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Direct conversion of human somatic cells to induced neurons (iNs), using lineage-specific transcription factors has opened new opportunities for cell therapy in a number of neurological diseases, including epilepsy. In most severe cases of epilepsy, seizures often originate in the hippocampus, where populations of inhibitory interneurons degenerate. Thus, iNs could be of potential use to replace t

The human population displays wide variety in demographic history, ancestry, content of DNA derived from hominins or ancient populations, adaptation, traits, copy number variation, drug response, and more. These polymorphisms are of broad interest to population geneticists, forensics investigators, and medical professionals. Historically, much of that knowledge was gained from population survey pr

The Internet of Things (IoT) paradigm brings an opportunity for advanced Demand Response (DR) solutions. It enables visibility and control on the various appliances that may consume, store or generate energy within a home. It has been shown that a centralized control on the appliances of a set of households leads to efficient DR mechanisms; unfortunately, such solutions raise privacy and scalabili

Schemes to promote sustainable forest management have increasingly focused on addressing widespread informalities in timber production, based on the presumed links between formalisation, the maintenance of forest cover and local welfare. This trend is typified by the EU Forest Law Enforcement, Governance and Trade (FLEGT) initiative and associated Voluntary Partnership Agreements (VPA) aimed at er

We identify, through a change of variables, solution operators for evolution equations with generators given by certain simple first-order differential operators acting on Fock spaces. This analysis applies, through unitary equivalence, to a broad class of supersymmetric quadratic multiplication-differentiation operators acting on L2.Rn/ which includes the elliptic and weakly elliptic quadratic op

Biohythane is a hydrogen-methane blend with hydrogen concentration between 10 and 30% v/v. It can be produced from different organic substrates by two sequential anaerobic stages: a dark fermentation step followed by a second an anaerobic digestion step, for hydrogen and methane production, respectively. The advantages of this blend compared to either hydrogen or methane, as separate biofuels, are

Over the last decades, the Western world has seen millions of relatively well-paid manufacturing jobs disappear. Some have shifted to low-income countries, while other have been permanently lost due the introduction of labor-saving technologies. Concurrently, many comparatively low-wage jobs have been created in services, for example in fast food and retailing. This paper uses a dynamic panel of 2

Drawing on contemporary publications in German and Swedish/Scandinavian journals and biographies as well as conference proceedings of the German Society of Urology (DGU), this paper examines the Swedish impressions of the 1929 DGU meeting in Munich. It focusses on why the Swedish delegates visited the congress and how they evaluated their congress experiences for their Scandinavian peers. Finally,

In 2007 Finland changed ownership rights to inventions from its employees - "the professor's privilege" - to universities. We investigate how this change affected academic patenting using new data on inventors and patenting in Finland for the period 1995-2010. Matched sample panel data regressions using difference-in-differences show that patenting by individuals dropped by at least 29 percent aft

This communication proposes to use the 1-λ resonant mode of slot radiator with single feeding for bandwidth enhancement. The impedance of a simple slot radiator is studied using computer simulation. Since operating the slot radiator in the 1-λ resonant mode requires a longer slot length, a large square slot is used at both ends of the slot to reduce the required slot length. The results of the stu

I rapporten från SNS Konjunkturråd 2018 analyserar och diskuterar tre nationalekonomer kapitalbeskattningens förutsättningar i Sverige. Författarna finner brister i kapitalinkomsternas beskattning och föreslår en enhetligare beskattning. De förespråkar också en löpande fastighetsskatt för både småhus och bostadsrätter men lägre skatt på omsättning av fastigheter. Rapporten pekar också på att en sk

Background: Soft-tissue sarcomas (STSs) are a group of rare, heterogeneous, and aggressive tumors, with high metastatic risk and relatively few efficient systemic therapies. We hypothesized that the Genomic Grade Index (GGI), a 108-gene signature previously developed in early-stage breast cancer, might improve the prognostic assessment of patients with early-stage STS. Patients and methods: We col

Background: Steroid nasal irrigation for chronic rhinosinusitis patients following endoscopic sinus surgery reduces symptom recurrence. There are minimal safety data to recommend this treatment. This study evaluated the safety of betamethasone nasal irrigation by measuring its impact on endogenous cortisol levels. Methods: Participants performed daily betamethasone nasal irrigation for six weeks.

One of the most widely used tools for assessing and communicating scienti c uncertainty is Grading of Recommendations Assessment, Development, and Evaluation (GRADE), a system for rating the quality of evidence and grading strength of recommendations in healthcare. More than 100 organisations around the world—WHO included1— are using GRADE or have endorsed it.In GRADE, a quantitative assessment of