactive substances. The aim of this study is to prepare the bilirubin-imprinted supermacroporous cryogels which can be used for the adsorption of bilirubin from human plasma. N-methacryloyl(L)-tyrosinemethylester (MAT) was chosen as the preorganization monome

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Planar ground float glass surfaces and the surfaces within holes are polished using fluid jet polishing (FJP) in order to improve their visual appearance or material strength. The large flexibility of FJP makes it suitable for polishing holes and other complex geometries. The influence of polishing speed, incident angle, distance, pressure, abrasive concentration, and nozzle diameter are investiga

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SUMMARY Because of the strong causal relationship between persistent infections of human papillomavirus (HPV) and cervical intraepithelial neoplasia (CIN) and cancer, HPVtesting has been proposed for improvement of cervical screening programs, including triaging and follow-up after treatment for CIN. We developed two new methods for HPV-testing with genotyping: A high-throughput HPV genotyping met

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Numerous studies have been performed aimed at limiting the extent of retinal injury after ischemia, but there is still no effective pharmacological treatment available. The aim of the present study was to examine the role of tumor necrosis factor (TNF)α and its receptors (TNF-R1 and TNF-R2), especially considering the neuroretina and the retinal vasculature since the retinal blood vessels are key

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Recension av Marie Moutier, Wehrmachtsoldaternas brev från fronten 1939–1945.

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We examined the effects of 50-Hz magnetic fields in the range of flux densities relevant to our current environmental exposures on action potential (AP), after-hyperpolarization potential (AHP) and neuronal excitability in neurons of land snails, Helix aspersa. It was shown that when the neurons were exposed to magnetic field at the various flux densities, marked changes in neuronal excitability,

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Objective To assess the impact of the indication for a previous caesarean section on the outcome of a subsequent delivery. Design Population-based cohort study. Setting Sweden. Population Women with two deliveries between 1987 and 2007 identified using the Swedish Medical Birth Registry. Methods The outcome of 69 133 pregnancies after one caesarean section was compared with the outcome of 487 610

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Prior twin and adoption studies have demonstrated the importance of both genetic and shared environmental factors in the etiology of criminal behavior (CB). However, despite substantial interest in life-course theories of CB, few genetically informative studies have examined CB in a developmental context.

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Background: Pre-hospital electrocardiogram (ECG) transmission to an expert for interpretation and triage reduces time to acute percutaneous coronary intervention (PCI) in patients with ST elevation Myocardial Infarction (STEMI). In order to detect all STEMI patients, the ECG should be transmitted in all cases of suspected acute cardiac ischemia. The aim of this study was to examine the ability of

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Objectives To compare two-dimensional (2D) and three-dimensional (3D) transvaginal ultrasound with magnetic resonance imaging (MRI) as the gold standard in assessment of parametrial infiltration of cervical cancer and to determine if all parts of the cervix are equally assessable with ultrasound. Methods Patients with macroscopically evident and histologically confirmed cervical cancer were staged

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The physics of extreme ultraviolet attosecond pulse trains generated during the interaction between an intense laser pulse and a gas medium is presented, including a simple model based on the solution of the classical equations of motion of an electron in an oscillating laser field. The reconstruction of attosecond beating by the interference of a two-photon transition is described and used to det

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The thesis is an attempt to contribute to a critical discussion around the discourses that characterize HIV in southern Africa in general, and in Swaziland in particular. The aim of the study is to explore and visualize the experiences of HIV-positive Swazi Christians in church and society, as well as an attempt to explain these experiences with the contributions of key informants and the Swazi tr

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Ammonia detection is highly relevant for combustion in boilers and furnaces since NH3 is able to suppress nitric oxide levels by catalytic as well as non-catalytic reduction. The mixing of ammonia with flue gases is an important parameter to obtain efficient non-catalytic reduction. In this paper picosecond DIAL was used for range-resolved, single ended, NH3 detection, utilizing a tunable picoseco