AML with mutated NPM1 occurs in all age groups. Yet, the mutational pattern is not extensively studied in the very old, which may hamper appropriate risk assessment. Herein we examined 22 cases of NPM1-mutated de novo AML in patients older than 75, with a median age of 84. All diagnostic samples were sequenced aiming for coverage of the most relevant AML-associated mutations. For comparison with y

New therapeutic agents for haemophilia with inhibitors that are in development or already licensed are expected to provide transformative treatment options. Many of these new therapies are not based on simply replacing the missing factor; new strategies include bispecific antibody technology that mimics factor VIII coagulation function (emicizumab), and inhibition of anticoagulant proteins such as

In Latin-America -as in most parts of the world- indigenous peoples are ‘the poorest of the poor, and the most excluded of the excluded’. Poverty goes hand in hand with their situation of vulnerability, exclusion and disempowerment. How can this situation be changed? How to find adequate frameworks able to facilitate the overturn of their structural disenfranchisement? Departing from the jurisprud

Every of the seven chapters of the course aims at introducing the students to the basics of Romanian language in the larger context of the Romanian culture and civilization development, with the ultimate purpose of settling both a few essential theoretical knowledge and some practical communication skills for the foreign students as inhabitants of Romania. The compulsory tasks at the end of each c

It is composed following the Common European Framework of Reference for Languages (A1-B2 levels, understanding of oral and written texts). It turns to good account the composition exercises of Norwegian, Czech, Swedish and Arab students of the previous ten years teaching experience; it promotes Romanian culture and civilization landmarks; it considers probable day-to-day language understanding sit

The emergence of electric bikes (e-bikes) has brought a paradigm shift in shared mobility with a promise to move towards the mission of sustainable cities. Whereas an in-depth understanding of e-bike riding characteristics iscrucial to effectively design the infrastructure for active mobility, it remains an open area of research. We take the first step towards modelling the e-bike navigation comfo

The ongoing COVID-19 pandemic affects people worldwide. The policies in response to the virus range from closure of national borders to curfews for entire metropolises, like Paris. While we can expect severe impacts on the world economy, the consequences of the pandemic for local sustainability transitions are entirely unclear. In this exploratory study, we investigate how the current situation af

Rapporten är en förstudie avseende potential för biogasproduktion i Helsingborg,baserad på vegetation från urbana gräsytor. Rapporten fokuserar på frågor rörande tekniska aspekter på hela kedjan, dvs. från skörd av stadsgräs till leverans av vegetationen till en biogasanläggning. Rapporten innefattar även stad-landperspektivet, och värdet av biogödseln, samt olika nyttor för urbana gräsytor genom

Artikel i Nationalencyklopedin

Solid oxide fuel cells (SOFCs) produce electricity with high electrical efficiency and fuel flexibility without pollution, for example, CO2, NOx, SOx, and particles. Still, numerous issues hindered the large-scale commercialization of fuel cell at a large scale, such as fuel storage, mechanical failure, catalytic degradation, electrode poisoning from fuel and air, for example, lifetime in relation

Efficient and robust control strategies can greatly contribute to the reliability of fuel cell systems, and a stable output voltage is a key criterion for evaluating a fuel cell system's reliability as a power source. In this study, a polymer electrolyte fuel cell (PEFC) system model is developed, and its performances under different operating conditions are studied. Then two different novel contr

Applying pre-processing and geometric transformation, for the generalization of building blocks, can lead to spatial conflicts which are mainly resolved by displacement. However, the conflicts may not be resolved, due to the insufficient space for displacement or the existence of other objects that prevent displacement. This article proposes a novel model combining building block displacement and

Across the world, children are forced to leave their homes for far-flung destinations. This global phenomenon has particular impact in Europe, where there are now more child refugees than since World War II. Education plays an important role for children with extraordinary experiences seeking to build meaningful lives in their new context. This article offers a new theoretical approach to underpin